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Secreted protein acidic and rich in cysteine-induced cellular senescence in colorectal cancers in response to irinotecan is mediated by P53.
Chan JM, Ho SH, Tai IT. Chan JM, et al. Among authors: tai it. Carcinogenesis. 2010 May;31(5):812-9. doi: 10.1093/carcin/bgq034. Epub 2010 Feb 17. Carcinogenesis. 2010. PMID: 20164124
Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies.
Tai IT, Dai M, Chen LB. Tai IT, et al. Carcinogenesis. 2005 May;26(5):908-15. doi: 10.1093/carcin/bgi034. Epub 2005 Feb 24. Carcinogenesis. 2005. PMID: 15731169
Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy.
Tai IT, Dai M, Owen DA, Chen LB. Tai IT, et al. J Clin Invest. 2005 Jun;115(6):1492-502. doi: 10.1172/JCI23002. Epub 2005 May 12. J Clin Invest. 2005. PMID: 15902309 Free PMC article.
Synergism between vitamin D and secreted protein acidic and rich in cysteine-induced apoptosis and growth inhibition results in increased susceptibility of therapy-resistant colorectal cancer cells to chemotherapy.
Taghizadeh F, Tang MJ, Tai IT. Taghizadeh F, et al. Among authors: tai it. Mol Cancer Ther. 2007 Jan;6(1):309-17. doi: 10.1158/1535-7163.MCT-06-0517. Mol Cancer Ther. 2007. PMID: 17237289
A novel interaction between procaspase 8 and SPARC enhances apoptosis and potentiates chemotherapy sensitivity in colorectal cancers.
Tang MJ, Tai IT. Tang MJ, et al. Among authors: tai it. J Biol Chem. 2007 Nov 23;282(47):34457-67. doi: 10.1074/jbc.M704459200. Epub 2007 Sep 26. J Biol Chem. 2007. PMID: 17897953
Meta-analysis of colorectal cancer gene expression profiling studies identifies consistently reported candidate biomarkers.
Chan SK, Griffith OL, Tai IT, Jones SJ. Chan SK, et al. Among authors: tai it. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):543-52. doi: 10.1158/1055-9965.EPI-07-2615. Cancer Epidemiol Biomarkers Prev. 2008. PMID: 18349271
SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response.
Cheetham S, Tang MJ, Mesak F, Kennecke H, Owen D, Tai IT. Cheetham S, et al. Among authors: tai it. Br J Cancer. 2008 Jun 3;98(11):1810-9. doi: 10.1038/sj.bjc.6604377. Epub 2008 May 6. Br J Cancer. 2008. PMID: 18458674 Free PMC article.
SPARC in cancer biology: its role in cancer progression and potential for therapy.
Tai IT, Tang MJ. Tai IT, et al. Drug Resist Updat. 2008 Dec;11(6):231-46. doi: 10.1016/j.drup.2008.08.005. Epub 2008 Oct 11. Drug Resist Updat. 2008. PMID: 18849185 Review.
Alternative expression analysis by RNA sequencing.
Griffith M, Griffith OL, Mwenifumbo J, Goya R, Morrissy AS, Morin RD, Corbett R, Tang MJ, Hou YC, Pugh TJ, Robertson G, Chittaranjan S, Ally A, Asano JK, Chan SY, Li HI, McDonald H, Teague K, Zhao Y, Zeng T, Delaney A, Hirst M, Morin GB, Jones SJ, Tai IT, Marra MA. Griffith M, et al. Among authors: tai it. Nat Methods. 2010 Oct;7(10):843-7. doi: 10.1038/nmeth.1503. Epub 2010 Sep 12. Nat Methods. 2010. PMID: 20835245
Absence of MMP2 expression correlates with poor clinical outcomes in rectal cancer, and is distinct from MMP1-related outcomes in colon cancer.
Wong JC, Chan SK, Schaeffer DF, Sagaert X, Lim HJ, Kennecke H, Owen DA, Suh KW, Kim YB, Tai IT. Wong JC, et al. Among authors: tai it. Clin Cancer Res. 2011 Jun 15;17(12):4167-76. doi: 10.1158/1078-0432.CCR-10-1224. Epub 2011 Apr 29. Clin Cancer Res. 2011. PMID: 21531813
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