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Recombinant Modified Vaccinia Virus Ankara Generating Ebola Virus-Like Particles.
Schweneker M, Laimbacher AS, Zimmer G, Wagner S, Schraner EM, Wolferstätter M, Klingenberg M, Dirmeier U, Steigerwald R, Lauterbach H, Hochrein H, Chaplin P, Suter M, Hausmann J. Schweneker M, et al. J Virol. 2017 May 12;91(11):e00343-17. doi: 10.1128/JVI.00343-17. Print 2017 Jun 1. J Virol. 2017. PMID: 28331098 Free PMC article.
We have constructed a modified vaccinia virus Ankara-Bavarian Nordic (MVA-BN) recombinant coexpressing VP40 and GP of EBOV Mayinga and the NP of Tai Forest virus (TAFV) (MVA-BN-EBOV-VLP) to launch noninfectious EBOV VLPs as a second vaccine modality in the MVA-BN-EBOV-VLP- …
We have constructed a modified vaccinia virus Ankara-Bavarian Nordic (MVA-BN) recombinant coexpressing VP40 and GP of EBOV Mayinga and the N …
Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model.
Duehr J, Wohlbold TJ, Oestereich L, Chromikova V, Amanat F, Rajendran M, Gomez-Medina S, Mena I, tenOever BR, García-Sastre A, Basler CF, Munoz-Fontela C, Krammer F. Duehr J, et al. J Virol. 2017 Jul 27;91(16):e00652-17. doi: 10.1128/JVI.00652-17. Print 2017 Aug 15. J Virol. 2017. PMID: 28592526 Free PMC article.
We tested the binding breadth of the resulting monoclonal antibodies using a set of recombinant surface glycoproteins from Reston, Tai Forest, Bundibugyo, Zaire, Sudan, and Marburg viruses and found two antibodies that showed pan-ebolavirus binding. ...
We tested the binding breadth of the resulting monoclonal antibodies using a set of recombinant surface glycoproteins from Reston, Tai
Spontaneous Mutation at Amino Acid 544 of the Ebola Virus Glycoprotein Potentiates Virus Entry and Selection in Tissue Culture.
Ruedas JB, Ladner JT, Ettinger CR, Gummuluru S, Palacios G, Connor JH. Ruedas JB, et al. J Virol. 2017 Jul 12;91(15):e00392-17. doi: 10.1128/JVI.00392-17. Print 2017 Aug 1. J Virol. 2017. PMID: 28539437 Free PMC article.
Intriguingly, T544I is not found in any Sudan, Bundibugyo, or Tai Forest ebolavirus sequences. Furthermore, T544I did not emerge when we serially passaged recombinant VSV encoding GP(1,2) from these ebolaviruses. ...We further show that this mutation may be unique to the s …
Intriguingly, T544I is not found in any Sudan, Bundibugyo, or Tai Forest ebolavirus sequences. Furthermore, T544I did not emerge when …
Bushmeat Hunting and Zoonotic Transmission of Simian T-Lymphotropic Virus 1 in Tropical West and Central Africa.
Mossoun A, Calvignac-Spencer S, Anoh AE, Pauly MS, Driscoll DA, Michel AO, Nazaire LG, Pfister S, Sabwe P, Thiesen U, Vogler BR, Wiersma L, Muyembe-Tamfum JJ, Karhemere S, Akoua-Koffi C, Couacy-Hymann E, Fruth B, Wittig RM, Leendertz FH, Schubert G. Mossoun A, et al. J Virol. 2017 Apr 28;91(10):e02479-16. doi: 10.1128/JVI.02479-16. Print 2017 May 15. J Virol. 2017. PMID: 28298599 Free PMC article.
Using serological and PCR assays, we screened humans and NHPs at two Sub-Saharan African sites where subsistence hunting was expected to be less (Tai region, Cote d'Ivoire [CIV]) or more (Bandundu region, Democratic Republic of the Congo [DRC]) developed. ...
Using serological and PCR assays, we screened humans and NHPs at two Sub-Saharan African sites where subsistence hunting was expected to be …
Development of a duplex semi-nested PCR assay for detection of classical goose parvovirus and novel goose parvovirus-related virus in sick or dead ducks with short beak and dwarfism syndrome.
Li P, Zhang R, Chen J, Sun D, Lan J, Lin S, Song S, Xie Z, Jiang S. Li P, et al. J Virol Methods. 2017 Nov;249:165-169. doi: 10.1016/j.jviromet.2017.09.011. Epub 2017 Sep 14. J Virol Methods. 2017. PMID: 28918072
Using the duplex PCR assay, NGPV was tested positive in all the 15 duck flocks with SBDS, whereas classical GPV was not detected in all the 133 sick and dead ducks collected from East China. A total of 87 (91.58%) Cherry Valley ducks aged from 5 to 18days and 35 (92.11%) m …
Using the duplex PCR assay, NGPV was tested positive in all the 15 duck flocks with SBDS, whereas classical GPV was not detected in all the …