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1975 3
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1977 2
1978 1
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1980 4
1981 5
1982 2
1983 9
1984 8
1985 5
1986 5
1987 6
1988 8
1989 15
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1991 14
1992 17
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1994 26
1995 32
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1997 33
1998 32
1999 50
2000 56
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2002 46
2003 62
2004 53
2005 59
2006 52
2007 72
2008 88
2009 68
2010 64
2011 66
2012 73
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1,698 results

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Page 1
Role of the Helix-8 and C-Terminal Tail in Regulating Proteinase Activated Receptor 2 Signaling.
Thibeault PE, Ramachandran R. Thibeault PE, et al. ACS Pharmacol Transl Sci. 2020 Aug 10;3(5):868-882. doi: 10.1021/acsptsci.0c00039. eCollection 2020 Oct 9. ACS Pharmacol Transl Sci. 2020. PMID: 33073187 Free PMC article.
The C-terminal tail of G-protein-coupled receptors (GPCR) contain important regulatory sites that enable interaction with intracellular signaling effectors. Here we examine the relative contribution of the C-tail serine/threonine phosphorylation sites (Ser(383-385), …
The C-terminal tail of G-protein-coupled receptors (GPCR) contain important regulatory sites that enable interaction with intracellul …
Light-induced remodeling of phytochrome B enables signal transduction by phytochrome-interacting factor.
Wang Z, Wang W, Zhao D, Song Y, Lin X, Shen M, Chi C, Xu B, Zhao J, Deng XW, Wang J. Wang Z, et al. Cell. 2024 Oct 31;187(22):6235-6250.e19. doi: 10.1016/j.cell.2024.09.005. Epub 2024 Sep 23. Cell. 2024. PMID: 39317197 Free article.
The resulting alpha-helical PHY tongue further disrupts the head-to-tail dimer of phyB in the dark-adapted state. These structural remodelings of phyB facilitate the induced-fit recognition of PIF6, consequently stabilizing the N-terminal extension domain and a head-to-hea …
The resulting alpha-helical PHY tongue further disrupts the head-to-tail dimer of phyB in the dark-adapted state. These structural re …
The N-terminal tail of hERG contains an amphipathic alpha-helix that regulates channel deactivation.
Ng CA, Hunter MJ, Perry MD, Mobli M, Ke Y, Kuchel PW, King GF, Stock D, Vandenberg JI. Ng CA, et al. PLoS One. 2011 Jan 13;6(1):e16191. doi: 10.1371/journal.pone.0016191. PLoS One. 2011. PMID: 21249148 Free PMC article.
Here we show that the solution NMR structure of the N-terminal 135 residues of hERG contains a previously described Per-Arnt-Sim (PAS) domain (residues 26-135) as well as an amphipathic alpha-helix (residues 13-23) and an initial unstructured segment (residues 2-9). Deleti …
Here we show that the solution NMR structure of the N-terminal 135 residues of hERG contains a previously described Per-Arnt-Sim (PAS) domai …
Topology Prediction Improvement of alpha-helical Transmembrane Proteins Through Helix-tail Modeling and Multiscale Deep Learning Fusion.
Feng SH, Zhang WX, Yang J, Yang Y, Shen HB. Feng SH, et al. J Mol Biol. 2020 Feb 14;432(4):1279-1296. doi: 10.1016/j.jmb.2019.12.007. Epub 2019 Dec 21. J Mol Biol. 2020. PMID: 31870850
This new protocol includes two submodules. The first module is transmembrane helix (TMH) prediction, which features the capability of accurately predicting TMH with the tail part through the incorporation of tail modeling. ...
This new protocol includes two submodules. The first module is transmembrane helix (TMH) prediction, which features the capability of …
The interactions in the carboxyl terminus of human 4-hydroxyphenylpyruvate dioxygenase are critical to mediate the conformation of the final helix and the tail to shield the active site for catalysis.
Lin JF, Sheih YL, Chang TC, Chang NY, Chang CW, Shen CP, Lee HJ. Lin JF, et al. PLoS One. 2013 Aug 9;8(8):e69733. doi: 10.1371/journal.pone.0069733. eCollection 2013. PLoS One. 2013. PMID: 23950902 Free PMC article.
Successive truncation of the disordered tail which follows the final alpha-helix resulted in no changes in the K m value for 4-HPP substrate but the k cat values were significantly reduced. ...These results highlight the critical role of Q375 in orientating the t …
Successive truncation of the disordered tail which follows the final alpha-helix resulted in no changes in the K m value for 4 …
Effect of head-to-tail cyclization on conformation of histatin-5.
Sikorska E, Kamysz E. Sikorska E, et al. J Pept Sci. 2014 Dec;20(12):952-7. doi: 10.1002/psc.2707. Epub 2014 Oct 31. J Pept Sci. 2014. PMID: 25358457
In the present work, we demonstrate the 3D structure of the head-to-tail cyclic variant of Hst-5 in TFE solution determined using NMR spectroscopy and molecular dynamics simulations. The cyclic histatin-5 reveals a helix-loop-helix motif with alpha-helices at …
In the present work, we demonstrate the 3D structure of the head-to-tail cyclic variant of Hst-5 in TFE solution determined using NMR …
A combination of an organic alloy and a heterojunction towards a rod-tail helix architecture with dual-color-emitting properties.
Zhang H , Wang H , Qian PC , Wong WY . Zhang H , et al. Nanoscale. 2020 Aug 21;12(31):16414-16419. doi: 10.1039/d0nr03948a. Epub 2020 Aug 4. Nanoscale. 2020. PMID: 32749439
Herein, we fabricate an unprecedented novel BA@BA(0.72)BN(0.28) heterostructure with a rod-tail helix configuration, in which the helical dual-component BA(0.72)BN(0.28) alloy can be grown in a controllable manner onto the mono-component BA microrod, forming an orga …
Herein, we fabricate an unprecedented novel BA@BA(0.72)BN(0.28) heterostructure with a rod-tail helix configuration, in which …
Angiotensinogen and the Modulation of Blood Pressure.
Shu Z, Wan J, Read RJ, Carrell RW, Zhou A. Shu Z, et al. Front Cardiovasc Med. 2021 Mar 18;8:645123. doi: 10.3389/fcvm.2021.645123. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 33816576 Free PMC article. Review.
A series of crystallographic structures of angiotensinogen and its derivative forms, together with its complexes with renin show in molecular detail how the interaction with renin triggers a profound shift of the amino-terminal tail of angiotensinogen with modulation occur …
A series of crystallographic structures of angiotensinogen and its derivative forms, together with its complexes with renin show in molecula …
Monomeric and dimeric conformation of the vinculin tail five-helix bundle in solution studied by EPR spectroscopy.
Abé C, Dietrich F, Gajula P, Benz M, Vogel KP, van Gastel M, Illenberger S, Ziegler WH, Steinhoff HJ. Abé C, et al. Biophys J. 2011 Oct 5;101(7):1772-80. doi: 10.1016/j.bpj.2011.08.048. Biophys J. 2011. PMID: 21961604 Free PMC article.
Interspin distances for a set of six singly and four doubly spin-labeled mutants of the tail domain of vinculin were determined and used as constraints for modeling of the vinculin tail dimer. ...Furthermore, the distance between positions 1033 is shown to increase …
Interspin distances for a set of six singly and four doubly spin-labeled mutants of the tail domain of vinculin were determined and u …
1,698 results