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124 results
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Patched acts catalytically to suppress the activity of Smoothened.
Taipale J, Cooper MK, Maiti T, Beachy PA. Taipale J, et al. Nature. 2002 Aug 22;418(6900):892-7. doi: 10.1038/nature00989. Nature. 2002. PMID: 12192414
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA. Taipale J, et al. Nature. 2000 Aug 31;406(6799):1005-9. doi: 10.1038/35023008. Nature. 2000. PMID: 10984056
The Hedgehog and Wnt signalling pathways in cancer.
Taipale J, Beachy PA. Taipale J, et al. Nature. 2001 May 17;411(6835):349-54. doi: 10.1038/35077219. Nature. 2001. PMID: 11357142 Review.
Divergence of hedgehog signal transduction mechanism between Drosophila and mammals.
Varjosalo M, Li SP, Taipale J. Varjosalo M, et al. Among authors: taipale j. Dev Cell. 2006 Feb;10(2):177-86. doi: 10.1016/j.devcel.2005.12.014. Dev Cell. 2006. PMID: 16459297
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.
Lum L, Zhang C, Oh S, Mann RK, von Kessler DP, Taipale J, Weis-Garcia F, Gong R, Wang B, Beachy PA. Lum L, et al. Among authors: taipale j. Mol Cell. 2003 Nov;12(5):1261-74. doi: 10.1016/s1097-2765(03)00426-x. Mol Cell. 2003. PMID: 14636583
A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis.
Cooper MK, Wassif CA, Krakowiak PA, Taipale J, Gong R, Kelley RI, Porter FD, Beachy PA. Cooper MK, et al. Among authors: taipale j. Nat Genet. 2003 Apr;33(4):508-13. doi: 10.1038/ng1134. Epub 2003 Mar 24. Nat Genet. 2003. PMID: 12652302
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
Chen JK, Taipale J, Cooper MK, Beachy PA. Chen JK, et al. Among authors: taipale j. Genes Dev. 2002 Nov 1;16(21):2743-8. doi: 10.1101/gad.1025302. Genes Dev. 2002. PMID: 12414725 Free PMC article.
Small molecule modulation of Smoothened activity.
Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. Chen JK, et al. Among authors: taipale j. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6. doi: 10.1073/pnas.182542899. Epub 2002 Oct 21. Proc Natl Acad Sci U S A. 2002. PMID: 12391318 Free PMC article.
Medulloblastoma growth inhibition by hedgehog pathway blockade.
Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK, Taipale J, Olson JM, Beachy PA. Berman DM, et al. Among authors: taipale j. Science. 2002 Aug 30;297(5586):1559-61. doi: 10.1126/science.1073733. Science. 2002. PMID: 12202832
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.
Ma Y, Erkner A, Gong R, Yao S, Taipale J, Basler K, Beachy PA. Ma Y, et al. Among authors: taipale j. Cell. 2002 Oct 4;111(1):63-75. doi: 10.1016/s0092-8674(02)00977-7. Cell. 2002. PMID: 12372301
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