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303 results
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Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.
Beglova N, Blacklow SC, Takagi J, Springer TA. Beglova N, et al. Among authors: takagi j. Nat Struct Biol. 2002 Apr;9(4):282-7. doi: 10.1038/nsb779. Nat Struct Biol. 2002. PMID: 11896403
Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface.
Takagi J, Yang Y, Liu JH, Wang JH, Springer TA. Takagi J, et al. Nature. 2003 Aug 21;424(6951):969-74. doi: 10.1038/nature01873. Nature. 2003. PMID: 12931195
Conformational regulation of integrin structure and function.
Shimaoka M, Takagi J, Springer TA. Shimaoka M, et al. Among authors: takagi j. Annu Rev Biophys Biomol Struct. 2002;31:485-516. doi: 10.1146/annurev.biophys.31.101101.140922. Epub 2001 Oct 25. Annu Rev Biophys Biomol Struct. 2002. PMID: 11988479 Review.
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.
Luo BH, Carman CV, Takagi J, Springer TA. Luo BH, et al. Among authors: takagi j. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3679-84. doi: 10.1073/pnas.0409440102. Epub 2005 Feb 28. Proc Natl Acad Sci U S A. 2005. PMID: 15738420 Free PMC article.
The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7.
Chen J, Takagi J, Xie C, Xiao T, Luo BH, Springer TA. Chen J, et al. Among authors: takagi j. J Biol Chem. 2004 Dec 31;279(53):55556-61. doi: 10.1074/jbc.M407773200. Epub 2004 Sep 24. J Biol Chem. 2004. PMID: 15448154 Free PMC article.
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics.
Xiao T, Takagi J, Coller BS, Wang JH, Springer TA. Xiao T, et al. Among authors: takagi j. Nature. 2004 Nov 4;432(7013):59-67. doi: 10.1038/nature02976. Epub 2004 Sep 19. Nature. 2004. PMID: 15378069 Free PMC article.
A specific interface between integrin transmembrane helices and affinity for ligand.
Luo BH, Springer TA, Takagi J. Luo BH, et al. Among authors: takagi j. PLoS Biol. 2004 Jun;2(6):e153. doi: 10.1371/journal.pbio.0020153. Epub 2004 Jun 15. PLoS Biol. 2004. PMID: 15208712 Free PMC article.
Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain.
Luo BH, Strokovich K, Walz T, Springer TA, Takagi J. Luo BH, et al. Among authors: takagi j. J Biol Chem. 2004 Jun 25;279(26):27466-71. doi: 10.1074/jbc.M404354200. Epub 2004 Apr 27. J Biol Chem. 2004. PMID: 15123676
Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.
Yang W, Shimaoka M, Salas A, Takagi J, Springer TA. Yang W, et al. Among authors: takagi j. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2906-11. doi: 10.1073/pnas.0307340101. Epub 2004 Feb 20. Proc Natl Acad Sci U S A. 2004. PMID: 14978279 Free PMC article.
Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides.
Luo BH, Takagi J, Springer TA. Luo BH, et al. Among authors: takagi j. J Biol Chem. 2004 Mar 12;279(11):10215-21. doi: 10.1074/jbc.M312732200. Epub 2003 Dec 16. J Biol Chem. 2004. PMID: 14681220
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