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The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function.
Yamaguchi T, Suzuki T, Sato T, Takahashi A, Watanabe H, Kadowaki A, Natsui M, Inagaki H, Arakawa S, Nakaoka S, Koizumi Y, Seki S, Adachi S, Fukao A, Fujiwara T, Natsume T, Kimura A, Komatsu M, Shimizu S, Ito H, Suzuki Y, Penninger JM, Yamamoto T, Imai Y, Kuba K. Yamaguchi T, et al. Among authors: takahashi a. Sci Signal. 2018 Feb 6;11(516):eaan3638. doi: 10.1126/scisignal.aan3638. Sci Signal. 2018. PMID: 29438013
Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.
Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N. Morita M, et al. Among authors: takahashi a. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7973-7981. doi: 10.1073/pnas.1816023116. Epub 2019 Mar 29. Proc Natl Acad Sci U S A. 2019. PMID: 30926667 Free PMC article.
The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation.
Takahashi A, Suzuki T, Soeda S, Takaoka S, Kobori S, Yamaguchi T, Mohamed HMA, Yanagiya A, Abe T, Shigeta M, Furuta Y, Kuba K, Yamamoto T. Takahashi A, et al. Life Sci Alliance. 2020 Apr 1;3(5):e201900494. doi: 10.26508/lsa.201900494. Print 2020 May. Life Sci Alliance. 2020. PMID: 32238456 Free PMC article.
4,811 results