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Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.
Nagai Y, Miyakawa N, Takuwa H, Hori Y, Oyama K, Ji B, Takahashi M, Huang XP, Slocum ST, DiBerto JF, Xiong Y, Urushihata T, Hirabayashi T, Fujimoto A, Mimura K, English JG, Liu J, Inoue KI, Kumata K, Seki C, Ono M, Shimojo M, Zhang MR, Tomita Y, Nakahara J, Suhara T, Takada M, Higuchi M, Jin J, Roth BL, Minamimoto T. Nagai Y, et al. Among authors: takahashi m. Nat Neurosci. 2020 Sep;23(9):1157-1167. doi: 10.1038/s41593-020-0661-3. Epub 2020 Jul 6. Nat Neurosci. 2020. PMID: 32632286
High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies.
Tagai K, Ono M, Kubota M, Kitamura S, Takahata K, Seki C, Takado Y, Shinotoh H, Sano Y, Yamamoto Y, Matsuoka K, Takuwa H, Shimojo M, Takahashi M, Kawamura K, Kikuchi T, Okada M, Akiyama H, Suzuki H, Onaya M, Takeda T, Arai K, Arai N, Araki N, Saito Y, Trojanowski JQ, Lee VMY, Mishra SK, Yamaguchi Y, Kimura Y, Ichise M, Tomita Y, Zhang MR, Suhara T, Shigeta M, Sahara N, Higuchi M, Shimada H. Tagai K, et al. Among authors: takahashi m. Neuron. 2021 Jan 6;109(1):42-58.e8. doi: 10.1016/j.neuron.2020.09.042. Epub 2020 Oct 29. Neuron. 2021. PMID: 33125873 Free article.
MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice.
Takado Y, Takuwa H, Sampei K, Urushihata T, Takahashi M, Shimojo M, Uchida S, Nitta N, Shibata S, Nagashima K, Ochi Y, Ono M, Maeda J, Tomita Y, Sahara N, Near J, Aoki I, Shibata K, Higuchi M. Takado Y, et al. Among authors: takahashi m. J Cereb Blood Flow Metab. 2022 Jan;42(1):197-212. doi: 10.1177/0271678X211045449. Epub 2021 Sep 13. J Cereb Blood Flow Metab. 2022. PMID: 34515548 Free PMC article.
A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains.
Shimojo M, Ono M, Takuwa H, Mimura K, Nagai Y, Fujinaga M, Kikuchi T, Okada M, Seki C, Tokunaga M, Maeda J, Takado Y, Takahashi M, Minamihisamatsu T, Zhang MR, Tomita Y, Suzuki N, Maximov A, Suhara T, Minamimoto T, Sahara N, Higuchi M. Shimojo M, et al. Among authors: takahashi m. EMBO J. 2021 Nov 15;40(22):e107757. doi: 10.15252/embj.2021107757. Epub 2021 Oct 12. EMBO J. 2021. PMID: 34636430 Free PMC article.
Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model.
Sato H, Takado Y, Toyoda S, Tsukamoto-Yasui M, Minatohara K, Takuwa H, Urushihata T, Takahashi M, Shimojo M, Ono M, Maeda J, Orihara A, Sahara N, Aoki I, Karakawa S, Isokawa M, Kawasaki N, Kawasaki M, Ueno S, Kanda M, Nishimura M, Suzuki K, Mitsui A, Nagao K, Kitamura A, Higuchi M. Sato H, et al. Among authors: takahashi m. Sci Adv. 2021 Oct 22;7(43):eabd5046. doi: 10.1126/sciadv.abd5046. Epub 2021 Oct 22. Sci Adv. 2021. PMID: 34678069 Free PMC article.
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