Takahashi N - Search Results

1

Discovery and SAR study of 2-(4-pyridylamino)thieno[3,2-d]pyrimidin-4(3H)-ones as soluble and highly potent PDE7 inhibitors.

Endo Y, Kawai K, Asano T, Amano S, Asanuma Y, Sawada K, Ogura K, Nagata N, Ueo N, Takahashi N, Sonoda Y, Kamei N. Endo Y, et al. Among authors: takahashi n. Bioorg Med Chem Lett. 2015 Feb 1;25(3):649-53. doi: 10.1016/j.bmcl.2014.11.090. Epub 2014 Dec 6. Bioorg Med Chem Lett. 2015. PMID: 25529739

2

Discovery of 2-(cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as a new series of potent phosphodiesterase 7 inhibitors.

Kawai K, Endo Y, Asano T, Amano S, Sawada K, Ueo N, Takahashi N, Sonoda Y, Nagai M, Kamei N, Nagata N. Kawai K, et al. Among authors: takahashi n. J Med Chem. 2014 Dec 11;57(23):9844-54. doi: 10.1021/jm5008215. Epub 2014 Nov 19. J Med Chem. 2014. PMID: 25383422

3

2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacy.

Endo Y, Kawai K, Asano T, Amano S, Asanuma Y, Sawada K, Onodera Y, Ueo N, Takahashi N, Sonoda Y, Kamei N, Irie T. Endo Y, et al. Among authors: takahashi n. Bioorg Med Chem Lett. 2015 May 1;25(9):1910-4. doi: 10.1016/j.bmcl.2015.03.031. Epub 2015 Mar 20. Bioorg Med Chem Lett. 2015. PMID: 25866242

4

Development of an anti-hepatitis B virus (HBV) agent through the structure-activity relationship of the interferon-like small compound CDM-3008.

Takahashi N, Hayashi K, Nakagawa Y, Furutani Y, Toguchi M, Shiozaki-Sato Y, Sudoh M, Kojima S, Kakeya H. Takahashi N, et al. Bioorg Med Chem. 2019 Feb 1;27(3):470-478. doi: 10.1016/j.bmc.2018.11.039. Epub 2018 Dec 5. Bioorg Med Chem. 2019. PMID: 30552008

5

Design and synthesis of Rho kinase inhibitors (I).

Takami A, Iwakubo M, Okada Y, Kawata T, Odai H, Takahashi N, Shindo K, Kimura K, Tagami Y, Miyake M, Fukushima K, Inagaki M, Amano M, Kaibuchi K, Iijima H. Takami A, et al. Among authors: takahashi n. Bioorg Med Chem. 2004 May 1;12(9):2115-37. doi: 10.1016/j.bmc.2004.02.025. Bioorg Med Chem. 2004. PMID: 15080913

6

Design, synthesis, and target identification of new hypoxia-inducible factor 1 (HIF-1) inhibitors containing 1-alkyl-1H-pyrazole-3-carboxamide moiety.

Sakai M, Takahashi N, Ikeda H, Furutani Y, Higuchi S, Suzuki T, Dohmae N, Kobayashi S, Harada H, Kojima S, Matsuura T, Hattori A, Kakeya H. Sakai M, et al. Among authors: takahashi n. Bioorg Med Chem. 2021 Sep 15;46:116375. doi: 10.1016/j.bmc.2021.116375. Epub 2021 Aug 30. Bioorg Med Chem. 2021. PMID: 34492592

7

Retro-aza-Michael reaction of an o-aminophenol adduct in protic solvents inspired by natural products.

Takenaka K, Kaneko K, Takahashi N, Nishimura S, Kakeya H. Takenaka K, et al. Among authors: takahashi n. Bioorg Med Chem. 2021 Apr 1;35:116059. doi: 10.1016/j.bmc.2021.116059. Epub 2021 Feb 13. Bioorg Med Chem. 2021. PMID: 33611014

8

Asymmetric total synthesis of novel pentacyclic indole alkaloid, kopsiyunnanine E, isolated from Kopsia arborea.

Kitajima M, Murakami Y, Takahashi N, Wu Y, Kogure N, Zhang RP, Takayama H. Kitajima M, et al. Among authors: takahashi n. Org Lett. 2014 Oct 3;16(19):5000-3. doi: 10.1021/ol502265q. Epub 2014 Sep 24. Org Lett. 2014. PMID: 25250658

9

Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1).

Takahashi N, Hayashi H, Poznaks V, Kakeya H. Takahashi N, et al. Chem Commun (Camb). 2019 Oct 1;55(79):11956-11959. doi: 10.1039/c9cc06169j. Chem Commun (Camb). 2019. PMID: 31531455

10

Determination of absolute configuration of trimeric indole alkaloid, psychotrimine, by first asymmetric total synthesis.

Takahashi N, Ito T, Matsuda Y, Kogure N, Kitajima M, Takayama H. Takahashi N, et al. Chem Commun (Camb). 2010 Apr 14;46(14):2501-3. doi: 10.1039/b923918a. Epub 2010 Feb 1. Chem Commun (Camb). 2010. PMID: 20309475

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