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Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via phosphatidylinositol 3-kinase/Akt/nuclear factor-kappaB cascade in human breast cancer cells.
Saitoh M, Ohmichi M, Takahashi K, Kawagoe J, Ohta T, Doshida M, Takahashi T, Igarashi H, Mori-Abe A, Du B, Tsutsumi S, Kurachi H. Saitoh M, et al. Among authors: takahashi k, takahashi t. Endocrinology. 2005 Nov;146(11):4917-25. doi: 10.1210/en.2004-1535. Epub 2005 Aug 25. Endocrinology. 2005. PMID: 16123159
Raloxifene inhibits estrogen-induced up-regulation of telomerase activity in a human breast cancer cell line.
Kawagoe J, Ohmichi M, Takahashi T, Ohshima C, Mabuchi S, Takahashi K, Igarashi H, Mori-Abe A, Saitoh M, Du B, Ohta T, Kimura A, Kyo S, Inoue M, Kurachi H. Kawagoe J, et al. Among authors: takahashi k, takahashi t. J Biol Chem. 2003 Oct 31;278(44):43363-72. doi: 10.1074/jbc.M304363200. Epub 2003 Aug 13. J Biol Chem. 2003. PMID: 12917431 Free article.
Both estrogen and raloxifene protect against beta-amyloid-induced neurotoxicity in estrogen receptor alpha-transfected PC12 cells by activation of telomerase activity via Akt cascade.
Du B, Ohmichi M, Takahashi K, Kawagoe J, Ohshima C, Igarashi H, Mori-Abe A, Saitoh M, Ohta T, Ohishi A, Doshida M, Tezuka N, Takahashi T, Kurachi H. Du B, et al. Among authors: takahashi k, takahashi t. J Endocrinol. 2004 Dec;183(3):605-15. doi: 10.1677/joe.1.05775. J Endocrinol. 2004. PMID: 15590986
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