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Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines.
Nochi T, Yuki Y, Takahashi H, Sawada S, Mejima M, Kohda T, Harada N, Kong IG, Sato A, Kataoka N, Tokuhara D, Kurokawa S, Takahashi Y, Tsukada H, Kozaki S, Akiyoshi K, Kiyono H. Nochi T, et al. Among authors: takahashi h, takahashi y. Nat Mater. 2010 Jul;9(7):572-8. doi: 10.1038/nmat2784. Epub 2010 Jun 20. Nat Mater. 2010. PMID: 20562880
A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity.
Nochi T, Yuki Y, Katakai Y, Shibata H, Tokuhara D, Mejima M, Kurokawa S, Takahashi Y, Nakanishi U, Ono F, Mimuro H, Sasakawa C, Takaiwa F, Terao K, Kiyono H. Nochi T, et al. Among authors: takahashi y. J Immunol. 2009 Nov 15;183(10):6538-44. doi: 10.4049/jimmunol.0901480. Epub 2009 Oct 30. J Immunol. 2009. PMID: 19880451
Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine.
Tokuhara D, Yuki Y, Nochi T, Kodama T, Mejima M, Kurokawa S, Takahashi Y, Nanno M, Nakanishi U, Takaiwa F, Honda T, Kiyono H. Tokuhara D, et al. Among authors: takahashi y. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8794-9. doi: 10.1073/pnas.0914121107. Epub 2010 Apr 26. Proc Natl Acad Sci U S A. 2010. PMID: 20421480 Free PMC article.
Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress.
Terahara K, Nochi T, Yoshida M, Takahashi Y, Goto Y, Hatai H, Kurokawa S, Jang MH, Kweon MN, Domino SE, Hiroi T, Yuki Y, Tsunetsugu-Yokota Y, Kobayashi K, Kiyono H. Terahara K, et al. Among authors: takahashi y. Biochem Biophys Res Commun. 2011 Jan 21;404(3):822-8. doi: 10.1016/j.bbrc.2010.12.067. Epub 2010 Dec 21. Biochem Biophys Res Commun. 2011. PMID: 21172308
Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification.
Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Takahashi Y, Tokuhara D, Nochi T, Katakai Y, Kuroda M, Takeyama N, Kashima K, Abe M, Chen Y, Nakanishi U, Masumura T, Takeuchi Y, Kozuka-Hata H, Shibata H, Oyama M, Tanaka K, Kiyono H. Yuki Y, et al. Among authors: takahashi y. Plant Biotechnol J. 2013 Sep;11(7):799-808. doi: 10.1111/pbi.12071. Epub 2013 Apr 22. Plant Biotechnol J. 2013. PMID: 23601492 Free article.
Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection.
Tokuhara D, Álvarez B, Mejima M, Hiroiwa T, Takahashi Y, Kurokawa S, Kuroda M, Oyama M, Kozuka-Hata H, Nochi T, Sagara H, Aladin F, Marcotte H, Frenken LG, Iturriza-Gómara M, Kiyono H, Hammarström L, Yuki Y. Tokuhara D, et al. Among authors: takahashi y. J Clin Invest. 2013 Sep;123(9):3829-38. doi: 10.1172/JCI70266. Epub 2013 Aug 8. J Clin Invest. 2013. PMID: 23925294 Free PMC article.
RNAi-mediated suppression of endogenous storage proteins leads to a change in localization of overexpressed cholera toxin B-subunit and the allergen protein RAG2 in rice seeds.
Kurokawa S, Kuroda M, Mejima M, Nakamura R, Takahashi Y, Sagara H, Takeyama N, Satoh S, Kiyono H, Teshima R, Masumura T, Yuki Y. Kurokawa S, et al. Among authors: takahashi y. Plant Cell Rep. 2014 Jan;33(1):75-87. doi: 10.1007/s00299-013-1513-3. Epub 2013 Oct 2. Plant Cell Rep. 2014. PMID: 24085308
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