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745 results
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Histogram analysis of pharmacokinetic parameters by bootstrap resampling from one-point sampling data in animal experiments.
Takemoto S, Yamaoka K, Nishikawa M, Takakura Y. Takemoto S, et al. Among authors: takakura y. Drug Metab Pharmacokinet. 2006 Dec;21(6):458-64. doi: 10.2133/dmpk.21.458. Drug Metab Pharmacokinet. 2006. PMID: 17220561
Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: importance of molecular size and negative charge density for in vivo recognition by receptors.
Yamasaki Y, Sumimoto K, Nishikawa M, Yamashita F, Yamaoka K, Hashida M, Takakura Y. Yamasaki Y, et al. Among authors: takakura y. J Pharmacol Exp Ther. 2002 May;301(2):467-77. doi: 10.1124/jpet.301.2.467. J Pharmacol Exp Ther. 2002. PMID: 11961045
Influence of physicochemical properties on pharmacokinetics of non-viral vectors for gene delivery.
Takakura Y, Nishikawa M, Yamashita F, Hashida M. Takakura Y, et al. J Drug Target. 2002 Mar;10(2):99-104. doi: 10.1080/10611860290016694. J Drug Target. 2002. PMID: 12074546 Review.
Pharmacokinetics and preventive effects of targeted catalase derivatives on hydrogen peroxide-induced injury in perfused rat liver.
Yabe Y, Kobayashi N, Nishikawa M, Mihara K, Yamashita F, Takakura Y, Hashida M. Yabe Y, et al. Among authors: takakura y. Pharm Res. 2002 Dec;19(12):1815-21. doi: 10.1023/a:1021485222920. Pharm Res. 2002. PMID: 12523659
Efficient scavenger receptor-mediated hepatic targeting of proteins by introduction of negative charges on the proteins by aconitylation: the influence of charge density and size of the proteins molecules.
Yamasaki Y, Hisazumi J, Yamaoka K, Takakura Y. Yamasaki Y, et al. Among authors: takakura y. Eur J Pharm Sci. 2003 Apr;18(5):305-12. doi: 10.1016/s0928-0987(03)00021-6. Eur J Pharm Sci. 2003. PMID: 12694882
Disposition and gene expression characteristics in solid tumors and skeletal muscle after direct injection of naked plasmid DNA in mice.
Kawase A, Nomura T, Yasuda K, Kobayashi N, Hashida M, Takakura Y. Kawase A, et al. Among authors: takakura y. J Pharm Sci. 2003 Jun;92(6):1295-304. doi: 10.1002/jps.10392. J Pharm Sci. 2003. PMID: 12761818
An evaluation method for nonlinear local disposition in rat liver and kidney.
Kato T, Yamaoka K, Takakura Y. Kato T, et al. Among authors: takakura y. Drug Metab Dispos. 2004 Feb;32(2):230-4. doi: 10.1124/dmd.32.2.230. Drug Metab Dispos. 2004. PMID: 14744945
Significant role of liver sinusoidal endothelial cells in hepatic uptake and degradation of naked plasmid DNA after intravenous injection.
Hisazumi J, Kobayashi N, Nishikawa M, Takakura Y. Hisazumi J, et al. Among authors: takakura y. Pharm Res. 2004 Jul;21(7):1223-8. doi: 10.1023/b:pham.0000033009.17594.e5. Pharm Res. 2004. PMID: 15290863
Effect of co-administration of cationic macromolecules on the in vivo disposition and in situ renal disposition characteristics of rhIL-11.
Takagi A, Yabe Y, Oka Y, Takakura Y, Hashida M. Takagi A, et al. Among authors: takakura y. Drug Metab Pharmacokinet. 2002;17(2):136-41. doi: 10.2133/dmpk.17.136. Drug Metab Pharmacokinet. 2002. PMID: 15618662
Analysis methods and recent advances in nonlinear pharmacokinetics from in vitro through in loci to in vivo.
Yamaoka K, Takakura Y. Yamaoka K, et al. Among authors: takakura y. Drug Metab Pharmacokinet. 2004 Dec;19(6):397-406. doi: 10.2133/dmpk.19.397. Drug Metab Pharmacokinet. 2004. PMID: 15681893 Review.
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