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IRF family of transcription factors as regulators of host defense.
Taniguchi T, Ogasawara K, Takaoka A, Tanaka N. Taniguchi T, et al. Among authors: takaoka a. Annu Rev Immunol. 2001;19:623-55. doi: 10.1146/annurev.immunol.19.1.623. Annu Rev Immunol. 2001. PMID: 11244049 Review.
Interferon regulatory factors (IRFs) constitute a family of transcription factors that commonly possess a novel helix-turn-helix DNA-binding motif. ...Thus far, intensive functional analyses have been done on IRF-1, revealing a remarkable functional diversity …
Interferon regulatory factors (IRFs) constitute a family of transcription factors that commonly possess a novel helix-turn-hel …
Cross talk of the interferon-alpha/beta signalling complex with gp130 for effective interleukin-6 signalling.
Mitani Y, Takaoka A, Kim SH, Kato Y, Yokochi T, Tanaka N, Taniguchi T. Mitani Y, et al. Among authors: takaoka a. Genes Cells. 2001 Jul;6(7):631-40. doi: 10.1046/j.1365-2443.2001.00448.x. Genes Cells. 2001. PMID: 11473581
BACKGROUND: Signalling cross talk provides a molecular basis for modulating a given signalling pathway by another, and it is often critical for regulating cellular responses elicited by cytokines. ...Furthermore, a chemical cross-linking experiment revealed t …
BACKGROUND: Signalling cross talk provides a molecular basis for modulating a given signalling pathway by another, and it is o …
Constitutive IFN-alpha/beta signal for efficient IFN-alpha/beta gene induction by virus.
Hata N, Sato M, Takaoka A, Asagiri M, Tanaka N, Taniguchi T. Hata N, et al. Among authors: takaoka a. Biochem Biophys Res Commun. 2001 Jul 13;285(2):518-25. doi: 10.1006/bbrc.2001.5159. Biochem Biophys Res Commun. 2001. PMID: 11444873
Efficient IFN-alpha/beta gene induction in virus-infected cells is an event central to innate immunity, in which the transcription factor IRF-7 plays a critical role together with IRF-3. ...Thus, the constitutive IFN-alpha/beta signal provides a foundation for the I …
Efficient IFN-alpha/beta gene induction in virus-infected cells is an event central to innate immunity, in which the transcription factor IR …
A weak signal for strong responses: interferon-alpha/beta revisited.
Taniguchi T, Takaoka A. Taniguchi T, et al. Among authors: takaoka a. Nat Rev Mol Cell Biol. 2001 May;2(5):378-86. doi: 10.1038/35073080. Nat Rev Mol Cell Biol. 2001. PMID: 11331912 Review.
A typical example is the immune system, which eradicates invading pathogens such as viruses. Interferons alpha and beta, which are produced in response to viral infection, are essential components of this system but are also produced at low levels in the absence of infecti
A typical example is the immune system, which eradicates invading pathogens such as viruses. Interferons alpha and beta, which are pr
Transcription factor IRF-1 and its family members in the regulation of host defense.
Taniguchi T, Tanaka N, Ogasawara K, Taki S, Sato M, Takaoka A. Taniguchi T, et al. Among authors: takaoka a. Cold Spring Harb Symp Quant Biol. 1999;64:465-72. doi: 10.1101/sqb.1999.64.465. Cold Spring Harb Symp Quant Biol. 1999. PMID: 11232323 Review. No abstract available.
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.
Takayanagi H, Ogasawara K, Hida S, Chiba T, Murata S, Sato K, Takaoka A, Yokochi T, Oda H, Tanaka K, Nakamura K, Taniguchi T. Takayanagi H, et al. Among authors: takaoka a. Nature. 2000 Nov 30;408(6812):600-5. doi: 10.1038/35046102. Nature. 2000. PMID: 11117749
Our study shows that there is cross-talk between the tumour necrosis factor and IFN families of cytokines, through which IFN-gamma provides a negative link between T-cell activation and bone resorption. Our results may offer a therapeutic approach to treat the infla …
Our study shows that there is cross-talk between the tumour necrosis factor and IFN families of cytokines, through which IFN-gamma provides …
Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains.
Takaoka A, Mitani Y, Suemori H, Sato M, Yokochi T, Noguchi S, Tanaka N, Taniguchi T. Takaoka A, et al. Science. 2000 Jun 30;288(5475):2357-60. doi: 10.1126/science.288.5475.2357. Science. 2000. PMID: 10875919
This cross talk is contingent on a constitutive subthreshold IFN-alpha/beta signaling and the association between the two nonligand-binding receptor components, IFNAR1 and IFNGR2, in the caveolar membrane domains. ...
This cross talk is contingent on a constitutive subthreshold IFN-alpha/beta signaling and the association between the two nonligand-b …
Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway.
Miyazaki T, Takaoka A, Nogueira L, Dikic I, Fujii H, Tsujino S, Mitani Y, Maeda M, Schlessinger J, Taniguchi T. Miyazaki T, et al. Among authors: takaoka a. Genes Dev. 1998 Mar 15;12(6):770-5. doi: 10.1101/gad.12.6.770. Genes Dev. 1998. PMID: 9512511 Free PMC article.
Here, the nonreceptor PTK, Pyk2, was found to be activated following IL-2 stimulation in a Jak-dependent manner. Furthermore, physical association was detected between endogenous Pyk2 and Jak3, and a dominant interfering mutant of Pyk2 inhibited IL-2-induced cell pr …
Here, the nonreceptor PTK, Pyk2, was found to be activated following IL-2 stimulation in a Jak-dependent manner. Furthermore, physica …
Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.
Takaoka A, Tanaka N, Mitani Y, Miyazaki T, Fujii H, Sato M, Kovarik P, Decker T, Schlessinger J, Taniguchi T. Takaoka A, et al. EMBO J. 1999 May 4;18(9):2480-8. doi: 10.1093/emboj/18.9.2480. EMBO J. 1999. PMID: 10228162 Free PMC article.
Overexpression of PKM, a dominant interfering form of Pyk2, in NIH 3T3 cells results in a strong inhibition of the IFN-gamma-induced activation of Erk2, serine phosphorylation of Stat1 and Stat1-dependent gene transcription. ...
Overexpression of PKM, a dominant interfering form of Pyk2, in NIH 3T3 cells results in a strong inhibition of the IFN-gamma-i …
Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.
Tsujino S, Di Santo JP, Takaoka A, McKernan TL, Noguchi S, Taya C, Yonekawa H, Saito T, Taniguchi T, Fujii H. Tsujino S, et al. Among authors: takaoka a. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10514-9. doi: 10.1073/pnas.180063297. Proc Natl Acad Sci U S A. 2000. PMID: 10962026 Free PMC article.
The common cytokine receptor gamma chain (gammac), a shared component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15, is critical for the development and function of lymphocytes. ...In the present study, we expressed mutant forms of gammac, which lack either most o …
The common cytokine receptor gamma chain (gammac), a shared component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15, is crit …
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