Takayama K - Search Results

1

Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.

Hayashi Y, Takeno H, Chinen T, Muguruma K, Okuyama K, Taguchi A, Takayama K, Yakushiji F, Miura M, Usui T, Hayashi Y. Hayashi Y, et al. Among authors: takayama k. ACS Med Chem Lett. 2014 Jul 23;5(10):1094-8. doi: 10.1021/ml5001883. eCollection 2014 Oct 9. ACS Med Chem Lett. 2014. PMID: 25313318 Free PMC article.

2

Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption.

Hayashi Y, Takayama K, Suehisa Y, Fujita T, Nguyen JT, Futaki S, Yamamoto A, Kiso Y. Hayashi Y, et al. Among authors: takayama k. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5129-32. doi: 10.1016/j.bmcl.2007.07.004. Epub 2007 Jul 7. Bioorg Med Chem Lett. 2007. PMID: 17662604

3

Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety.

Konno S, Thanigaimalai P, Yamamoto T, Nakada K, Kakiuchi R, Takayama K, Yamazaki Y, Yakushiji F, Akaji K, Kiso Y, Kawasaki Y, Chen SE, Freire E, Hayashi Y. Konno S, et al. Among authors: takayama k. Bioorg Med Chem. 2013 Jan 15;21(2):412-24. doi: 10.1016/j.bmc.2012.11.017. Epub 2012 Nov 24. Bioorg Med Chem. 2013. PMID: 23245752 Free PMC article.

4

Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: structure-activity relationship study.

Thanigaimalai P, Konno S, Yamamoto T, Koiwai Y, Taguchi A, Takayama K, Yakushiji F, Akaji K, Kiso Y, Kawasaki Y, Chen SE, Naser-Tavakolian A, Schön A, Freire E, Hayashi Y. Thanigaimalai P, et al. Among authors: takayama k. Eur J Med Chem. 2013 Jul;65:436-47. doi: 10.1016/j.ejmech.2013.05.005. Epub 2013 May 20. Eur J Med Chem. 2013. PMID: 23747811 Free PMC article.

5

Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: design, synthesis, biological evaluation, and docking studies.

Thanigaimalai P, Konno S, Yamamoto T, Koiwai Y, Taguchi A, Takayama K, Yakushiji F, Akaji K, Chen SE, Naser-Tavakolian A, Schön A, Freire E, Hayashi Y. Thanigaimalai P, et al. Among authors: takayama k. Eur J Med Chem. 2013 Oct;68:372-84. doi: 10.1016/j.ejmech.2013.07.037. Epub 2013 Aug 9. Eur J Med Chem. 2013. PMID: 23994330 Free PMC article.

6

Discovery of selective hexapeptide agonists to human neuromedin U receptors types 1 and 2.

Takayama K, Mori K, Taketa K, Taguchi A, Yakushiji F, Minamino N, Miyazato M, Kangawa K, Hayashi Y. Takayama K, et al. J Med Chem. 2014 Aug 14;57(15):6583-93. doi: 10.1021/jm500599s. Epub 2014 Jul 18. J Med Chem. 2014. PMID: 24999562

7

Discovery of natural products possessing selective eukaryotic readthrough activity: 3-epi-deoxynegamycin and its leucine adduct.

Taguchi A, Hamada K, Kotake M, Shiozuka M, Nakaminami H, Pillaiyar T, Takayama K, Yakushiji F, Noguchi N, Usui T, Matsuda R, Hayashi Y. Taguchi A, et al. Among authors: takayama k. ChemMedChem. 2014 Oct;9(10):2233-7. doi: 10.1002/cmdc.201402208. Epub 2014 Jul 9. ChemMedChem. 2014. PMID: 25044534

8

Identification of the minimum peptide from mouse myostatin prodomain for human myostatin inhibition.

Takayama K, Noguchi Y, Aoki S, Takayama S, Yoshida M, Asari T, Yakushiji F, Nishimatsu S, Ohsawa Y, Itoh F, Negishi Y, Sunada Y, Hayashi Y. Takayama K, et al. Among authors: takayama s. J Med Chem. 2015 Feb 12;58(3):1544-9. doi: 10.1021/jm501170d. Epub 2015 Jan 21. J Med Chem. 2015. PMID: 25569186

9

3-Nitro-2-pyridinesulfenyl-mediated solid-phase disulfide ligation in the synthesis of disulfide bond-containing cyclic peptides.

Taguchi A, Fukumoto K, Asahina Y, Kajiyama A, Shimura S, Hamada K, Takayama K, Yakushiji F, Hojo H, Hayashi Y. Taguchi A, et al. Among authors: takayama k. Org Biomol Chem. 2015 Mar 21;13(11):3186-9. doi: 10.1039/c5ob00030k. Org Biomol Chem. 2015. PMID: 25657109

10

Discovery of potent hexapeptide agonists to human neuromedin u receptor 1 and identification of their serum metabolites.

Takayama K, Mori K, Sohma Y, Taketa K, Taguchi A, Yakushiji F, Minamino N, Miyazato M, Kangawa K, Hayashi Y. Takayama K, et al. ACS Med Chem Lett. 2015 Jan 28;6(3):302-7. doi: 10.1021/ml500494j. eCollection 2015 Mar 12. ACS Med Chem Lett. 2015. PMID: 25815150 Free PMC article.

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