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The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus.
Kawai N, Sakai N, Okuro M, Karakawa S, Tsuneyoshi Y, Kawasaki N, Takeda T, Bannai M, Nishino S. Kawai N, et al. Among authors: Takeda T. Neuropsychopharmacology. 2015 May;40(6):1405-16. doi: 10.1038/npp.2014.326. Epub 2014 Dec 23. Neuropsychopharmacology. 2015. PMID: 25533534 Free PMC article.
Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity.
Yamamoto T, Niwa S, Iwayama S, Koganei H, Fujita S, Takeda T, Kito M, Ono Y, Saitou Y, Takahara A, Iwata S, Yamamoto H, Shoji M. Yamamoto T, et al. Among authors: Takeda T. Bioorg Med Chem. 2006 Aug 1;14(15):5333-9. doi: 10.1016/j.bmc.2006.03.040. Epub 2006 Apr 17. Bioorg Med Chem. 2006. PMID: 16616501
Asymmetric synthesis and biological evaluations of (+)- and (-)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels.
Yamamoto T, Ohno S, Niwa S, Tokumasu M, Hagihara M, Koganei H, Fujita S, Takeda T, Saitou Y, Iwayama S, Takahara A, Iwata S, Shoji M. Yamamoto T, et al. Among authors: Takeda T. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3317-9. doi: 10.1016/j.bmcl.2011.04.007. Epub 2011 Apr 9. Bioorg Med Chem Lett. 2011. PMID: 21514827
The key step is the stereoselective Michael addition using t-butyl ester of L-valine as a chiral auxiliary to achieve good ee (>95% for all the tested experiments) and moderate yield. ...
The key step is the stereoselective Michael addition using t-butyl ester of L-valine as a chiral auxiliary to achieve good ee (>95 …
Change of intestinal microbiota with elemental diet and its impact on therapeutic effects in a murine model of chronic colitis.
Kajiura T, Takeda T, Sakata S, Sakamoto M, Hashimoto M, Suzuki H, Suzuki M, Benno Y. Kajiura T, et al. Among authors: Takeda T. Dig Dis Sci. 2009 Sep;54(9):1892-900. doi: 10.1007/s10620-008-0574-6. Epub 2008 Dec 5. Dig Dis Sci. 2009. PMID: 19058004
In interleukin-10 (IL-10)-deficient cell-transferred mice, we investigated the change of intestinal microbiota with ED using molecular terminal-restriction fragment length polymorphism (T-RFLP) analysis and culture method, and evaluated its influence on therapeutic effects of ED. ...T-RFLP profiles of the ED group markedly differed from those of the regular diet groups. The diversity of bacterial species in the ED group decreased to 60% of that found in the regular diet groups. ...
In interleukin-10 (IL-10)-deficient cell-transferred mice, we investigated the change of intestinal microbiota with ED using molecular termi …
Discovery and evaluation of selective N-type calcium channel blockers: 6-unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives.
Yamamoto T, Niwa S, Tokumasu M, Onishi T, Ohno S, Hagihara M, Koganei H, Fujita S, Takeda T, Saitou Y, Iwayama S, Takahara A, Iwata S, Shoji M. Yamamoto T, et al. Among authors: Takeda T. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3639-42. doi: 10.1016/j.bmcl.2012.04.051. Epub 2012 Apr 17. Bioorg Med Chem Lett. 2012. PMID: 22560585
The structure-activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels.
Yamamoto T, Niwa S, Ohno S, Tokumasu M, Masuzawa Y, Nakanishi C, Nakajo A, Onishi T, Koganei H, Fujita S, Takeda T, Kito M, Ono Y, Saitou Y, Takahara A, Iwata S, Shoji M. Yamamoto T, et al. Among authors: Takeda T. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4813-6. doi: 10.1016/j.bmcl.2008.07.096. Epub 2008 Jul 27. Bioorg Med Chem Lett. 2008. PMID: 18684623
Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.
Yamamoto T, Niwa S, Ohno S, Onishi T, Matsueda H, Koganei H, Uneyama H, Fujita S, Takeda T, Kito M, Ono Y, Saitou Y, Takahara A, Iwata S, Shoji M. Yamamoto T, et al. Among authors: Takeda T. Bioorg Med Chem Lett. 2006 Feb 15;16(4):798-802. doi: 10.1016/j.bmcl.2005.11.021. Epub 2005 Nov 23. Bioorg Med Chem Lett. 2006. PMID: 16309909
Greater Amino Acid Intake Is Required to Maximize Whole-Body Protein Synthesis Immediately after Endurance Exercise Than at Rest in Endurance-Trained Rats, as Determined by an Indicator Amino Acid Oxidation Method.
Kato H, Nakano S, Inoue Y, Takeda T, Miura K, Nakamura T, Suzuki K, Bannai M. Kato H, et al. Among authors: Takeda T. J Nutr. 2016 Aug;146(8):1546-51. doi: 10.3945/jn.115.226373. Epub 2016 Jun 29. J Nutr. 2016. PMID: 27358420
Reasons for previous Cesarean deliveries impact a woman's independent decision of delivery mode and the success of trial of labor after Cesarean.
Uno K, Mayama M, Yoshihara M, Takeda T, Tano S, Suzuki T, Kishigami Y, Oguchi H. Uno K, et al. Among authors: Takeda T. BMC Pregnancy Childbirth. 2020 Mar 24;20(1):170. doi: 10.1186/s12884-020-2833-2. BMC Pregnancy Childbirth. 2020. PMID: 32204702 Free PMC article.
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