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Pattern recognition receptors and inflammation.
Takeuchi O, Akira S. Takeuchi O, et al. Cell. 2010 Mar 19;140(6):805-20. doi: 10.1016/j.cell.2010.01.022. Cell. 2010. PMID: 20303872 Review.
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S. Takeuchi O, et al. Immunity. 1999 Oct;11(4):443-51. doi: 10.1016/s1074-7613(00)80119-3. Immunity. 1999. PMID: 10549626
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades.
Takeuchi O, Takeda K, Hoshino K, Adachi O, Ogawa T, Akira S. Takeuchi O, et al. Int Immunol. 2000 Jan;12(1):113-7. doi: 10.1093/intimm/12.1.113. Int Immunol. 2000. PMID: 10607756
Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway.
Takeuchi O, Kaufmann A, Grote K, Kawai T, Hoshino K, Morr M, Mühlradt PF, Akira S. Takeuchi O, et al. J Immunol. 2000 Jan 15;164(2):554-7. doi: 10.4049/jimmunol.164.2.554. J Immunol. 2000. PMID: 10623793
Cytokine-inducing macromolecular glycolipids from Enterococcus hirae: improved method for separation and analysis of its effects on cellular activation.
Hashimoto M, Imamura Y, Morichika T, Arimoto K, Takeuchi O, Takeda K, Akira S, Aoyama K, Tamura T, Kotani S, Suda Y, Kusumoto S. Hashimoto M, et al. Among authors: takeuchi o. Biochem Biophys Res Commun. 2000 Jun 24;273(1):164-9. doi: 10.1006/bbrc.2000.2921. Biochem Biophys Res Commun. 2000. PMID: 10873580
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection.
Takeuchi O, Hoshino K, Akira S. Takeuchi O, et al. J Immunol. 2000 Nov 15;165(10):5392-6. doi: 10.4049/jimmunol.165.10.5392. J Immunol. 2000. PMID: 11067888
Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors.
Tsuji S, Matsumoto M, Takeuchi O, Akira S, Azuma I, Hayashi A, Toyoshima K, Seya T. Tsuji S, et al. Among authors: takeuchi o. Infect Immun. 2000 Dec;68(12):6883-90. doi: 10.1128/iai.68.12.6883-6890.2000. Infect Immun. 2000. PMID: 11083809 Free PMC article.
Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways.
Sato S, Nomura F, Kawai T, Takeuchi O, Mühlradt PF, Takeda K, Akira S. Sato S, et al. Among authors: takeuchi o. J Immunol. 2000 Dec 15;165(12):7096-101. doi: 10.4049/jimmunol.165.12.7096. J Immunol. 2000. PMID: 11120839
A Toll-like receptor recognizes bacterial DNA.
Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. Hemmi H, et al. Among authors: takeuchi o. Nature. 2000 Dec 7;408(6813):740-5. doi: 10.1038/35047123. Nature. 2000. PMID: 11130078
Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by Toll-like receptor 2: role of N-terminal hydrophobic portion in its multiple functions.
Nishiguchi M, Matsumoto M, Takao T, Hoshino M, Shimonishi Y, Tsuji S, Begum NA, Takeuchi O, Akira S, Toyoshima K, Seya T. Nishiguchi M, et al. Among authors: takeuchi o. J Immunol. 2001 Feb 15;166(4):2610-6. doi: 10.4049/jimmunol.166.4.2610. J Immunol. 2001. PMID: 11160323
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