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Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes.
Shukunami C, Takimoto A, Nishizaki Y, Yoshimoto Y, Tanaka S, Miura S, Watanabe H, Sakuma T, Yamamoto T, Kondoh G, Hiraki Y. Shukunami C, et al. Sci Rep. 2018 Feb 16;8(1):3155. doi: 10.1038/s41598-018-21194-3. Sci Rep. 2018. PMID: 29453333 Free PMC article.
Tenomodulin (Tnmd) is a type II transmembrane glycoprotein predominantly expressed in tendons and ligaments. We found that scleraxis (Scx), a member of the Twist-family of basic helix-loop-helix transcription factors, is a transcriptional activator of Tnmd expressio
Tenomodulin (Tnmd) is a type II transmembrane glycoprotein predominantly expressed in tendons and ligaments. We found that sclerax
Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes.
Shukunami C, Takimoto A, Oro M, Hiraki Y. Shukunami C, et al. Dev Biol. 2006 Oct 1;298(1):234-47. doi: 10.1016/j.ydbio.2006.06.036. Epub 2006 Jun 27. Dev Biol. 2006. PMID: 16876153 Free article.
Tenomodulin (TeM) is a type II transmembrane glycoprotein containing a C-terminal anti-angiogenic domain and is predominantly expressed in tendons and ligaments. Here we report that TeM expression is closely associated with the appearance of tenocytes during chick developm
Tenomodulin (TeM) is a type II transmembrane glycoprotein containing a C-terminal anti-angiogenic domain and is predominantly express
Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal components.
Shukunami C, Yoshimoto Y, Takimoto A, Yamashita H, Hiraki Y. Shukunami C, et al. Jpn Dent Sci Rev. 2016 Nov;52(4):84-92. doi: 10.1016/j.jdsr.2016.04.003. Epub 2016 Apr 27. Jpn Dent Sci Rev. 2016. PMID: 28408960 Free PMC article. Review.
Fibroblasts residing in tendons and ligaments are called tenocytes and ligamentocytes, respectively. Tenomodulin (Tnmd) is a type II transmembrane glycoprotein that is expressed at high levels in tenocytes and ligamentocytes, and is also present in periodontal ligament cel …
Fibroblasts residing in tendons and ligaments are called tenocytes and ligamentocytes, respectively. Tenomodulin (Tnmd) is a type II …
Direct conversion of tenocytes into chondrocytes by Sox9.
Takimoto A, Oro M, Hiraki Y, Shukunami C. Takimoto A, et al. Exp Cell Res. 2012 Aug 1;318(13):1492-507. doi: 10.1016/j.yexcr.2012.04.002. Epub 2012 Apr 10. Exp Cell Res. 2012. PMID: 22510437
Sox9 is abundantly expressed in cartilage but is undetectable in limb tendons that express Scleraxis (Scx) and Tenomodulin (Tnmd), tendon-specific early and late molecular markers, respectively. ...
Sox9 is abundantly expressed in cartilage but is undetectable in limb tendons that express Scleraxis (Scx) and Tenomodulin (Tn …
Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system.
Yoshimoto Y, Takimoto A, Watanabe H, Hiraki Y, Kondoh G, Shukunami C. Yoshimoto Y, et al. Sci Rep. 2017 Mar 22;7:45010. doi: 10.1038/srep45010. Sci Rep. 2017. PMID: 28327634 Free PMC article.
Scleraxis (Scx) is a basic helix-loop-helix transcription factor that is expressed persistently in tendons/ligaments, but transiently in entheseal cartilage. ...Reflecting the intensity and duration of endogenous expression, Cre-mediated excision occurs in tendinous and li
Scleraxis (Scx) is a basic helix-loop-helix transcription factor that is expressed persistently in tendons/ligaments, but transiently