Talaat R - Search Results

1

A novel approach for predicting acyl glucuronide reactivity via Schiff base formation: development of rapidly formed peptide adducts for LC/MS/MS measurements.

Wang J, Davis M, Li F, Azam F, Scatina J, Talaat R. Wang J, et al. Among authors: talaat r. Chem Res Toxicol. 2004 Sep;17(9):1206-16. doi: 10.1021/tx049900+. Chem Res Toxicol. 2004. PMID: 15377154

2

Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing.

Espina R, Yu L, Wang J, Tong Z, Vashishtha S, Talaat R, Scatina J, Mutlib A. Espina R, et al. Among authors: talaat r. Chem Res Toxicol. 2009 Feb;22(2):299-310. doi: 10.1021/tx800251p. Chem Res Toxicol. 2009. PMID: 18980340

3

Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards.

Vishwanathan K, Babalola K, Wang J, Espina R, Yu L, Adedoyin A, Talaat R, Mutlib A, Scatina J. Vishwanathan K, et al. Among authors: talaat r. Chem Res Toxicol. 2009 Feb;22(2):311-22. doi: 10.1021/tx8003328. Chem Res Toxicol. 2009. PMID: 19067650

4

Mechanism study of N-dephenylation mediated through a N-para-hydroxy metabolite.

Wang J, DeMaio W, Chandrasekaran A, Shen L, Bach AC 2nd, Scatina J, Talaat R. Wang J, et al. Among authors: talaat r. Curr Drug Discov Technol. 2006 Jun;3(2):101-14. doi: 10.2174/157016306778108901. Curr Drug Discov Technol. 2006. PMID: 16925518

5

Alternate strategies to obtain mass balance without the use of radiolabeled compounds: application of quantitative fluorine (19F) nuclear magnetic resonance (NMR) spectroscopy in metabolism studies.

Mutlib A, Espina R, Atherton J, Wang J, Talaat R, Scatina J, Chandrasekaran A. Mutlib A, et al. Among authors: talaat r. Chem Res Toxicol. 2012 Mar 19;25(3):572-83. doi: 10.1021/tx2005629. Epub 2012 Feb 10. Chem Res Toxicol. 2012. PMID: 22292524

6

Metabolism, excretion, and pharmacokinetics of [14C]tigecycline, a first-in-class glycylcycline antibiotic, after intravenous infusion to healthy male subjects.

Hoffmann M, DeMaio W, Jordan RA, Talaat R, Harper D, Speth J, Scatina J. Hoffmann M, et al. Among authors: talaat r. Drug Metab Dispos. 2007 Sep;35(9):1543-53. doi: 10.1124/dmd.107.015735. Epub 2007 May 30. Drug Metab Dispos. 2007. PMID: 17537869

7

Characterization of HKI-272 covalent binding to human serum albumin.

Wang J, Li-Chan XX, Atherton J, Deng L, Espina R, Yu L, Horwatt P, Ross S, Lockhead S, Ahmad S, Chandrasekaran A, Oganesian A, Scatina J, Mutlib A, Talaat R. Wang J, et al. Among authors: talaat r. Drug Metab Dispos. 2010 Jul;38(7):1083-93. doi: 10.1124/dmd.110.032292. Epub 2010 Apr 16. Drug Metab Dispos. 2010. PMID: 20400660

8

Liquid chromatography/mass spectrometry determination of endogenous plasma acetyl and palmitoyl carnitines as potential biomarkers of beta-oxidation in mice.

Liu Z, Mutlib AE, Wang J, Talaat RE. Liu Z, et al. Rapid Commun Mass Spectrom. 2008 Nov;22(21):3434-42. doi: 10.1002/rcm.3755. Rapid Commun Mass Spectrom. 2008. PMID: 18837479

9

Metabolism of intravenous methylnaltrexone in mice, rats, dogs, and humans.

Chandrasekaran A, Tong Z, Li H, Erve JC, DeMaio W, Goljer I, McConnell O, Rotshteyn Y, Hultin T, Talaat R, Scatina J. Chandrasekaran A, et al. Among authors: talaat r. Drug Metab Dispos. 2010 Apr;38(4):606-16. doi: 10.1124/dmd.109.031179. Epub 2010 Jan 6. Drug Metab Dispos. 2010. PMID: 20053817 Clinical Trial.

10

In vitro metabolism and identification of human enzymes involved in the metabolism of methylnaltrexone.

Tong Z, Chandrasekaran A, Li H, Rotshteyn Y, Erve JC, Demaio W, Talaat R, Hultin T, Scatina J. Tong Z, et al. Among authors: talaat r. Drug Metab Dispos. 2010 May;38(5):801-7. doi: 10.1124/dmd.110.032169. Epub 2010 Feb 19. Drug Metab Dispos. 2010. PMID: 20173089

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