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Mechanisms of induction of enzymes that protect against chemical carcinogenesis.
Talalay P. Talalay P. Adv Enzyme Regul. 1989;28:237-50. doi: 10.1016/0065-2571(89)90074-5. Adv Enzyme Regul. 1989. PMID: 2696344 Review.
., phenolic antioxidants, isothiocyanates, coumarins, thiocarbamates, cinnamates, 1,2-dithiol-3-thiones) that elevate Phase II enzymes (such as glutathione S-transferases, NAD(P)H:quinone reductase, UDP-glucuronosyl-transferases) in various tissues without significantly ra …
., phenolic antioxidants, isothiocyanates, coumarins, thiocarbamates, cinnamates, 1,2-dithiol-3-thiones) that elevate Phase II enzymes (such …
Elevation of quinone reductase activity by anticarcinogenic antioxidants.
Talalay P, Benson AM. Talalay P, et al. Adv Enzyme Regul. 1982;20:287-300. doi: 10.1016/0065-2571(82)90021-8. Adv Enzyme Regul. 1982. PMID: 6180607 Review.
NAD(P)H:quinone reductase exhibits broad specificity in the reduction of endogenous and exogenous quinones and quinone imines, such as those derived from polycyclic aromatic carcinogens, phenolic steroids, vitamin K, and numerous therapeutic drugs. ...
NAD(P)H:quinone reductase exhibits broad specificity in the reduction of endogenous and exogenous quinones and quinone imines, such a …
Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention.
Liu H, Talalay P. Liu H, et al. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19065-70. doi: 10.1073/pnas.1318247110. Epub 2013 Nov 4. Proc Natl Acad Sci U S A. 2013. PMID: 24191056 Free PMC article.
We show here that exemestane transcriptionally activates NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1), typical chemoprotective gene products, in a wide variety of mouse, rat, and human cells. ...
We show here that exemestane transcriptionally activates NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1), typical …
Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.
Dinkova-Kostova AT, Fahey JW, Benedict AL, Jenkins SN, Ye L, Wehage SL, Talalay P. Dinkova-Kostova AT, et al. Photochem Photobiol Sci. 2010 Apr;9(4):597-600. doi: 10.1039/b9pp00130a. Photochem Photobiol Sci. 2010. PMID: 20354656 Free PMC article.
Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1).
Dinkova-Kostova AT, Fahey JW, Talalay P. Dinkova-Kostova AT, et al. Methods Enzymol. 2004;382:423-48. doi: 10.1016/S0076-6879(04)82023-8. Methods Enzymol. 2004. PMID: 15047115 Review. No abstract available.
Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage.
Gao X, Talalay P. Gao X, et al. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10446-51. doi: 10.1073/pnas.0403886101. Epub 2004 Jun 30. Proc Natl Acad Sci U S A. 2004. PMID: 15229324 Free PMC article.
The degree of protection was correlated with the potencies of these inducers in elevating cytoprotective glutathione levels and activities of NAD(P)H:quinone oxidoreductase. In embryonic fibroblasts derived from mice in which the genes for the transcription factor Nrf2, th …
The degree of protection was correlated with the potencies of these inducers in elevating cytoprotective glutathione levels and activities o …
Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.
Dinkova-Kostova AT, Fahey JW, Wade KL, Jenkins SN, Shapiro TA, Fuchs EJ, Kerns ML, Talalay P. Dinkova-Kostova AT, et al. Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51. doi: 10.1158/1055-9965.EPI-06-0934. Cancer Epidemiol Biomarkers Prev. 2007. PMID: 17416783
Topical application of an extract delivering 100 nmol sulforaphane/cm(2) increased the protein levels of NAD(P)H:quinone oxidoreductase 1 (NQO1), glutathione S-transferase A1, and heme oxygenase 1, three representative phase 2 enzymes, in mouse skin epidermis. ...
Topical application of an extract delivering 100 nmol sulforaphane/cm(2) increased the protein levels of NAD(P)H:quinone oxidoreducta …
Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts.
Dinkova-Kostova AT, Jenkins SN, Fahey JW, Ye L, Wehage SL, Liby KT, Stephenson KK, Wade KL, Talalay P. Dinkova-Kostova AT, et al. Cancer Lett. 2006 Aug 28;240(2):243-52. doi: 10.1016/j.canlet.2005.09.012. Epub 2005 Nov 3. Cancer Lett. 2006. PMID: 16271437
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