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Biomarker-Guided Strategy for Treatment of Autism Spectrum Disorder (ASD).
Liu H, Talalay P, Fahey JW. Liu H, et al. Among authors: talalay p. CNS Neurol Disord Drug Targets. 2016;15(5):602-13. doi: 10.2174/1871527315666160413120414. CNS Neurol Disord Drug Targets. 2016. PMID: 27071792 Review.
Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention.
Healy ZR, Liu H, Holtzclaw WD, Talalay P. Healy ZR, et al. Among authors: talalay p. Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1516-23. doi: 10.1158/1055-9965.EPI-11-0279. Epub 2011 May 20. Cancer Epidemiol Biomarkers Prev. 2011. PMID: 21602309 Free PMC article.
Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways.
Brown RH, Reynolds C, Brooker A, Talalay P, Fahey JW. Brown RH, et al. Among authors: talalay p. Respir Res. 2015 Sep 15;16(1):106. doi: 10.1186/s12931-015-0253-z. Respir Res. 2015. PMID: 26369337 Free PMC article. Clinical Trial.
RESULTS: Sulforaphane ameliorated the bronchoconstrictor effects of MCh on FEV1 significantly (on average by 21 %; p = 0.01) in 60 % of these asthmatics. ...
RESULTS: Sulforaphane ameliorated the bronchoconstrictor effects of MCh on FEV1 significantly (on average by 21 %; p = 0.01) in 60 % …
Reply to Scahill: Behavioral outcome measures in autism.
Talalay P, Zimmerman AW. Talalay P, et al. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E350. doi: 10.1073/pnas.1422473112. Epub 2015 Jan 13. Proc Natl Acad Sci U S A. 2015. PMID: 25587137 Free PMC article. No abstract available.
Sulforaphane treatment of autism spectrum disorder (ASD).
Singh K, Connors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, Zimmerman AW. Singh K, et al. Among authors: talalay p. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15550-5. doi: 10.1073/pnas.1416940111. Epub 2014 Oct 13. Proc Natl Acad Sci U S A. 2014. PMID: 25313065 Free PMC article. Clinical Trial.

After 18 wk, participants receiving placebo experienced minimal change (<3.3%), whereas those receiving sulforaphane showed substantial declines (improvement of behavior): 34% for ABC (P < 0.001, comparing treatments) and 17% for SRS scores (P = 0.017). On CGI

After 18 wk, participants receiving placebo experienced minimal change (<3.3%), whereas those receiving sulforaphane showed substantial d …
Sulforaphane from Broccoli Reduces Symptoms of Autism: A Follow-up Case Series from a Randomized Double-blind Study.
Lynch R, Diggins EL, Connors SL, Zimmerman AW, Singh K, Liu H, Talalay P, Fahey JW. Lynch R, et al. Among authors: talalay p. Glob Adv Health Med. 2017 Oct 26;6:2164957X17735826. doi: 10.1177/2164957X17735826. eCollection 2017. Glob Adv Health Med. 2017. PMID: 29147630 Free PMC article.
Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency.
Fahey JW, Wade KL, Wehage SL, Holtzclaw WD, Liu H, Talalay P, Fuchs E, Stephenson KK. Fahey JW, et al. Among authors: talalay p. Mol Nutr Food Res. 2017 Apr;61(4). doi: 10.1002/mnfr.201600766. Epub 2017 Feb 8. Mol Nutr Food Res. 2017. PMID: 27935214
Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.
Liu H, Dinkova-Kostova AT, Talalay P. Liu H, et al. Among authors: talalay p. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15926-31. doi: 10.1073/pnas.0808346105. Epub 2008 Oct 6. Proc Natl Acad Sci U S A. 2008. PMID: 18838692 Free PMC article.
Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex.
Kerns ML, DePianto D, Dinkova-Kostova AT, Talalay P, Coulombe PA. Kerns ML, et al. Among authors: talalay p. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14460-5. doi: 10.1073/pnas.0706486104. Epub 2007 Aug 27. Proc Natl Acad Sci U S A. 2007. PMID: 17724334 Free PMC article.
Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention.
Liu H, Talalay P. Liu H, et al. Among authors: talalay p. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19065-70. doi: 10.1073/pnas.1318247110. Epub 2013 Nov 4. Proc Natl Acad Sci U S A. 2013. PMID: 24191056 Free PMC article.
We show here that exemestane transcriptionally activates NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1), typical chemoprotective gene products, in a wide variety of mouse, rat, and human cells. ...
We show here that exemestane transcriptionally activates NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1), typical …
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