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Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.
Fahey JW, Zhang Y, Talalay P. Fahey JW, et al. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10367-72. doi: 10.1073/pnas.94.19.10367. Proc Natl Acad Sci U S A. 1997. PMID: 9294217 Free PMC article.
., glutathione transferases, epoxide hydrolase, NAD(P)H: quinone reductase, and glucuronosyltransferases] is a powerful strategy for achieving protection against carcinogenesis, mutagenesis, and other forms of toxicity of electrophiles and reactive forms of oxygen. ...
., glutathione transferases, epoxide hydrolase, NAD(P)H: quinone reductase, and glucuronosyltransferases] is a powerful strategy for …
Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora.
Fahey JW, Wehage SL, Holtzclaw WD, Kensler TW, Egner PA, Shapiro TA, Talalay P. Fahey JW, et al. Cancer Prev Res (Phila). 2012 Apr;5(4):603-11. doi: 10.1158/1940-6207.CAPR-11-0538. Epub 2012 Feb 7. Cancer Prev Res (Phila). 2012. PMID: 22318753 Free PMC article.
Isolation and sequencing of the gene encoding delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni: overexpression of the protein.
Kuliopulos A, Shortle D, Talalay P. Kuliopulos A, et al. Proc Natl Acad Sci U S A. 1987 Dec;84(24):8893-7. doi: 10.1073/pnas.84.24.8893. Proc Natl Acad Sci U S A. 1987. PMID: 3480517 Free PMC article.
A genomic library of P. testosteroni total DNA constructed from partial EcoRI digests ligated to a lambda gtWES vector was probed with a 23-base oligonucleotide mixture [ATGAAC(T)ACC(A,T)CCG(C,A)GAG(A)CAC(T)ATGAC] corresponding to the NH2-terminal sequence of steroid isome …
A genomic library of P. testosteroni total DNA constructed from partial EcoRI digests ligated to a lambda gtWES vector was probed wit …
NMR evidence for the participation of a low-barrier hydrogen bond in the mechanism of delta 5-3-ketosteroid isomerase.
Zhao Q, Abeygunawardana C, Talalay P, Mildvan AS. Zhao Q, et al. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8220-4. doi: 10.1073/pnas.93.16.8220. Proc Natl Acad Sci U S A. 1996. PMID: 8710850 Free PMC article.
Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention.
Liu H, Talalay P. Liu H, et al. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19065-70. doi: 10.1073/pnas.1318247110. Epub 2013 Nov 4. Proc Natl Acad Sci U S A. 2013. PMID: 24191056 Free PMC article.
We show here that exemestane transcriptionally activates NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1), typical chemoprotective gene products, in a wide variety of mouse, rat, and human cells. ...
We show here that exemestane transcriptionally activates NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1), typical …
Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates.
Fahey JW, Stephenson KK, Wade KL, Talalay P. Fahey JW, et al. Biochem Biophys Res Commun. 2013 May 24;435(1):1-7. doi: 10.1016/j.bbrc.2013.03.126. Epub 2013 Apr 11. Biochem Biophys Res Commun. 2013. PMID: 23583386 Free PMC article.
Neuroprotective effects of sulforaphane after contusive spinal cord injury.
Benedict AL, Mountney A, Hurtado A, Bryan KE, Schnaar RL, Dinkova-Kostova AT, Talalay P. Benedict AL, et al. J Neurotrauma. 2012 Nov 1;29(16):2576-86. doi: 10.1089/neu.2012.2474. Epub 2012 Sep 20. J Neurotrauma. 2012. PMID: 22853439 Free PMC article.
Sulforaphane (SF), an isothiocyanate derived from broccoli, is a potent naturally-occurring inducer of the Keap1/Nrf2/ARE pathway, leading to upregulation of genes encoding cytoprotective proteins such as NAD(P)H: quinone oxidoreductase 1, and GSH-regulatory enzymes. ...
Sulforaphane (SF), an isothiocyanate derived from broccoli, is a potent naturally-occurring inducer of the Keap1/Nrf2/ARE pathway, leading t …
Electrophilic tuning of the chemoprotective natural product sulforaphane.
Ahn YH, Hwang Y, Liu H, Wang XJ, Zhang Y, Stephenson KK, Boronina TN, Cole RN, Dinkova-Kostova AT, Talalay P, Cole PA. Ahn YH, et al. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9590-5. doi: 10.1073/pnas.1004104107. Epub 2010 May 3. Proc Natl Acad Sci U S A. 2010. PMID: 20439747 Free PMC article.
Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.
Dinkova-Kostova AT, Fahey JW, Benedict AL, Jenkins SN, Ye L, Wehage SL, Talalay P. Dinkova-Kostova AT, et al. Photochem Photobiol Sci. 2010 Apr;9(4):597-600. doi: 10.1039/b9pp00130a. Photochem Photobiol Sci. 2010. PMID: 20354656 Free PMC article.
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