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11 results
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Thiol-dependent enzymes and their inhibitors: a review.
Leung-Toung R, Li W, Tam TF, Karimian K. Leung-Toung R, et al. Among authors: tam tf. Curr Med Chem. 2002 May;9(9):979-1002. doi: 10.2174/0929867024606704. Curr Med Chem. 2002. PMID: 11966457 Review.
Thiol proteases: inhibitors and potential therapeutic targets.
Leung-Toung R, Zhao Y, Li W, Tam TF, Karimian K, Spino M. Leung-Toung R, et al. Among authors: tam tf. Curr Med Chem. 2006;13(5):547-81. doi: 10.2174/092986706776055733. Curr Med Chem. 2006. PMID: 16515521 Review.
Synthesis of 3-substituted bicyclic imidazo[1,2-d][1,2,4]thiadiazoles and tricyclic benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazoles.
Leung-Toung R, Tam TF, Zhao Y, Simpson CD, Li W, Desilets D, Karimian K. Leung-Toung R, et al. Among authors: tam tf. J Org Chem. 2005 Aug 5;70(16):6230-41. doi: 10.1021/jo0507486. J Org Chem. 2005. PMID: 16050682
3-Substituted imidazo[1,2-d][1,2,4]-thiadiazoles: a novel class of factor XIIIa inhibitors.
Leung-Toung R, Tam TF, Wodzinska JM, Zhao Y, Lowrie J, Simpson CD, Karimian K, Spino M. Leung-Toung R, et al. Among authors: tam tf. J Med Chem. 2005 Apr 7;48(7):2266-9. doi: 10.1021/jm049221w. J Med Chem. 2005. PMID: 15801818
Iron chelator research: past, present, and future.
Tam TF, Leung-Toung R, Li W, Wang Y, Karimian K, Spino M. Tam TF, et al. Curr Med Chem. 2003 Jun;10(12):983-95. doi: 10.2174/0929867033457593. Curr Med Chem. 2003. PMID: 12678671 Review.
1,2,4-thiadiazole: a novel Cathepsin B inhibitor.
Leung-Toung R, Wodzinska J, Li W, Lowrie J, Kukreja R, Desilets D, Karimian K, Tam TF. Leung-Toung R, et al. Among authors: tam tf. Bioorg Med Chem. 2003 Dec 1;11(24):5529-37. doi: 10.1016/j.bmc.2003.09.040. Bioorg Med Chem. 2003. PMID: 14642597
Medicinal chemistry and properties of 1,2,4-thiadiazoles.
Tam TF, Leung-Toung R, Li W, Spino M, Karimian K. Tam TF, et al. Mini Rev Med Chem. 2005 Apr;5(4):367-79. doi: 10.2174/1389557053544056. Mini Rev Med Chem. 2005. PMID: 15853627 Review.
Intriguing structure-activity relations underlie the potent inhibition of HIV protease by norstatine-based peptides.
Tam TF, Carrière J, MacDonald D, Castelhano AL, Pliura DH, Dewdney NJ, Thomas EM, Bach C, Barnett J, Chan H, et al. Tam TF, et al. J Med Chem. 1992 Apr 3;35(7):1318-20. doi: 10.1021/jm00085a020. J Med Chem. 1992. PMID: 1560443 No abstract available.
Design and synthesis of 4H-3,1-benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase.
Krantz A, Spencer RW, Tam TF, Liak TJ, Copp LJ, Thomas EM, Rafferty SP. Krantz A, et al. Among authors: tam tf. J Med Chem. 1990 Feb;33(2):464-79. doi: 10.1021/jm00164a002. J Med Chem. 1990. PMID: 2299617
Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation.
Krantz A, Spencer RW, Tam TF, Thomas E, Copp LJ. Krantz A, et al. Among authors: tam tf. J Med Chem. 1987 Apr;30(4):489-91. doi: 10.1021/jm00387a001. J Med Chem. 1987. PMID: 3550086 No abstract available.
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