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Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid-Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration.
Zeng H, Li D, Qin X, Chen P, Tan H, Zeng X, Li X, Fan X, Jiang Y, Zhou Y, Chen Y, Wang Y, Huang M, Bi H. Zeng H, et al. Drug Metab Dispos. 2016 Mar;44(3):337-42. doi: 10.1124/dmd.115.066969. Epub 2015 Dec 10. Drug Metab Dispos. 2016. PMID: 26658429
Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine.
Fan X, Chen P, Jiang Y, Wang Y, Tan H, Zeng H, Wang Y, Qu A, Gonzalez FJ, Huang M, Bi H. Fan X, et al. Drug Metab Dispos. 2015 Mar;43(3):317-24. doi: 10.1124/dmd.114.062067. Epub 2014 Dec 22. Drug Metab Dispos. 2015. PMID: 25534769 Free PMC article.
Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways.
Fan X, Jiang Y, Wang Y, Tan H, Zeng H, Wang Y, Chen P, Qu A, Gonzalez FJ, Huang M, Bi H. Fan X, et al. Drug Metab Dispos. 2014 Dec;42(12):1982-90. doi: 10.1124/dmd.114.059535. Epub 2014 Sep 12. Drug Metab Dispos. 2014. PMID: 25217484 Free PMC article.
Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype.
Tan WLW, Anene-Nzelu CG, Wong E, Lee M, Tan HS, Tang SJ, Perrin AMY, Wu KX, Zheng WH, Ashburn RJ, Pan B, Lee MY, Autio MI, Morley M, Tam WL, Cheung C, Margulies KB, Chen L, Cappola TP, Loh M, Chambers J, Prabhakar S, Foo RS. Tan WLW, et al. Among authors: Tan HS. Circ Res. 2020 Jun 12. doi: 10.1161/CIRCRESAHA.120.317254. Online ahead of print. Circ Res. 2020. PMID: 32529949
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