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Regulatory T cells in cancer immunotherapy.
Tanaka A, Sakaguchi S. Tanaka A, et al. Cell Res. 2017 Jan;27(1):109-118. doi: 10.1038/cr.2016.151. Epub 2016 Dec 20. Cell Res. 2017. PMID: 27995907 Free PMC article. Review.
CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.
Kidani Y, Nogami W, Yasumizu Y, Kawashima A, Tanaka A, Sonoda Y, Tona Y, Nashiki K, Matsumoto R, Hagiwara M, Osaki M, Dohi K, Kanazawa T, Ueyama A, Yoshikawa M, Yoshida T, Matsumoto M, Hojo K, Shinonome S, Yoshida H, Hirata M, Haruna M, Nakamura Y, Motooka D, Okuzaki D, Sugiyama Y, Kinoshita M, Okuno T, Kato T, Hatano K, Uemura M, Imamura R, Yokoi K, Tanemura A, Shintani Y, Kimura T, Nonomura N, Wada H, Mori M, Doki Y, Ohkura N, Sakaguchi S. Kidani Y, et al. Among authors: tanaka a. Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):e2114282119. doi: 10.1073/pnas.2114282119. Proc Natl Acad Sci U S A. 2022. PMID: 35140181 Free PMC article.
PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment.
Thumkeo D, Punyawatthananukool S, Prasongtanakij S, Matsuura R, Arima K, Nie H, Yamamoto R, Aoyama N, Hamaguchi H, Sugahara S, Takeda S, Charoensawan V, Tanaka A, Sakaguchi S, Narumiya S. Thumkeo D, et al. Among authors: tanaka a. Cell Rep. 2022 Jun 7;39(10):110914. doi: 10.1016/j.celrep.2022.110914. Cell Rep. 2022. PMID: 35675777 Free article.
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer.
Kamada T, Togashi Y, Tay C, Ha D, Sasaki A, Nakamura Y, Sato E, Fukuoka S, Tada Y, Tanaka A, Morikawa H, Kawazoe A, Kinoshita T, Shitara K, Sakaguchi S, Nishikawa H. Kamada T, et al. Among authors: tanaka a. Proc Natl Acad Sci U S A. 2019 May 14;116(20):9999-10008. doi: 10.1073/pnas.1822001116. Epub 2019 Apr 26. Proc Natl Acad Sci U S A. 2019. PMID: 31028147 Free PMC article.
Targeting Treg cells in cancer immunotherapy.
Tanaka A, Sakaguchi S. Tanaka A, et al. Eur J Immunol. 2019 Aug;49(8):1140-1146. doi: 10.1002/eji.201847659. Epub 2019 Jul 5. Eur J Immunol. 2019. PMID: 31257581 Free article. Review.
Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells.
Tanaka A, Nishikawa H, Noguchi S, Sugiyama D, Morikawa H, Takeuchi Y, Ha D, Shigeta N, Kitawaki T, Maeda Y, Saito T, Shinohara Y, Kameoka Y, Iwaisako K, Monma F, Ohishi K, Karbach J, Jäger E, Sawada K, Katayama N, Takahashi N, Sakaguchi S. Tanaka A, et al. J Exp Med. 2020 Feb 3;217(2):e20191009. doi: 10.1084/jem.20191009. J Exp Med. 2020. PMID: 31704808 Free PMC article.
Regulatory T Cells and Human Disease.
Sakaguchi S, Mikami N, Wing JB, Tanaka A, Ichiyama K, Ohkura N. Sakaguchi S, et al. Among authors: tanaka a. Annu Rev Immunol. 2020 Apr 26;38:541-566. doi: 10.1146/annurev-immunol-042718-041717. Epub 2020 Feb 4. Annu Rev Immunol. 2020. PMID: 32017635 Review.
Dynamics of effector and naïve Regulatory T cells throughout pregnancy.
Shigeta N, Kumasawa K, Tanaka A, Badger Wing J, Nakamura H, Sakaguchi S, Kimura T. Shigeta N, et al. Among authors: tanaka a. J Reprod Immunol. 2020 Aug;140:103135. doi: 10.1016/j.jri.2020.103135. Epub 2020 Apr 19. J Reprod Immunol. 2020. PMID: 32339846
6,188 results