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Cigarette smoking, metabolic activation and carcinogenesis.
Nishikawa A, Mori Y, Lee IS, Tanaka T, Hirose M. Nishikawa A, et al. Among authors: tanaka t. Curr Drug Metab. 2004 Oct;5(5):363-73. doi: 10.2174/1389200043335441. Curr Drug Metab. 2004. PMID: 15544431 Review.
Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism.
Yoshida M, Katashima S, Ando J, Tanaka T, Uematsu F, Nakae D, Maekawa A. Yoshida M, et al. Among authors: tanaka t. Carcinogenesis. 2004 Nov;25(11):2257-64. doi: 10.1093/carcin/bgh225. Epub 2004 Jul 7. Carcinogenesis. 2004. PMID: 15240508
Potent chemopreventive agents against pancreatic cancer.
Nishikawa A, Furukawa F, Lee IS, Tanaka T, Hirose M. Nishikawa A, et al. Among authors: tanaka t. Curr Cancer Drug Targets. 2004 Jun;4(4):373-84. doi: 10.2174/1568009043332970. Curr Cancer Drug Targets. 2004. PMID: 15180502 Review.
Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cyclooxygenase-2 and inducible nitric oxide synthase.
Tanaka T, Suzuki R, Kohno H, Sugie S, Takahashi M, Wakabayashi K. Tanaka T, et al. Carcinogenesis. 2005 Jan;26(1):229-38. doi: 10.1093/carcin/bgh292. Epub 2004 Sep 30. Carcinogenesis. 2005. PMID: 15459021
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