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Characterization of SfmD as a Heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis.
Tang MC, Fu CY, Tang GL. Tang MC, et al. J Biol Chem. 2012 Feb 10;287(7):5112-21. doi: 10.1074/jbc.M111.306316. Epub 2011 Dec 20. J Biol Chem. 2012. PMID: 22187429 Free PMC article.
Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine.
Tang GL, Cheng YQ, Shen B. Tang GL, et al. J Biol Chem. 2007 Jul 13;282(28):20273-82. doi: 10.1074/jbc.M702814200. Epub 2007 May 14. J Biol Chem. 2007. PMID: 17502372
Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner.
Li L, Deng W, Song J, Ding W, Zhao QF, Peng C, Song WW, Tang GL, Liu W. Li L, et al. J Bacteriol. 2008 Jan;190(1):251-63. doi: 10.1128/JB.00826-07. Epub 2007 Nov 2. J Bacteriol. 2008. PMID: 17981978 Free PMC article.
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.
Fang J, Zhang Y, Huang L, Jia X, Zhang Q, Zhang X, Tang G, Liu W. Fang J, et al. J Bacteriol. 2008 Sep;190(17):6014-25. doi: 10.1128/JB.00533-08. Epub 2008 Jun 27. J Bacteriol. 2008. PMID: 18586939 Free PMC article.
Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis.
Zhao Q, He Q, Ding W, Tang M, Kang Q, Yu Y, Deng W, Zhang Q, Fang J, Tang G, Liu W. Zhao Q, et al. Chem Biol. 2008 Jul 21;15(7):693-705. doi: 10.1016/j.chembiol.2008.05.021. Chem Biol. 2008. PMID: 18635006
Dissection of two acyl-transfer reactions centered on acyl-S-carrier protein intermediates for incorporating 5-chloro-6-methyl-O-methylsalicyclic acid into chlorothricin.
He QL, Jia XY, Tang MC, Tian ZH, Tang GL, Liu W. He QL, et al. Chembiochem. 2009 Mar 23;10(5):813-9. doi: 10.1002/cbic.200800714. Chembiochem. 2009. PMID: 19266533 No abstract available.
Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework.
Yu Y, Duan L, Zhang Q, Liao R, Ding Y, Pan H, Wendt-Pienkowski E, Tang G, Shen B, Liu W. Yu Y, et al. ACS Chem Biol. 2009 Oct 16;4(10):855-64. doi: 10.1021/cb900133x. ACS Chem Biol. 2009. PMID: 19678698 Free PMC article.
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