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Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes.
Romanoski CE, Qi X, Sangam S, Vanderpool RR, Stearman RS, Conklin A, Gonzalez-Garay M, Rischard F, Ayon RJ, Wang J, Simonson T, Babicheva A, Shi Y, Tang H, Makino A, Kanthi Y, Geraci MW, Garcia JGN, Yuan JX, Desai AA. Romanoski CE, et al. Among authors: tang h. Pulm Circ. 2020 Dec 7;10(4):2045894020968531. doi: 10.1177/2045894020968531. eCollection 2020 Oct-Dec. Pulm Circ. 2020. PMID: 33343881 Free PMC article.
Functional characterization of voltage-dependent Ca(2+) channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS.
Ko EA, Wan J, Yamamura A, Zimnicka AM, Yamamura H, Yoo HY, Tang H, Smith KA, Sundivakkam PC, Zeifman A, Ayon RJ, Makino A, Yuan JX. Ko EA, et al. Among authors: tang h. Am J Physiol Cell Physiol. 2013 Jun 1;304(11):C1042-52. doi: 10.1152/ajpcell.00304.2012. Epub 2013 Feb 20. Am J Physiol Cell Physiol. 2013. PMID: 23426966 Free PMC article.
Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2.
Wan J, Yamamura A, Zimnicka AM, Voiriot G, Smith KA, Tang H, Ayon RJ, Choudhury MS, Ko EA, Wang J, Wang C, Makino A, Yuan JX. Wan J, et al. Among authors: tang h. Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15;305(2):L154-64. doi: 10.1152/ajplung.00313.2012. Epub 2013 May 17. Am J Physiol Lung Cell Mol Physiol. 2013. PMID: 23686856 Free PMC article.
Upregulated copper transporters in hypoxia-induced pulmonary hypertension.
Zimnicka AM, Tang H, Guo Q, Kuhr FK, Oh MJ, Wan J, Chen J, Smith KA, Fraidenburg DR, Choudhury MS, Levitan I, Machado RF, Kaplan JH, Yuan JX. Zimnicka AM, et al. Among authors: tang h. PLoS One. 2014 Mar 10;9(3):e90544. doi: 10.1371/journal.pone.0090544. eCollection 2014. PLoS One. 2014. PMID: 24614111 Free PMC article.
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Chen J, Tang H, Sysol JR, Moreno-Vinasco L, Shioura KM, Chen T, Gorshkova I, Wang L, Huang LS, Usatyuk PV, Sammani S, Zhou G, Raj JU, Garcia JG, Berdyshev E, Yuan JX, Natarajan V, Machado RF. Chen J, et al. Among authors: tang h. Am J Respir Crit Care Med. 2014 Nov 1;190(9):1032-43. doi: 10.1164/rccm.201401-0121OC. Am J Respir Crit Care Med. 2014. PMID: 25180446 Free PMC article.
Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension.
Tang H, Chen J, Fraidenburg DR, Song S, Sysol JR, Drennan AR, Offermanns S, Ye RD, Bonini MG, Minshall RD, Garcia JG, Machado RF, Makino A, Yuan JX. Tang H, et al. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L208-20. doi: 10.1152/ajplung.00242.2014. Epub 2014 Nov 21. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25416384 Free PMC article.
Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension.
Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX. Smith KA, et al. Among authors: tang h. Am J Respir Cell Mol Biol. 2015 Sep;53(3):355-67. doi: 10.1165/rcmb.2014-0235OC. Am J Respir Cell Mol Biol. 2015. PMID: 25569851 Free PMC article.
Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype.
Fernandez RA, Wan J, Song S, Smith KA, Gu Y, Tauseef M, Tang H, Makino A, Mehta D, Yuan JX. Fernandez RA, et al. Among authors: tang h. Am J Physiol Cell Physiol. 2015 Apr 15;308(8):C581-93. doi: 10.1152/ajpcell.00202.2014. Epub 2015 Feb 11. Am J Physiol Cell Physiol. 2015. PMID: 25673771 Free PMC article.
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