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Characterization of SfmD as a Heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis.
Tang MC, Fu CY, Tang GL. Tang MC, et al. J Biol Chem. 2012 Feb 10;287(7):5112-21. doi: 10.1074/jbc.M111.306316. Epub 2011 Dec 20. J Biol Chem. 2012. PMID: 22187429 Free PMC article.
Catalysis of Extracellular Deamination by a FAD-Linked Oxidoreductase after Prodrug Maturation in the Biosynthesis of Saframycin A.
Song LQ, Zhang YY, Pu JY, Tang MC, Peng C, Tang GL. Song LQ, et al. Angew Chem Int Ed Engl. 2017 Jul 24;56(31):9116-9120. doi: 10.1002/anie.201704726. Epub 2017 Jul 4. Angew Chem Int Ed Engl. 2017. PMID: 28561936
Biosynthesis of Tetrahydroisoquinoline Antibiotics.
Tang GL, Tang MC, Song LQ, Zhang Y. Tang GL, et al. Curr Top Med Chem. 2016;16(15):1717-26. doi: 10.2174/1568026616666151012112329. Curr Top Med Chem. 2016. PMID: 26456466 Review.
An unusual dehydratase acting on glycerate and a ketoreducatse stereoselectively reducing α-ketone in polyketide starter unit biosynthesis.
He HY, Yuan H, Tang MC, Tang GL. He HY, et al. Angew Chem Int Ed Engl. 2014 Oct 13;53(42):11315-9. doi: 10.1002/anie.201406602. Epub 2014 Aug 27. Angew Chem Int Ed Engl. 2014. PMID: 25160004
Unconventional origin and hybrid system for construction of pyrrolopyrrole moiety in kosinostatin biosynthesis.
Ma HM, Zhou Q, Tang YM, Zhang Z, Chen YS, He HY, Pan HX, Tang MC, Gao JF, Zhao SY, Igarashi Y, Tang GL. Ma HM, et al. Chem Biol. 2013 Jun 20;20(6):796-805. doi: 10.1016/j.chembiol.2013.04.013. Chem Biol. 2013. PMID: 23790490
Hijacking a hydroxyethyl unit from a central metabolic ketose into a nonribosomal peptide assembly line.
Peng C, Pu JY, Song LQ, Jian XH, Tang MC, Tang GL. Peng C, et al. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8540-5. doi: 10.1073/pnas.1204232109. Epub 2012 May 14. Proc Natl Acad Sci U S A. 2012. PMID: 22586110 Free PMC article.
Dissection of two acyl-transfer reactions centered on acyl-S-carrier protein intermediates for incorporating 5-chloro-6-methyl-O-methylsalicyclic acid into chlorothricin.
He QL, Jia XY, Tang MC, Tian ZH, Tang GL, Liu W. He QL, et al. Chembiochem. 2009 Mar 23;10(5):813-9. doi: 10.1002/cbic.200800714. Chembiochem. 2009. PMID: 19266533 No abstract available.
Cloning and elucidation of the FR901464 gene cluster revealing a complex acyltransferase-less polyketide synthase using glycerate as starter units.
Zhang F, He HY, Tang MC, Tang YM, Zhou Q, Tang GL. Zhang F, et al. J Am Chem Soc. 2011 Mar 2;133(8):2452-62. doi: 10.1021/ja105649g. Epub 2011 Feb 3. J Am Chem Soc. 2011. PMID: 21291275
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