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ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA.
Fujishiro SH, Tanimura S, Mure S, Kashimoto Y, Watanabe K, Kohno M. Fujishiro SH, et al. Among authors: tanimura s. Biochem Biophys Res Commun. 2008 Mar 28;368(1):162-7. doi: 10.1016/j.bbrc.2008.01.066. Epub 2008 Jan 22. Biochem Biophys Res Commun. 2008. PMID: 18211802
SH3P2 is a negative regulator of cell motility whose function is inhibited by ribosomal S6 kinase-mediated phosphorylation.
Tanimura S, Hashizume J, Kurosaki Y, Sei K, Gotoh A, Ohtake R, Kawano M, Watanabe K, Kohno M. Tanimura S, et al. Genes Cells. 2011 May;16(5):514-26. doi: 10.1111/j.1365-2443.2011.01503.x. Epub 2011 Apr 18. Genes Cells. 2011. PMID: 21501342
Histone deacetylase inhibitors enhance the chemosensitivity of tumor cells with cross-resistance to a wide range of DNA-damaging drugs.
Ozaki K, Kishikawa F, Tanaka M, Sakamoto T, Tanimura S, Kohno M. Ozaki K, et al. Among authors: tanimura s. Cancer Sci. 2008 Feb;99(2):376-84. doi: 10.1111/j.1349-7006.2007.00669.x. Epub 2008 Jan 15. Cancer Sci. 2008. PMID: 18201278
Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells.
Tanimura S, Hirano AI, Hashizume J, Yasunaga M, Kawabata T, Ozaki K, Kohno M. Tanimura S, et al. J Biol Chem. 2007 Dec 7;282(49):35430-9. doi: 10.1074/jbc.M707547200. Epub 2007 Sep 12. J Biol Chem. 2007. PMID: 17855353
Suppression of tumor cell invasiveness by hydrolyzable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/-9 activity.
Tanimura S, Kadomoto R, Tanaka T, Zhang YJ, Kouno I, Kohno M. Tanimura S, et al. Biochem Biophys Res Commun. 2005 May 20;330(4):1306-13. doi: 10.1016/j.bbrc.2005.03.116. Biochem Biophys Res Commun. 2005. PMID: 15823585
TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells.
Furuoka M, Ozaki K, Sadatomi D, Mamiya S, Yonezawa T, Tanimura S, Takeda K. Furuoka M, et al. Among authors: tanimura s. J Cell Physiol. 2016 Dec;231(12):2761-7. doi: 10.1002/jcp.25385. Epub 2016 Mar 30. J Cell Physiol. 2016. PMID: 26989816
Activation of protein phosphatase causes alternative splicing of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): potential effect on immune surveillance.
Kamachi M, Aramaki T, Tanimura S, Ichinose K, Fujikawa K, Iwamoto N, Yoshizaki A, Ida H, Kawakami A, Kohno M, Eguchi K. Kamachi M, et al. Among authors: tanimura s. Biochem Biophys Res Commun. 2007 Aug 17;360(1):280-5. doi: 10.1016/j.bbrc.2007.06.046. Epub 2007 Jun 15. Biochem Biophys Res Commun. 2007. PMID: 17583676
ERK signalling as a regulator of cell motility.
Tanimura S, Takeda K. Tanimura S, et al. J Biochem. 2017 Sep 1;162(3):145-154. doi: 10.1093/jb/mvx048. J Biochem. 2017. PMID: 28903547 Review.
GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability.
Kakiashvili E, Speight P, Waheed F, Seth R, Lodyga M, Tanimura S, Kohno M, Rotstein OD, Kapus A, Szászi K. Kakiashvili E, et al. Among authors: tanimura s. J Biol Chem. 2009 Apr 24;284(17):11454-66. doi: 10.1074/jbc.M805933200. Epub 2009 Mar 3. J Biol Chem. 2009. PMID: 19261619 Free PMC article.
Up-regulation of pro-apoptotic protein Bim and down-regulation of anti-apoptotic protein Mcl-1 cooperatively mediate enhanced tumor cell death induced by the combination of ERK kinase (MEK) inhibitor and microtubule inhibitor.
Kawabata T, Tanimura S, Asai K, Kawasaki R, Matsumaru Y, Kohno M. Kawabata T, et al. Among authors: tanimura s. J Biol Chem. 2012 Mar 23;287(13):10289-300. doi: 10.1074/jbc.M111.319426. Epub 2012 Jan 23. J Biol Chem. 2012. PMID: 22270368 Free PMC article.
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