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Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl)amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH.
Hasuda K, Lee C, Tannock IF. Hasuda K, et al. Among authors: tannock if. Oncol Res. 1994;6(6):259-68. Oncol Res. 1994. PMID: 7865901
Cell killing can be achieved in an acidic environment in tissue culture by nigericin, which acidifies cells by transporting H+ from the extracellular space into the cytoplasm; this cell killing can be enhanced when used with 5-(N-ethyl-N-isopropyl)amiloride (EIPA), a potent inhib …
Cell killing can be achieved in an acidic environment in tissue culture by nigericin, which acidifies cells by transporting H+ from the extr …
Tumor physiology and drug resistance.
Tannock IF. Tannock IF. Cancer Metastasis Rev. 2001;20(1-2):123-32. doi: 10.1023/a:1013125027697. Cancer Metastasis Rev. 2001. PMID: 11831640 Review.
493 results