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Epigenetic drug discovery: breaking through the immune barrier.
Tough DF, Tak PP, Tarakhovsky A, Prinjha RK. Tough DF, et al. Among authors: tarakhovsky a. Nat Rev Drug Discov. 2016 Dec;15(12):835-853. doi: 10.1038/nrd.2016.185. Epub 2016 Oct 21. Nat Rev Drug Discov. 2016. PMID: 27765940 Review.
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response.
Fang TC, Schaefer U, Mecklenbrauker I, Stienen A, Dewell S, Chen MS, Rioja I, Parravicini V, Prinjha RK, Chandwani R, MacDonald MR, Lee K, Rice CM, Tarakhovsky A. Fang TC, et al. Among authors: tarakhovsky a. J Exp Med. 2012 Apr 9;209(4):661-9. doi: 10.1084/jem.20112343. Epub 2012 Mar 12. J Exp Med. 2012. PMID: 22412156 Free PMC article.
Suppression of the antiviral response by an influenza histone mimic.
Marazzi I, Ho JS, Kim J, Manicassamy B, Dewell S, Albrecht RA, Seibert CW, Schaefer U, Jeffrey KL, Prinjha RK, Lee K, García-Sastre A, Roeder RG, Tarakhovsky A. Marazzi I, et al. Among authors: tarakhovsky a. Nature. 2012 Mar 14;483(7390):428-33. doi: 10.1038/nature10892. Nature. 2012. PMID: 22419161 Free PMC article.
Chromatin targeting drugs in cancer and immunity.
Prinjha R, Tarakhovsky A. Prinjha R, et al. Among authors: tarakhovsky a. Genes Dev. 2013 Aug 15;27(16):1731-8. doi: 10.1101/gad.221895.113. Genes Dev. 2013. PMID: 23964091 Free PMC article. Review.
The "histone mimicry" by pathogens.
Schaefer U, Ho JS, Prinjha RK, Tarakhovsky A. Schaefer U, et al. Among authors: tarakhovsky a. Cold Spring Harb Symp Quant Biol. 2013;78:81-90. doi: 10.1101/sqb.2013.78.020339. Epub 2014 Apr 14. Cold Spring Harb Symp Quant Biol. 2013. PMID: 24733380 Free PMC article.
Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice.
Sullivan JM, Badimon A, Schaefer U, Ayata P, Gray J, Chung CW, von Schimmelmann M, Zhang F, Garton N, Smithers N, Lewis H, Tarakhovsky A, Prinjha RK, Schaefer A. Sullivan JM, et al. Among authors: tarakhovsky a. J Exp Med. 2015 Oct 19;212(11):1771-81. doi: 10.1084/jem.20151271. Epub 2015 Sep 21. J Exp Med. 2015. PMID: 26392221 Free PMC article.
Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.
Yoshida H, Bansal K, Schaefer U, Chapman T, Rioja I, Proekt I, Anderson MS, Prinjha RK, Tarakhovsky A, Benoist C, Mathis D. Yoshida H, et al. Among authors: tarakhovsky a. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4448-57. doi: 10.1073/pnas.1512081112. Epub 2015 Jul 27. Proc Natl Acad Sci U S A. 2015. PMID: 26216992 Free PMC article.
Influenza virus infection causes global RNAPII termination defects.
Zhao N, Sebastiano V, Moshkina N, Mena N, Hultquist J, Jimenez-Morales D, Ma Y, Rialdi A, Albrecht R, Fenouil R, Sánchez-Aparicio MT, Ayllon J, Ravisankar S, Haddad B, Ho JSY, Low D, Jin J, Yurchenko V, Prinjha RK, Tarakhovsky A, Squatrito M, Pinto D, Allette K, Byun M, Smith ML, Sebra R, Guccione E, Tumpey T, Krogan N, Greenbaum B, van Bakel H, García-Sastre A, Marazzi I. Zhao N, et al. Among authors: tarakhovsky a. Nat Struct Mol Biol. 2018 Sep;25(9):885-893. doi: 10.1038/s41594-018-0124-7. Epub 2018 Sep 3. Nat Struct Mol Biol. 2018. PMID: 30177761 Free PMC article.
103 results