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The increased synthesis of inducible nitric oxide inhibits IL-1ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation.
Pelletier JP, Mineau F, Ranger P, Tardif G, Martel-Pelletier J. Pelletier JP, et al. Among authors: tardif g. Osteoarthritis Cartilage. 1996 Mar;4(1):77-84. doi: 10.1016/s1063-4584(96)80009-4. Osteoarthritis Cartilage. 1996. PMID: 8731398
Treatment with 200 microM N(g)-monomethyl-L-arginine (L-NMA), a well known NO synthase inhibitor, induced over 70% inhibition of the NO production and a marked increased IL-1ra synthesis (average of 84%) and expression (mRNA level). ...
Treatment with 200 microM N(g)-monomethyl-L-arginine (L-NMA), a well known NO synthase inhibitor, induced over 70% inhibition of the …
Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation. Possible role of IGF-1-binding proteins.
Doré S, Pelletier JP, DiBattista JA, Tardif G, Brazeau P, Martel-Pelletier J. Doré S, et al. Among authors: tardif g. Arthritis Rheum. 1994 Feb;37(2):253-63. doi: 10.1002/art.1780370215. Arthritis Rheum. 1994. PMID: 7510486
Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor.
Sadouk MB, Pelletier JP, Tardif G, Kiansa K, Cloutier JM, Martel-Pelletier J. Sadouk MB, et al. Among authors: tardif g. Lab Invest. 1995 Sep;73(3):347-55. Lab Invest. 1995. PMID: 7564267
Effects of tenidap on canine experimental osteoarthritis. I. Morphologic and metalloprotease analysis.
Fernandes JC, Martel-Pelletier J, Otterness IG, Lopez-Anaya A, Mineau F, Tardif G, Pelletier JP. Fernandes JC, et al. Among authors: tardif g. Arthritis Rheum. 1995 Sep;38(9):1290-303. doi: 10.1002/art.1780380918. Arthritis Rheum. 1995. PMID: 7575725
Increased insulin-like growth factor 1 production by human osteoarthritic chondrocytes is not dependent on growth hormone action.
Doré S, Abribat T, Rousseau N, Brazeau P, Tardif G, DiBattista JA, Cloutier JM, Pelletier JP, Martel-Pelletier J. Doré S, et al. Among authors: tardif g. Arthritis Rheum. 1995 Mar;38(3):413-9. doi: 10.1002/art.1780380319. Arthritis Rheum. 1995. PMID: 7880196
Reduced expression of glucocorticoid receptor levels in human osteoarthritic chondrocytes. Role in the suppression of metalloprotease synthesis.
DiBattista JA, Martel-Pelletier J, Antakly T, Tardif G, Cloutier JM, Pelletier JP. DiBattista JA, et al. Among authors: tardif g. J Clin Endocrinol Metab. 1993 May;76(5):1128-34. doi: 10.1210/jcem.76.5.8496302. J Clin Endocrinol Metab. 1993. PMID: 8496302
The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis.
Reboul P, Pelletier JP, Tardif G, Cloutier JM, Martel-Pelletier J. Reboul P, et al. Among authors: tardif g. J Clin Invest. 1996 May 1;97(9):2011-9. doi: 10.1172/JCI118636. J Clin Invest. 1996. PMID: 8621789 Free PMC article.
Normal expression of type 1 insulin-like growth factor receptor by human osteoarthritic chondrocytes with increased expression and synthesis of insulin-like growth factor binding proteins.
Tardif G, Reboul P, Pelletier JP, Geng C, Cloutier JM, Martel-Pelletier J. Tardif G, et al. Arthritis Rheum. 1996 Jun;39(6):968-78. doi: 10.1002/art.1780390614. Arthritis Rheum. 1996. PMID: 8651991
Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression.
Caron JP, Fernandes JC, Martel-Pelletier J, Tardif G, Mineau F, Geng C, Pelletier JP. Caron JP, et al. Among authors: tardif g. Arthritis Rheum. 1996 Sep;39(9):1535-44. doi: 10.1002/art.1780390914. Arthritis Rheum. 1996. PMID: 8814066
In vitro effects of 2 antirheumatic drugs on the synthesis and expression of proinflammatory cytokines in synovial membranes from patients with rheumatoid arthritis.
Ounissi-Benkalha H, Pelletier JP, Tardif G, Mineau F, Jolicoeur FC, Ranger P, Martel-Pelletier J. Ounissi-Benkalha H, et al. Among authors: tardif g. J Rheumatol. 1996 Jan;23(1):16-23. J Rheumatol. 1996. PMID: 8838503
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