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Targeted Genotyping in Clinical Pharmacogenomics: What Is Missing?
Lopes JL, Harris K, Karow MB, Peterson SE, Kluge ML, Kotzer KE, Lopes GS, Larson NB, Bielinski SJ, Scherer SE, Wang L, Weinshilboum RM, Black JL 3rd, Moyer AM. Lopes JL, et al. J Mol Diagn. 2022 Mar;24(3):253-261. doi: 10.1016/j.jmoldx.2021.11.008. Epub 2022 Jan 15. J Mol Diagn. 2022. PMID: 35041929 Free PMC article.
Clinical pharmacogenomic testing typically uses targeted genotyping, which only detects variants included in the test design and may vary among laboratories. ...The results of in silico targeted genotyping were compared with the clinic …
Clinical pharmacogenomic testing typically uses targeted genotyping, which only detects variants included in the …
Validating the pharmacogenomics of chemotherapy-induced cardiotoxicity: What is missing?
Magdy T, Burmeister BT, Burridge PW. Magdy T, et al. Pharmacol Ther. 2016 Dec;168:113-125. doi: 10.1016/j.pharmthera.2016.09.009. Epub 2016 Sep 5. Pharmacol Ther. 2016. PMID: 27609196 Free PMC article. Review.
The effect of chemotherapeutic regimes on the heart largely involves cardiomyocyte death, leading to cardiomyopathy and heart failure, or the induction of arrhythmias. Of these cardiotoxic drugs, those resulting in clinical cardiotoxicity can range from 8 to 26% for doxoru …
The effect of chemotherapeutic regimes on the heart largely involves cardiomyocyte death, leading to cardiomyopathy and heart failure, or th …
Genetics of rheumatoid arthritis: time for a change!
de Vries R. de Vries R. Curr Opin Rheumatol. 2011 May;23(3):227-32. doi: 10.1097/BOR.0b013e3283457524. Curr Opin Rheumatol. 2011. PMID: 21427575 Review.
PURPOSE OF REVIEW: To review recent progress in the genetics of rheumatoid arthritis (RA) and discuss the implications for understanding the pathogenesis of the disease as well as clinical application. RECENT FINDINGS: Protection against anticitrullinated protein antibody …
PURPOSE OF REVIEW: To review recent progress in the genetics of rheumatoid arthritis (RA) and discuss the implications for understanding the …
Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility.
Ye BD, McGovern DP. Ye BD, et al. Expert Rev Clin Immunol. 2016 Oct;12(10):1091-107. doi: 10.1080/1744666X.2016.1184972. Epub 2016 Jun 15. Expert Rev Clin Immunol. 2016. PMID: 27156530 Free PMC article. Review.
Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations of linkage analysis, multiple genome-wide association studies, their meta-analyses, and …
Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory bowel disease (IBD) is strongly influenced …
Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma.
Dighe SG, Chen J, Yan L, He Q, Gharahkhani P, Onstad L, Levine DM, Palles C, Ye W, Gammon MD, Iyer PG, Anderson LA, Liu G, Wu AH, Dai JY, Chow WH, Risch HA, Lagergren J, Shaheen NJ, Bernstein L, Corley DA, Prenen H, deCaestecker J, MacDonald D, Moayyedi P, Barr H, Love SB, Chegwidden L, Attwood S, Watson P, Harrison R, Ott K, Moebus S, Venerito M, Lang H, Mayershofer R, Knapp M, Veits L, Gerges C, Weismüller J, Gockel I, Vashist Y, Nöthen MM, Izbicki JR, Manner H, Neuhaus H, Rösch T, Böhmer AC, Hölscher AH, Anders M, Pech O, Schumacher B, Schmidt C, Schmidt T, Noder T, Lorenz D, Vieth M, May A, Hess T, Kreuser N, Becker J, Ell C, Ambrosone CB, Moysich KB, MacGregor S, Tomlinson I, Whiteman DC, Jankowski J, Schumacher J, Vaughan TL, Madeleine MM, Hardie LJ, Buas MF. Dighe SG, et al. Carcinogenesis. 2021 Apr 17;42(3):369-377. doi: 10.1093/carcin/bgaa132. Carcinogenesis. 2021. PMID: 33300568 Free PMC article.
Targeted assessment of genetic variation in biologically relevant pathways using novel analytical approaches may identify missed susceptibility signals. ...Principal component analysis was employed to evaluate pathway-level and gene-level associations with BE/EAC, u …
Targeted assessment of genetic variation in biologically relevant pathways using novel analytical approaches may identify missed …