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Targeting Tie2 for Treatment of Diabetic Retinopathy and Diabetic Macular Edema.
Campochiaro PA, Peters KG. Campochiaro PA, et al. Curr Diab Rep. 2016 Dec;16(12):126. doi: 10.1007/s11892-016-0816-5. Curr Diab Rep. 2016. PMID: 27778249 Review.
Activated Tie2 increases endothelial cell survival, adhesion, and cell junction integrity, thereby stabilizing the vasculature. ...These data suggest that Tie2 activation may be a valuable strategy to treat or prevent diabetic retinopathy
Activated Tie2 increases endothelial cell survival, adhesion, and cell junction integrity, thereby stabilizing the v
Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature.
Shen J, Frye M, Lee BL, Reinardy JL, McClung JM, Ding K, Kojima M, Xia H, Seidel C, Lima e Silva R, Dong A, Hackett SF, Wang J, Howard BW, Vestweber D, Kontos CD, Peters KG, Campochiaro PA. Shen J, et al. J Clin Invest. 2014 Oct;124(10):4564-76. doi: 10.1172/JCI74527. Epub 2014 Sep 2. J Clin Invest. 2014. PMID: 25180601 Free PMC article.
Intraocular injection of an anti-VE-PTP antibody previously shown to activate TIE2 suppressed ocular NV. Furthermore, a small-molecule inhibitor of VE-PTP catalytic activity (AKB-9778) activated TIE2, enhanced ANG1-induced TIE2
Intraocular injection of an anti-VE-PTP antibody previously shown to activate TIE2 suppressed ocular NV. Furthermore, a …
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