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Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain.
Li Z, Tseng PY, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z, Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet JH, Geng Y, Xiao B, Peng J, Hopkins C, Raja SN, Guan Y, Dong X. Li Z, et al. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1996-E2005. doi: 10.1073/pnas.1615255114. Epub 2017 Feb 21. Proc Natl Acad Sci U S A. 2017. PMID: 28223516 Free PMC article.
Human Mas-related G protein-coupled receptor X1 (MRGPRX1) is a promising target for pain inhibition, mainly because of its restricted expression in nociceptors within the peripheral nervous system. ...Ou …
Human Mas-related G protein-coupled receptor X1 (MRGPRX1) is a promising target …
Ligand recognition and allosteric modulation of the human MRGPRX1 receptor.
Liu Y, Cao C, Huang XP, Gumpper RH, Rachman MM, Shih SL, Krumm BE, Zhang S, Shoichet BK, Fay JF, Roth BL. Liu Y, et al. Nat Chem Biol. 2023 Apr;19(4):416-422. doi: 10.1038/s41589-022-01173-6. Epub 2022 Oct 27. Nat Chem Biol. 2023. PMID: 36302898
The human MAS-related G protein-coupled receptor X1 (MRGPRX1) is preferentially expressed in the small-diameter primary sensory neurons and involved in the mediation of nociception and pruritus. Central activation of MRGPRX1 …
The human MAS-related G protein-coupled receptor X1 (MRGPRX1) is preferentially expr …
Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch.
Duran P, Retamal JS, de Amorim Ferreira M, Trevett K, Jensen DD. Duran P, et al. bioRxiv [Preprint]. 2025 Nov 13:2025.11.12.688053. doi: 10.1101/2025.11.12.688053. bioRxiv. 2025. PMID: 41292893 Free PMC article. Preprint.
G protein-coupled receptors (GPCRs) and TRPV (transient receptor potential vanilloid) channels are crucial for signal transduction in physiological processes, including neurotransmission, pain, and itch. ...Recent evidence suggests GPCRs continu …
G protein-coupled receptors (GPCRs) and TRPV (transient receptor potential vanilloid) channels are crucial for s …