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Targeting proline in (phospho)proteomics.
van der Laarse SAM, van Gelder CAGH, Bern M, Akeroyd M, Olsthoorn MMA, Heck AJR. van der Laarse SAM, et al. FEBS J. 2020 Jul;287(14):2979-2997. doi: 10.1111/febs.15190. Epub 2020 Jan 13. FEBS J. 2020. PMID: 31863553 Free PMC article.
To tackle this problem, alternative proteases have been introduced and shown to lead to an increase in the detectable (phospho)proteome. Here, we argue that there may be further room for improvement and explore the protease EndoPro. ...EndoPro extends the coverable …
To tackle this problem, alternative proteases have been introduced and shown to lead to an increase in the detectable (phospho)pro
PIM1 kinase promotes gallbladder cancer cell proliferation via inhibition of proline-rich Akt substrate of 40 kDa (PRAS40).
Subbannayya T, Leal-Rojas P, Zhavoronkov A, Ozerov IV, Korzinkin M, Babu N, Radhakrishnan A, Chavan S, Raja R, Pinto SM, Patil AH, Barbhuiya MA, Kumar P, Guerrero-Preston R, Navani S, Tiwari PK, Kumar RV, Prasad TSK, Roa JC, Pandey A, Sidransky D, Gowda H, Izumchenko E, Chatterjee A. Subbannayya T, et al. J Cell Commun Signal. 2019 Jun;13(2):163-177. doi: 10.1007/s12079-018-00503-5. Epub 2019 Jan 21. J Cell Commun Signal. 2019. PMID: 30666556 Free PMC article.
Proline-rich Akt substrate 40 kDa (PRAS40) was one of the proteins found to be hyperphosphorylated in all the invasive GBC cell lines. ...Our results support the role of PRAS40 phosphorylation in GBC cell survival and aggressiveness. This study also elucidates phospho
Proline-rich Akt substrate 40 kDa (PRAS40) was one of the proteins found to be hyperphosphorylated in all the invasive GBC cell lines
The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation.
Uddin B, Partscht P, Chen NP, Neuner A, Weiß M, Hardt R, Jafarpour A, Heßling B, Ruppert T, Lorenz H, Pereira G, Schiebel E. Uddin B, et al. EMBO Rep. 2019 Jan;20(1):e46544. doi: 10.15252/embr.201846544. Epub 2018 Nov 22. EMBO Rep. 2019. PMID: 30467237 Free PMC article.
CDC14A codes for a conserved proline-directed phosphatase, and mutations in the gene are associated with autosomal-recessive severe to profound deafness, due to defective kinocilia. ...Here, we show that human RPE1 hCDC14A(PD) cells, encoding a phosphatase dead version of …
CDC14A codes for a conserved proline-directed phosphatase, and mutations in the gene are associated with autosomal-recessive severe t …
Early targets of lithium in rat kidney inner medullary collecting duct include p38 and ERK1/2.
Trepiccione F, Pisitkun T, Hoffert JD, Poulsen SB, Capasso G, Nielsen S, Knepper MA, Fenton RA, Christensen BM. Trepiccione F, et al. Kidney Int. 2014 Oct;86(4):757-67. doi: 10.1038/ki.2014.107. Epub 2014 Apr 30. Kidney Int. 2014. PMID: 24786704 Free article.
The majority of the upregulated phosphopeptides contained a proline-directed motif, a known target of MAPK. Four hours after lithium exposure, phosphorylation sites in the activation loops of ERK1/2 and p38 were upregulated. Increased expression of phospho-Se …
The majority of the upregulated phosphopeptides contained a proline-directed motif, a known target of MAPK. Four hours after l …
The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia.
Di Conza G, Trusso Cafarello S, Loroch S, Mennerich D, Deschoemaeker S, Di Matteo M, Ehling M, Gevaert K, Prenen H, Zahedi RP, Sickmann A, Kietzmann T, Moretti F, Mazzone M. Di Conza G, et al. Cell Rep. 2017 Feb 14;18(7):1699-1712. doi: 10.1016/j.celrep.2017.01.051. Cell Rep. 2017. PMID: 28199842 Free PMC article.
Here, we show that PHD2 is phosphorylated on serine 125 (S125) by the mechanistic target of rapamycin (mTOR) downstream kinase P70S6K and that this phosphorylation increases its ability to degrade HIF1alpha. mTOR blockade in hypoxia by REDD1 restrains P70S6K and unleashes …
Here, we show that PHD2 is phosphorylated on serine 125 (S125) by the mechanistic target of rapamycin (mTOR) downstream kinase P70S6K …
Global analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitro.
Mendoza J, Sekiya M, Taniguchi T, Iijima KM, Wang R, Ando K. Mendoza J, et al. J Proteome Res. 2013 Jun 7;12(6):2654-65. doi: 10.1021/pr400008f. Epub 2013 Apr 26. J Proteome Res. 2013. PMID: 23550703 Free PMC article.
Using recombinant human tau phosphorylated by Chk1 and Chk2 in vitro, we first analyzed tau phosphorylation at the AD-related sites by Western blot with phospho-tau-specific antibodies. Second, to globally identify phosphorylated sites in tau, liquid chromatography-tandem …
Using recombinant human tau phosphorylated by Chk1 and Chk2 in vitro, we first analyzed tau phosphorylation at the AD-related sites by Weste …
Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis.
Grant NJ, Coates PJ, Woods YL, Bray SE, Morrice NA, Hastie CJ, Lamont DJ, Carey FA, Sutherland C. Grant NJ, et al. BMC Cancer. 2015 Nov 10;15:885. doi: 10.1186/s12885-015-1691-1. BMC Cancer. 2015. PMID: 26555036 Free PMC article.
METHODS: Here we use in vitro and in cell phosphorylation assays to identify novel features of CDK5 target sequence determinants that confer enhanced CDK5 selectivity, providing means to select substrate biomarkers of CDK5 activity with more confidence. ...In contrast the …
METHODS: Here we use in vitro and in cell phosphorylation assays to identify novel features of CDK5 target sequence determinants that …
Quantitative phosphoproteomic analysis reveals cAMP/vasopressin-dependent signaling pathways in native renal thick ascending limb cells.
Gunaratne R, Braucht DW, Rinschen MM, Chou CL, Hoffert JD, Pisitkun T, Knepper MA. Gunaratne R, et al. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15653-8. doi: 10.1073/pnas.1007424107. Epub 2010 Aug 16. Proc Natl Acad Sci U S A. 2010. PMID: 20713729 Free PMC article.
The population of up-regulated phosphopeptides was highly enriched in basophilic kinase substrate motifs (AGC or calmodulin-sensitive kinase families), whereas the down-regulated sites were dominated by "proline-directed" motifs (cyclin-dependent or MAP kinase families). . …
The population of up-regulated phosphopeptides was highly enriched in basophilic kinase substrate motifs (AGC or calmodulin-sensitive kinase …
Novel Ser/Thr protein phosphatase 5 (PP5) regulated targets during DNA damage identified by proteomics analysis.
Ham BM, Jayachandran H, Yang F, Jaitly N, Polpitiya AD, Monroe ME, Wang L, Zhao R, Purvine SO, Livesay EA, Camp DG 2nd, Rossie S, Smith RD. Ham BM, et al. J Proteome Res. 2010 Feb 5;9(2):945-53. doi: 10.1021/pr9008207. J Proteome Res. 2010. PMID: 20039704 Free PMC article.
Biological replicate analyses of bleomycin-treated HeLa cells expressing either WT-PP5 or mutant inactive PP5 lead to the identification of six potential target proteins of PP5 action. Four of these putative targets have been previously reported to be involved in DN …
Biological replicate analyses of bleomycin-treated HeLa cells expressing either WT-PP5 or mutant inactive PP5 lead to the identification of …
Combining peptide recognition specificity and context information for the prediction of the 14-3-3-mediated interactome in S. cerevisiae and H. sapiens.
Panni S, Montecchi-Palazzi L, Kiemer L, Cabibbo A, Paoluzi S, Santonico E, Landgraf C, Volkmer-Engert R, Bachi A, Castagnoli L, Cesareni G. Panni S, et al. Proteomics. 2011 Jan;11(1):128-43. doi: 10.1002/pmic.201000030. Epub 2010 Dec 6. Proteomics. 2011. PMID: 21182200
We have first characterized the recognition specificity of this domain family, largely confirming the results of previous analyses, while revealing new features of the preferred sequence context of 14-3-3 phospho-peptide partners. Notably, a proline next to the carb …
We have first characterized the recognition specificity of this domain family, largely confirming the results of previous analyses, while re …