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Targeting the PI3K/AKT/mTOR Pathway in Bladder Cancer.
Sathe A, Nawroth R. Sathe A, et al. Methods Mol Biol. 2018;1655:335-350. doi: 10.1007/978-1-4939-7234-0_23. Methods Mol Biol. 2018. PMID: 28889395 Review.
The PI3K/AKT/mTOR signaling pathway shows frequent molecular alterations and increased activity in cancer. Given its role in the regulation of cell growth, survival and metastasis, molecules within this pathway are promising targets …
The PI3K/AKT/mTOR signaling pathway shows frequent molecular alterations and increased activity in cancer …
Gypenoside-Induced Apoptosis via the PI3K/AKT/mTOR Signaling Pathway in Bladder Cancer.
Li X, Liu H, Lv C, Du J, Lian F, Zhang S, Wang Z, Zeng Y. Li X, et al. Biomed Res Int. 2022 Mar 29;2022:9304552. doi: 10.1155/2022/9304552. eCollection 2022. Biomed Res Int. 2022. PMID: 35402614 Free PMC article.

As expected, gypenosides displayed apoptosis-inducing properties in bladder cancer cells by inactivating the PI3K/AKT/mTOR signaling pathway in vitro. Furthermore, gypenosides significantly (P < 0.05) inhibited the growth of bladder

…
As expected, gypenosides displayed apoptosis-inducing properties in bladder cancer cells by inactivating the PI3K/AK …
Metabolic phenotype of bladder cancer.
Massari F, Ciccarese C, Santoni M, Iacovelli R, Mazzucchelli R, Piva F, Scarpelli M, Berardi R, Tortora G, Lopez-Beltran A, Cheng L, Montironi R. Massari F, et al. Cancer Treat Rev. 2016 Apr;45:46-57. doi: 10.1016/j.ctrv.2016.03.005. Epub 2016 Mar 8. Cancer Treat Rev. 2016. PMID: 26975021 Free article. Review.
Metabolism of bladder cancer represents a key issue for cancer research. Several metabolic altered pathways are involved in bladder tumorigenesis, representing therefore interesting targets for therapy. ...Moreover, the PTEN/PI3K/ …
Metabolism of bladder cancer represents a key issue for cancer research. Several metabolic altered pathways are …
Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway.
Ching CB, Hansel DE. Ching CB, et al. Lab Invest. 2010 Oct;90(10):1406-14. doi: 10.1038/labinvest.2010.133. Epub 2010 Jul 26. Lab Invest. 2010. PMID: 20661228 Free article. Review.
To address the role of mTOR pathway activity in UCC, we will first review the basic elements of the PI3K/Akt/mTOR pathway and then apply this pathway to bladder cancer oncogenesis. As will be evident, significant progress ha …
To address the role of mTOR pathway activity in UCC, we will first review the basic elements of the PI3K/Akt/mTOR …
DHCR7 promotes tumorigenesis via activating PI3K/AKT/mTOR signalling pathway in bladder cancer.
Li Y, Zhou Y, Huang M, Wang Z, Liu D, Liu J, Fu X, Yang S, Shan S, Yang L, Guo Y, Ren P, Chen P, Zeng G, Guo Y, Wang X, DiSanto ME, Zhang X. Li Y, et al. Cell Signal. 2023 Feb;102:110553. doi: 10.1016/j.cellsig.2022.110553. Epub 2022 Dec 5. Cell Signal. 2023. PMID: 36473621
We further demonstrated that DHCR7 overexpression could accelerate the G0/G1 phase to accelerate the growth of tumor cells, antagonize cell apoptosis, and enhance the invasion and migration capacity, as well as EMT process via PI3K/AKT/mTOR signalling path …
We further demonstrated that DHCR7 overexpression could accelerate the G0/G1 phase to accelerate the growth of tumor cells, antagonize cell …
Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential use in the treatment of bladder cancers.
Houédé N, Pourquier P. Houédé N, et al. Pharmacol Ther. 2015 Jan;145:1-18. doi: 10.1016/j.pharmthera.2014.06.004. Epub 2014 Jun 12. Pharmacol Ther. 2015. PMID: 24929024 Free article. Review.
This is especially the case for mutations of genes involved in the PI3K/AKT/mTOR signaling pathway that occupies a major place in the etiology of these tumors. Here, we describe the mutations leading to constitutive activation of the PI3K/AKT …
This is especially the case for mutations of genes involved in the PI3K/AKT/mTOR signaling pathway that occupies …
STIL Promotes Tumorigenesis of Bladder Cancer by Activating PI3K/AKT/mTOR Signaling Pathway and Targeting C-Myc.
Yu H, Chen L, Wang X, Tang F, Wan Z, Wang H, Fu Q, Chen Z, Shi J, Hu X, Zuhaer Y, Aersi M, Liu T, Tao H, Peng J. Yu H, et al. Cancers (Basel). 2022 Nov 24;14(23):5777. doi: 10.3390/cancers14235777. Cancers (Basel). 2022. PMID: 36497260 Free PMC article.
Moreover, cell cycle arrest in the G0/G1 phase was triggered by decreasing STIL, which led to delayed BC cell growth in vitro and in vivo. Mechanically, STIL knockout inhibited the PI3K/AKT/mTOR pathway and down-regulated the expression of c-myc. Furth …
Moreover, cell cycle arrest in the G0/G1 phase was triggered by decreasing STIL, which led to delayed BC cell growth in vitro and in vivo. M …
RAC3 Inhibition Induces Autophagy to Impair Metastasis in Bladder Cancer Cells via the PI3K/AKT/mTOR Pathway.
Wang L, Shi J, Liu S, Huang Y, Ding H, Zhao B, Liu Y, Wang W, Yang J, Chen Z. Wang L, et al. Front Oncol. 2022 Jun 30;12:915240. doi: 10.3389/fonc.2022.915240. eCollection 2022. Front Oncol. 2022. PMID: 35847878 Free PMC article.
BACKGROUND: Bladder cancer (BCa) is one of the most frequent malignant tumors globally, with a significant morbidity and mortality rate. ...In vitro and in vivo proliferation, migration, autophagy, and other phenotypic changes were examined by constructing knockdown …
BACKGROUND: Bladder cancer (BCa) is one of the most frequent malignant tumors globally, with a significant morbidity and morta …
Targeting the PI3K signaling pathway in cancer therapy.
Bartholomeusz C, Gonzalez-Angulo AM. Bartholomeusz C, et al. Expert Opin Ther Targets. 2012 Jan;16(1):121-30. doi: 10.1517/14728222.2011.644788. Epub 2012 Jan 12. Expert Opin Ther Targets. 2012. PMID: 22239433 Review.
Targetable genetic aberrations in this pathway give us many opportunities for development of targeted therapies for different types of cancer. ...EXPERT OPINION: Small-molecule inhibitors targeting the PI3K/Akt/mTOR pathw …
Targetable genetic aberrations in this pathway give us many opportunities for development of targeted therapies for dif …
Ginsenoside Rg1 Suppresses Non-Small-Cell Lung Cancer via MicroRNA-126-PI3K-AKT-mTOR Pathway.
Chen P, Li X, Yu X, Yang M. Chen P, et al. Evid Based Complement Alternat Med. 2022 Jul 1;2022:1244836. doi: 10.1155/2022/1244836. eCollection 2022. Evid Based Complement Alternat Med. 2022. PMID: 35815288 Free PMC article. Retracted.
Interesting, in silico analysis indicated that miR-126 could target PI3K signaling pathway, which was confirmed by WB assay. KD of PI3KR2 compromised promotion of miR-126 on cell apoptosis. Similarly, it was found that KD of mTOR compromised promotion of miR-126 on …
Interesting, in silico analysis indicated that miR-126 could target PI3K signaling pathway, which was confirmed by WB assay. K …
70 results