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Use of anti-thymocyte globulin in the management of refractory systemic autoimmune diseases.
Tarkowski A, Andersson-Gäre B, Aurell M. Tarkowski A, et al. Scand J Rheumatol. 1993;22(6):261-6. doi: 10.3109/03009749309095136. Scand J Rheumatol. 1993. PMID: 8266027
Administration of polyclonal anti-T-cell antibodies was performed at a single occasion via a central venous catheter during 9-10 days. ...
Administration of polyclonal anti-T-cell antibodies was performed at a single occasion via a central venous catheter during 9- …
Polymorphism in promoter region of IL10 gene is associated with rheumatoid arthritis in women.
Padyukov L, Hytönen AM, Smolnikova M, Hahn-Zoric M, Nilsson N, Hanson LA, Tarkowski A, Klareskog L. Padyukov L, et al. Among authors: tarkowski a. J Rheumatol. 2004 Mar;31(3):422-5. J Rheumatol. 2004. PMID: 14994383
OBJECTIVE: Rheumatoid arthritis (RA) is a genetically complex disease with many possible phenotypes. We investigated IL10 and TNFA gene polymorphisms in a group of Swedish women and men with RA compared with healthy individuals to estimate combinations of alleles sp …
OBJECTIVE: Rheumatoid arthritis (RA) is a genetically complex disease with many possible phenotypes. We investigated IL10 and TNFA ge …
Cerebral inflammation and degeneration in systemic lupus erythematosus.
Trysberg E, Tarkowski A. Trysberg E, et al. Among authors: tarkowski a. Curr Opin Rheumatol. 2004 Sep;16(5):527-33. doi: 10.1097/01.bor.0000135451.85671.14. Curr Opin Rheumatol. 2004. PMID: 15314489 Review.
Longterm clinical and immunological effects of anti-CD20 treatment in patients with refractory systemic lupus erythematosus.
Lindholm C, Börjesson-Asp K, Zendjanchi K, Sundqvist AC, Tarkowski A, Bokarewa M. Lindholm C, et al. Among authors: tarkowski a. J Rheumatol. 2008 May;35(5):826-33. Epub 2008 Apr 1. J Rheumatol. 2008. PMID: 18398943
The responders were characterized by having shorter nephritis duration, a baseline GFR > 30 ml/min, and detectable circulating CD19+ B lymphocytes before B cell depletion. Anti-CD20 treatment was highly effective in patients with autoimmune thrombocytopenia, inducing …
The responders were characterized by having shorter nephritis duration, a baseline GFR > 30 ml/min, and detectable circulating CD1 …
Intraarticular release and accumulation of defensins and bactericidal/permeability-increasing protein in patients with rheumatoid arthritis.
Bokarewa MI, Jin T, Tarkowski A. Bokarewa MI, et al. Among authors: tarkowski a. J Rheumatol. 2003 Aug;30(8):1719-24. J Rheumatol. 2003. PMID: 12913926
We assessed concentrations of BPI and a-defensins in synovial fluid (SF) and matching blood samples of patients with rheumatoid arthritis (RA). ...Blood samples from 22 healthy individuals made up a control group. Concentrations of BPI and human neutrophil peptides …
We assessed concentrations of BPI and a-defensins in synovial fluid (SF) and matching blood samples of patients with rheumatoid arthr …
Salivary resistin reflects local inflammation in Sjögren's syndrome.
Boström EA, d'Elia HF, Dahlgren U, Simark-Mattsson C, Hasséus B, Carlsten H, Tarkowski A, Bokarewa M. Boström EA, et al. Among authors: tarkowski a. J Rheumatol. 2008 Oct;35(10):2005-11. Epub 2008 Aug 15. J Rheumatol. 2008. PMID: 18709689 Clinical Trial.
We suggest that resistin is expressed in the salivary glands of patients with pSS and may be a driving factor of local inflammation....
We suggest that resistin is expressed in the salivary glands of patients with pSS and may be a driving factor of local inflammation.. …
Intrathecal levels of matrix metalloproteinases in systemic lupus erythematosus with central nervous system engagement.
Trysberg E, Blennow K, Zachrisson O, Tarkowski A. Trysberg E, et al. Among authors: tarkowski a. Arthritis Res Ther. 2004;6(6):R551-6. doi: 10.1186/ar1228. Epub 2004 Sep 23. Arthritis Res Ther. 2004. PMID: 15535833 Free PMC article.
The matrix metalloproteinases (MMPs) are a group of tissue degrading enzymes that may be involved in this ongoing brain destruction. ...A total of 123 patients with SLE were evaluated clinically, with magnetic resonance imaging of brain and cerebrospinal fluid (CSF) …
The matrix metalloproteinases (MMPs) are a group of tissue degrading enzymes that may be involved in this ongoing brain destruction. …
Urokinase, a constitutive component of the inflamed synovial fluid, induces arthritis.
Jin T, Tarkowski A, Carmeliet P, Bokarewa M. Jin T, et al. Among authors: tarkowski a. Arthritis Res Ther. 2003;5(1):R9-R17. doi: 10.1186/ar606. Epub 2002 Oct 17. Arthritis Res Ther. 2003. PMID: 12716448 Free PMC article.
Accumulation of uPA locally in the joint cavity is a typical finding in erosive RA. uPA exerts potent arthritogenic properties and thus may be viewed as one of the essential mediators of joint inflammation....
Accumulation of uPA locally in the joint cavity is a typical finding in erosive RA. uPA exerts potent arthritogenic properties and th …
Cystatin C binds serum amyloid A, downregulating its cytokine-generating properties.
Bokarewa M, Abrahamson M, Levshin N, Egesten A, Grubb A, Dahlberg L, Tarkowski A. Bokarewa M, et al. Among authors: tarkowski a. J Rheumatol. 2007 Jun;34(6):1293-301. J Rheumatol. 2007. PMID: 17552057
OBJECTIVE: To assess the interaction between cystatin C (CysC) and serum amyloid A protein (SAA). METHODS: Levels of CysC and SAA and antibodies against these proteins were assessed in the paired blood and synovial fluid (SF) samples of 90 patients with rheumatoid arthriti …
OBJECTIVE: To assess the interaction between cystatin C (CysC) and serum amyloid A protein (SAA). METHODS: Levels of CysC and SAA and …
Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis.
Rehnberg M, Amu S, Tarkowski A, Bokarewa MI, Brisslert M. Rehnberg M, et al. Among authors: tarkowski a. Arthritis Res Ther. 2009;11(4):R123. doi: 10.1186/ar2789. Epub 2009 Aug 17. Arthritis Res Ther. 2009. PMID: 19686595 Free PMC article.
A significant reduction of CD27+ cells in BM and in circulation was observed long after rituximab treatment (mean 22 months), while levels of naive B cells in BM and in circulation were increased. ...CONCLUSIONS: Anti-CD20 treatment achieves a depletion of IgD+ B ce
A significant reduction of CD27+ cells in BM and in circulation was observed long after rituximab treatment (mean 22 months), while l
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