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Antiproliferative effects of SR31747A in animal cell lines are mediated by inhibition of cholesterol biosynthesis at the sterol isomerase step.
Labit-Le Bouteiller C, Jamme MF, David M, Silve S, Lanau C, Dhers C, Picard C, Rahier A, Taton M, Loison G, Caput D, Ferrara P, Lupker J. Labit-Le Bouteiller C, et al. Among authors: taton m. Eur J Biochem. 1998 Sep 1;256(2):342-9. doi: 10.1046/j.1432-1327.1998.2560342.x. Eur J Biochem. 1998. PMID: 9760173 Free article.
Potent inhibition of cholesterol biosynthesis in 3T3 fibroblasts by N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol, a new 2,3-oxidosqualene cyclase inhibitor.
Gerst N, Duriatti A, Schuber F, Taton M, Benveniste P, Rahier A. Gerst N, et al. Among authors: taton m. Biochem Pharmacol. 1988 May 15;37(10):1955-64. doi: 10.1016/0006-2952(88)90542-4. Biochem Pharmacol. 1988. PMID: 3377803
N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol, a new compound rationally designed to inhibit the 2,3-oxidosqualene cyclase (M. Taton et al., Biochem. biophys. Res. Commun. 138, 764, 1986) was studied as an inhibitor of cholesterol biosyn …
N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol, a new compound rationally designed to inhibit the 2,3-oxidosqual …
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