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A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications.
Tavendale R, Macgregor DF, Mukhopadhyay S, Palmer CN. Tavendale R, et al. J Allergy Clin Immunol. 2008 Apr;121(4):860-3. doi: 10.1016/j.jaci.2008.01.015. J Allergy Clin Immunol. 2008. PMID: 18395550
Environmental tobacco smoke and lung function in employees who never smoked: the Scottish MONICA study.
Chen R, Tunstall-Pedoe H, Tavendale R. Chen R, et al. Among authors: tavendale r. Occup Environ Med. 2001 Sep;58(9):563-8. doi: 10.1136/oem.58.9.563. Occup Environ Med. 2001. PMID: 11511742 Free PMC article.
Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.
Bisgaard H, Bønnelykke K, Sleiman PM, Brasholt M, Chawes B, Kreiner-Møller E, Stage M, Kim C, Tavendale R, Baty F, Pipper CB, Palmer CN, Hakonarsson H. Bisgaard H, et al. Among authors: tavendale r. Am J Respir Crit Care Med. 2009 Feb 1;179(3):179-85. doi: 10.1164/rccm.200809-1436OC. Epub 2008 Nov 21. Am J Respir Crit Care Med. 2009. PMID: 19029000
An obesity-associated FTO gene variant and increased energy intake in children.
Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN. Cecil JE, et al. Among authors: tavendale r. N Engl J Med. 2008 Dec 11;359(24):2558-66. doi: 10.1056/NEJMoa0803839. N Engl J Med. 2008. PMID: 19073975
Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: a Go-DARTS study.
Zhou K, Donnelly L, Burch L, Tavendale R, Doney AS, Leese G, Hattersley AT, McCarthy MI, Morris AD, Lang CC, Palmer CN, Pearson ER. Zhou K, et al. Among authors: tavendale r. Clin Pharmacol Ther. 2010 Jan;87(1):52-6. doi: 10.1038/clpt.2009.176. Epub 2009 Sep 30. Clin Pharmacol Ther. 2010. PMID: 19794412
Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol.
Basu K, Palmer CN, Tavendale R, Lipworth BJ, Mukhopadhyay S. Basu K, et al. Among authors: tavendale r. J Allergy Clin Immunol. 2009 Dec;124(6):1188-94.e3. doi: 10.1016/j.jaci.2009.07.043. J Allergy Clin Immunol. 2009. PMID: 19800676
Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults.
Mukhopadhyay S, Sypek J, Tavendale R, Gartner U, Winter J, Li W, Page K, Fleming M, Brady J, O'Toole M, Macgregor DF, Goldman S, Tam S, Abraham W, Williams C, Miller DK, Palmer CN. Mukhopadhyay S, et al. Among authors: tavendale r. J Allergy Clin Immunol. 2010 Jul;126(1):70-6.e16. doi: 10.1016/j.jaci.2010.03.027. Epub 2010 May 23. J Allergy Clin Immunol. 2010. PMID: 20546881
Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth.
Bønnelykke K, Pipper CB, Tavendale R, Palmer CN, Bisgaard H. Bønnelykke K, et al. Among authors: tavendale r. Pediatr Allergy Immunol. 2010 Sep;21(6):954-61. doi: 10.1111/j.1399-3038.2010.01073.x. Epub 2010 Jun 21. Pediatr Allergy Immunol. 2010. PMID: 20573035 Clinical Trial.
Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study.
Donnelly LA, Doney AS, Tavendale R, Lang CC, Pearson ER, Colhoun HM, McCarthy MI, Hattersley AT, Morris AD, Palmer CN. Donnelly LA, et al. Among authors: tavendale r. Clin Pharmacol Ther. 2011 Feb;89(2):210-6. doi: 10.1038/clpt.2010.255. Epub 2010 Dec 22. Clin Pharmacol Ther. 2011. PMID: 21178985 Free PMC article.
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group; Wellcome Trust Case Control Consortium 2, Zhou K, Bellenguez C, Spencer CC, Bennett AJ, Coleman RL, Tavendale R, Hawley SA, Donnelly LA, Schofield C, Groves CJ, Burch L, Carr F, Strange A, Freeman C, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Gray E, Hunt S, Jankowski J, Langford C, Markus HS, Mathew CG, Plomin R, Rautanen A, Sawcer SJ, Samani NJ, Trembath R, Viswanathan AC, Wood NW; MAGIC investigators, Harries LW, Hattersley AT, Doney AS, Colhoun H, Morris AD, Sutherland C, Hardie DG, Peltonen L, McCarthy MI, Holman RR, Palmer CN, Donnelly P, Pearson ER. GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group, et al. Among authors: tavendale r. Nat Genet. 2011 Feb;43(2):117-20. doi: 10.1038/ng.735. Epub 2010 Dec 26. Nat Genet. 2011. PMID: 21186350 Free PMC article.
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