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Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes.
Scaglione JB, Jastrzebska I, Krishnan K, Li P, Akk G, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Scaglione JB, et al. Among authors: taylor a. J Med Chem. 2008 Mar 13;51(5):1309-18. doi: 10.1021/jm701128r. Epub 2008 Feb 15. J Med Chem. 2008. PMID: 18275132
Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors.
Shu HJ, Eisenman LN, Wang C, Bandyopadhyaya AK, Krishnan K, Taylor A, Benz AM, Manion B, Evers AS, Covey DF, Zorumski CF, Mennerick S. Shu HJ, et al. Among authors: taylor a. Mol Pharmacol. 2009 Oct;76(4):754-65. doi: 10.1124/mol.109.057687. Epub 2009 Jul 13. Mol Pharmacol. 2009. PMID: 19596835 Free PMC article.
Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.
Bandyopadhyaya AK, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Bandyopadhyaya AK, et al. Among authors: taylor a. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6680-4. doi: 10.1016/j.bmcl.2010.09.008. Epub 2010 Sep 15. Bioorg Med Chem Lett. 2010. PMID: 20875742 Free PMC article.
Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity.
Stastna E, Krishnan K, Manion BD, Taylor A, Rath NP, Chen ZW, Evers AS, Zorumski CF, Mennerick S, Covey DF. Stastna E, et al. Among authors: taylor a. J Med Chem. 2011 Jun 9;54(11):3926-34. doi: 10.1021/jm2002487. Epub 2011 May 6. J Med Chem. 2011. PMID: 21504158 Free PMC article.
Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.
Qian M, Krishnan K, Kudova E, Li P, Manion BD, Taylor A, Elias G, Akk G, Evers AS, Zorumski CF, Mennerick S, Covey DF. Qian M, et al. Among authors: taylor a. J Med Chem. 2014 Jan 9;57(1):171-90. doi: 10.1021/jm401577c. Epub 2013 Dec 24. J Med Chem. 2014. PMID: 24328079 Free PMC article.
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