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The discovery of [1-(4-dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethylbutyl)-phen yl]-(3-methyl-but-2-enyl)-amine, an N-type Ca+2 channel blocker with oral activity for analgesia.
Hu LY, Ryder TR, Rafferty MF, Taylor CP, Feng MR, Kuo BS, Lotarski SM, Miljanich GP, Millerman E, Siebers KM, Szoke BG. Hu LY, et al. Among authors: taylor cp. Bioorg Med Chem. 2000 Jun;8(6):1203-12. doi: 10.1016/s0968-0896(00)00077-8. Bioorg Med Chem. 2000. PMID: 10896101
N,N-dialkyl-dipeptidylamines as novel N-type calcium channel blockers.
Hu LY, Ryder TR, Rafferty MF, Cody WL, Lotarski SM, Miljanich GP, Millerman E, Rock DM, Song Y, Stoehr SJ, Taylor CP, Weber ML, Szoke BG, Vartanian MG. Hu LY, et al. Among authors: taylor cp. Bioorg Med Chem Lett. 1999 Mar 22;9(6):907-12. doi: 10.1016/s0960-894x(99)00100-6. Bioorg Med Chem Lett. 1999. PMID: 10206559
A summary of mechanistic hypotheses of gabapentin pharmacology.
Taylor CP, Gee NS, Su TZ, Kocsis JD, Welty DF, Brown JP, Dooley DJ, Boden P, Singh L. Taylor CP, et al. Epilepsy Res. 1998 Feb;29(3):233-49. doi: 10.1016/s0920-1211(97)00084-3. Epilepsy Res. 1998. PMID: 9551785 Review.
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