Taylor DW - Search Results

1

SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation.

Steens JA, Zhu Y, Taylor DW, Bravo JPK, Prinsen SHP, Schoen CD, Keijser BJF, Ossendrijver M, Hofstra LM, Brouns SJJ, Shinkai A, van der Oost J, Staals RHJ. Steens JA, et al. Among authors: taylor dw. Nat Commun. 2021 Aug 19;12(1):5033. doi: 10.1038/s41467-021-25337-5. Nat Commun. 2021. PMID: 34413302 Free PMC article.

2

Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus.

Staals RHJ, Agari Y, Maki-Yonekura S, Zhu Y, Taylor DW, van Duijn E, Barendregt A, Vlot M, Koehorst JJ, Sakamoto K, Masuda A, Dohmae N, Schaap PJ, Doudna JA, Heck AJR, Yonekura K, van der Oost J, Shinkai A. Staals RHJ, et al. Among authors: taylor dw. Mol Cell. 2013 Oct 10;52(1):135-145. doi: 10.1016/j.molcel.2013.09.013. Mol Cell. 2013. PMID: 24119403 Free PMC article.

3

RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus.

Staals RH, Zhu Y, Taylor DW, Kornfeld JE, Sharma K, Barendregt A, Koehorst JJ, Vlot M, Neupane N, Varossieau K, Sakamoto K, Suzuki T, Dohmae N, Yokoyama S, Schaap PJ, Urlaub H, Heck AJ, Nogales E, Doudna JA, Shinkai A, van der Oost J. Staals RH, et al. Among authors: taylor dw. Mol Cell. 2014 Nov 20;56(4):518-30. doi: 10.1016/j.molcel.2014.10.005. Epub 2014 Nov 6. Mol Cell. 2014. PMID: 25457165 Free PMC article.

4

Structural biology. Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning.

Taylor DW, Zhu Y, Staals RH, Kornfeld JE, Shinkai A, van der Oost J, Nogales E, Doudna JA. Taylor DW, et al. Science. 2015 May 1;348(6234):581-5. doi: 10.1126/science.aaa4535. Epub 2015 Apr 2. Science. 2015. PMID: 25837515 Free PMC article.

5

DNA Unwinding Is the Primary Determinant of CRISPR-Cas9 Activity.

Gong S, Yu HH, Johnson KA, Taylor DW. Gong S, et al. Among authors: taylor dw. Cell Rep. 2018 Jan 9;22(2):359-371. doi: 10.1016/j.celrep.2017.12.041. Cell Rep. 2018. PMID: 29320733 Free article.

6

Kinetic characterization of Cas9 enzymes.

Liu MS, Gong S, Yu HH, Taylor DW, Johnson KA. Liu MS, et al. Among authors: taylor dw. Methods Enzymol. 2019;616:289-311. doi: 10.1016/bs.mie.2018.10.022. Epub 2019 Jan 14. Methods Enzymol. 2019. PMID: 30691648 Free PMC article.

7

Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome.

Zhou Y, Musalgaonkar S, Johnson AW, Taylor DW. Zhou Y, et al. Among authors: taylor dw. Nat Commun. 2019 Feb 27;10(1):958. doi: 10.1038/s41467-019-08880-0. Nat Commun. 2019. PMID: 30814529 Free PMC article.

8

The final cut: Cas9 editing.

Taylor DW. Taylor DW. Nat Struct Mol Biol. 2019 Aug;26(8):669-670. doi: 10.1038/s41594-019-0267-1. Nat Struct Mol Biol. 2019. PMID: 31285603 No abstract available.

9

Engineered CRISPR/Cas9 enzymes improve discrimination by slowing DNA cleavage to allow release of off-target DNA.

Liu MS, Gong S, Yu HH, Jung K, Johnson KA, Taylor DW. Liu MS, et al. Among authors: taylor dw. Nat Commun. 2020 Jul 17;11(1):3576. doi: 10.1038/s41467-020-17411-1. Nat Commun. 2020. PMID: 32681021 Free PMC article.

10

Structural basis for assembly of non-canonical small subunits into type I-C Cascade.

O'Brien RE, Santos IC, Wrapp D, Bravo JPK, Schwartz EA, Brodbelt JS, Taylor DW. O'Brien RE, et al. Among authors: taylor dw. Nat Commun. 2020 Nov 23;11(1):5931. doi: 10.1038/s41467-020-19785-8. Nat Commun. 2020. PMID: 33230133 Free PMC article.

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