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Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate.
Maini RN, Taylor PC, Szechinski J, Pavelka K, Bröll J, Balint G, Emery P, Raemen F, Petersen J, Smolen J, Thomson D, Kishimoto T; CHARISMA Study Group. Maini RN, et al. Arthritis Rheum. 2006 Sep;54(9):2817-29. doi: 10.1002/art.22033. Arthritis Rheum. 2006. PMID: 16947782 Clinical Trial.
Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease.
Maini RN, Elliott MJ, Brennan FM, Williams RO, Chu CQ, Paleolog E, Charles PJ, Taylor PC, Feldmann M. Maini RN, et al. Immunol Rev. 1995 Apr;144:195-223. doi: 10.1111/j.1600-065x.1995.tb00070.x. Immunol Rev. 1995. PMID: 7590814 Review.
Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis.
Tak PP, Taylor PC, Breedveld FC, Smeets TJ, Daha MR, Kluin PM, Meinders AE, Maini RN. Tak PP, et al. Arthritis Rheum. 1996 Jul;39(7):1077-81. doi: 10.1002/art.1780390702. Arthritis Rheum. 1996. PMID: 8670314 Clinical Trial.
Transfer of type II collagen-induced arthritis from DBA/1 to severe combined immunodeficiency mice can be prevented by blockade of Mac-1.
Taylor PC, Chu CQ, Plater-Zyberk C, Maini RN. Taylor PC, et al. Immunology. 1996 Jun;88(2):315-21. doi: 10.1111/j.1365-2567.1996.tb00021.x. Immunology. 1996. PMID: 8690467 Free PMC article.
Anti-tumour necrosis factor specific antibody (infliximab) treatment provides insights into the pathophysiology of rheumatoid arthritis.
Maini RN, Taylor PC, Paleolog E, Charles P, Ballara S, Brennan FM, Feldmann M. Maini RN, et al. Ann Rheum Dis. 1999 Nov;58 Suppl 1(Suppl 1):I56-60. doi: 10.1136/ard.58.2008.i56. Ann Rheum Dis. 1999. PMID: 10577974 Free PMC article. Review. No abstract available.
Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis.
Taylor PC, Peters AM, Paleolog E, Chapman PT, Elliott MJ, McCloskey R, Feldmann M, Maini RN. Taylor PC, et al. Arthritis Rheum. 2000 Jan;43(1):38-47. doi: 10.1002/1529-0131(200001)43:1<38::AID-ANR6>3.0.CO;2-L. Arthritis Rheum. 2000. PMID: 10643698
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