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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 2
1992 2
1994 1
1995 4
1996 3
1997 2
1998 5
1999 4
2001 2
2002 2
2003 4
2004 5
2005 7
2006 4
2007 11
2008 10
2009 15
2010 9
2011 17
2012 19
2013 22
2014 19
2015 27
2016 20
2017 30
2018 34
2019 46
2020 59
2021 71
2022 55
2023 65
2024 23

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539 results

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Page 1
Central memory CD8(+) T cells derive from stem-like Tcf7(hi) effector cells in the absence of cytotoxic differentiation.
Pais Ferreira D, Silva JG, Wyss T, Fuertes Marraco SA, Scarpellino L, Charmoy M, Maas R, Siddiqui I, Tang L, Joyce JA, Delorenzi M, Luther SA, Speiser DE, Held W. Pais Ferreira D, et al. Immunity. 2020 Nov 17;53(5):985-1000.e11. doi: 10.1016/j.immuni.2020.09.005. Epub 2020 Oct 30. Immunity. 2020. PMID: 33128876 Free article.
These effector-phase Tcf7(hi) cells quantitatively yielded Tcm cells based on lineage tracing. Mechanistically, Tcf1 counteracted the differentiation of Tcf7(hi) cells and sustained the expression of conserved adult stem-cell genes that were critical for CD8(+) T ce …
These effector-phase Tcf7(hi) cells quantitatively yielded Tcm cells based on lineage tracing. Mechanistically, Tcf1 counteracted the …
TCF7 is not essential for glucose homeostasis in mice.
Kaur KD, Wong CK, Baggio LL, Beaudry JL, Fuchs S, Panaro BL, Matthews D, Cao X, Drucker DJ. Kaur KD, et al. Mol Metab. 2021 Jun;48:101213. doi: 10.1016/j.molmet.2021.101213. Epub 2021 Mar 17. Mol Metab. 2021. PMID: 33741532 Free PMC article.
TCF7 has also been associated with glucose homeostasis control in the liver. ...Moreover, the detection of Tcf7 expression within islet mRNA is attributable to the expression of Tcf7 RNA in islet-associated murine immune cells, and not in islet beta-cells....
TCF7 has also been associated with glucose homeostasis control in the liver. ...Moreover, the detection of Tcf7 expression wit …
Single-cell profiling of tumor-infiltrating TCF1/TCF7(+) T cells reveals a T lymphocyte subset associated with tertiary lymphoid structures/organs and a superior prognosis in oral cancer.
Peng Y, Xiao L, Rong H, Ou Z, Cai T, Liu N, Li B, Zhang L, Wu F, Lan T, Lin X, Li Q, Ren S, Fan S, Li J. Peng Y, et al. Oral Oncol. 2021 Aug;119:105348. doi: 10.1016/j.oraloncology.2021.105348. Epub 2021 May 25. Oral Oncol. 2021. PMID: 34044317
RESULTS: We found a strong association between TCF1/TCF7(+) T cell subsets, TLSs and prognosis. The results suggested that TCF1/TCF7(+) T cells express high levels of TLS-related genes and low levels of immune checkpoint molecules. Finally, we found that TCF1/TCF …
RESULTS: We found a strong association between TCF1/TCF7(+) T cell subsets, TLSs and prognosis. The results suggested that TCF1/TC …
TCF7/SNAI2/miR-4306 feedback loop promotes hypertrophy of ligamentum flavum.
Duan Y, Li J, Qiu S, Ni S, Cao Y. Duan Y, et al. J Transl Med. 2022 Oct 12;20(1):468. doi: 10.1186/s12967-022-03677-0. J Transl Med. 2022. PMID: 36224570 Free PMC article.
Then effect of TCF7 on HLF progression was investigated both in vitro and in vivo. ...CONCLUSIONS: Our study demonstrated that TCF7 inhibition could suppress HLF formation by modulating TCF7/SNAI2/miR-4306 feedback loop, which might be considered as a novel p …
Then effect of TCF7 on HLF progression was investigated both in vitro and in vivo. ...CONCLUSIONS: Our study demonstrated that TCF …
Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis.
Guo Y, Guo Y, Chen C, Fan D, Wu X, Zhao L, Shao B, Sun Z, Ji Z. Guo Y, et al. Mol Cancer. 2021 Jun 25;20(1):93. doi: 10.1186/s12943-021-01372-0. Mol Cancer. 2021. PMID: 34172072 Free PMC article.
Mechanism analysis showed that circ3823 act as a competing endogenous RNA of miR-30c-5p to relieve the repressive effect of miR-30c-5p on its target TCF7 which upregulates MYC and CCND1, and finally facilitates CRC progression. ...CONCLUSIONS: Our findings suggest that cir …
Mechanism analysis showed that circ3823 act as a competing endogenous RNA of miR-30c-5p to relieve the repressive effect of miR-30c-5p on it …
Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma.
Sade-Feldman M, Yizhak K, Bjorgaard SL, Ray JP, de Boer CG, Jenkins RW, Lieb DJ, Chen JH, Frederick DT, Barzily-Rokni M, Freeman SS, Reuben A, Hoover PJ, Villani AC, Ivanova E, Portell A, Lizotte PH, Aref AR, Eliane JP, Hammond MR, Vitzthum H, Blackmon SM, Li B, Gopalakrishnan V, Reddy SM, Cooper ZA, Paweletz CP, Barbie DA, Stemmer-Rachamimov A, Flaherty KT, Wargo JA, Boland GM, Sullivan RJ, Getz G, Hacohen N. Sade-Feldman M, et al. Cell. 2018 Nov 1;175(4):998-1013.e20. doi: 10.1016/j.cell.2018.10.038. Cell. 2018. PMID: 30388456 Free PMC article.
Two distinct states of CD8(+) T cells were defined by clustering and associated with patient tumor regression or progression. A single transcription factor, TCF7, was visualized within CD8(+) T cells in fixed tumor samples and predicted positive clinical outcome in an inde …
Two distinct states of CD8(+) T cells were defined by clustering and associated with patient tumor regression or progression. A single trans …
Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade.
Pai JA, Hellmann MD, Sauter JL, Mattar M, Rizvi H, Woo HJ, Shah N, Nguyen EM, Uddin FZ, Quintanal-Villalonga A, Chan JM, Manoj P, Allaj V, Baine MK, Bhanot UK, Jain M, Linkov I, Meng F, Brown D, Chaft JE, Plodkowski AJ, Gigoux M, Won HH, Sen T, Wells DK, Donoghue MTA, de Stanchina E, Wolchok JD, Loomis B, Merghoub T, Rudin CM, Chow A, Satpathy AT. Pai JA, et al. Cancer Cell. 2023 Apr 10;41(4):776-790.e7. doi: 10.1016/j.ccell.2023.03.009. Epub 2023 Mar 30. Cancer Cell. 2023. PMID: 37001526 Free PMC article.
Tracking T cell clonotypes across tissues, combined with neoantigen specificity assays, reveals that TFH and tumor-specific exhausted CD8(+) T cells are clonally linked to TCF7(+)SELL(+) progenitors in tumor draining LNs, and progressive exhaustion trajectories of CD8(+) T …
Tracking T cell clonotypes across tissues, combined with neoantigen specificity assays, reveals that TFH and tumor-specific exhausted CD8(+) …
A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer.
Bassez A, Vos H, Van Dyck L, Floris G, Arijs I, Desmedt C, Boeckx B, Vanden Bempt M, Nevelsteen I, Lambein K, Punie K, Neven P, Garg AD, Wildiers H, Qian J, Smeets A, Lambrechts D. Bassez A, et al. Nat Med. 2021 May;27(5):820-832. doi: 10.1038/s41591-021-01323-8. Epub 2021 May 6. Nat Med. 2021. PMID: 33958794
In pre-treatment biopsies, the relative frequency of immunoregulatory dendritic cells (PD-L1(+)), specific macrophage phenotypes (CCR2(+) or MMP9(+)) and cancer cells exhibiting major histocompatibility complex class I/II expression correlated positively with T cell expansion. Co …
In pre-treatment biopsies, the relative frequency of immunoregulatory dendritic cells (PD-L1(+)), specific macrophage phenotypes (CCR2(+) or …
Wnt-TCF7-SOX9 axis promotes cholangiocarcinoma proliferation and pemigatinib resistance in a FGF7-FGFR2 autocrine pathway.
Liu Z, Liu J, Chen T, Wang Y, Shi A, Li K, Li X, Qiu B, Zheng L, Zhao L, Shu L, Lian S, Huang S, Zhang Z, Xu Y. Liu Z, et al. Oncogene. 2022 May;41(20):2885-2896. doi: 10.1038/s41388-022-02313-x. Epub 2022 Apr 15. Oncogene. 2022. PMID: 35428876
With WNT3A stimulation, SOX9 expression and transcription was elevated by TCF7. Moreover, SOX9 was substantially up-regulated in CCA tissues and was identified as a prognostic biomarker of CCA. ...In conclusion, SOX9 and FGF7 were prognostic biomarkers of CCA. WNT3A-TCF …
With WNT3A stimulation, SOX9 expression and transcription was elevated by TCF7. Moreover, SOX9 was substantially up-regulated in CCA …
Tertiary lymphoid structures improve immunotherapy and survival in melanoma.
Cabrita R, Lauss M, Sanna A, Donia M, Skaarup Larsen M, Mitra S, Johansson I, Phung B, Harbst K, Vallon-Christersson J, van Schoiack A, Lövgren K, Warren S, Jirström K, Olsson H, Pietras K, Ingvar C, Isaksson K, Schadendorf D, Schmidt H, Bastholt L, Carneiro A, Wargo JA, Svane IM, Jönsson G. Cabrita R, et al. Nature. 2020 Jan;577(7791):561-565. doi: 10.1038/s41586-019-1914-8. Epub 2020 Jan 15. Nature. 2020. PMID: 31942071
Furthermore, B-cell-rich tumours were accompanied by increased levels of TCF7(+) naive and/or memory T cells. This was corroborated by digital spatial-profiling data, in which T cells in tumours without tertiary lymphoid structures had a dysfunctional molecular phenotype. …
Furthermore, B-cell-rich tumours were accompanied by increased levels of TCF7(+) naive and/or memory T cells. This was corroborated b …
539 results