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Page 1
Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics.
Bhalani DV, Nutan B, Kumar A, Singh Chandel AK. Bhalani DV, et al. Biomedicines. 2022 Aug 23;10(9):2055. doi: 10.3390/biomedicines10092055. Biomedicines. 2022. PMID: 36140156 Free PMC article. Review.
These pharmaceuticals demonstrate less solubility and bioavailability. Enhancement of the bioavailability and solubility of drugs is a significant challenge in the area of pharmaceutical formulations. According to the Classification of Biopharma …
These pharmaceuticals demonstrate less solubility and bioavailability. Enhancement of the bioavailability and solubilit …
Engineering Cocrystals of PoorlyWater-Soluble Drugs to Enhance Dissolution in Aqueous Medium.
Sathisaran I, Dalvi SV. Sathisaran I, et al. Pharmaceutics. 2018 Jul 31;10(3):108. doi: 10.3390/pharmaceutics10030108. Pharmaceutics. 2018. PMID: 30065221 Free PMC article. Review.
Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. ...Many researchers have shown that the cocrystals significantly enhance the aqueous solubility of poorl …
Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence …
Improving Oral Bioavailability of Herbal Drugs: A Focused Review of Self-Emulsifying Drug Delivery System for Colon Cancer.
Bhardwaj K, Sharma A, Kumar R, Tyagi V, Kumar R. Bhardwaj K, et al. Curr Drug Deliv. 2024;21(3):389-402. doi: 10.2174/1567201820666230505113108. Curr Drug Deliv. 2024. PMID: 37151062 Review.
In the formulation of oral medications, low inconsistent bioavailability is a major challenge. Increasing medication bioavailability is one of the most difficult aspects of pharmacological development. Self-nano-emulsifying drug delivery systems (SNEDDS) have been a …
In the formulation of oral medications, low inconsistent bioavailability is a major challenge. Increasing medication bioavailabili …
Drug carrier systems for solubility enhancement of BCS class II drugs: a critical review.
Kumar S, Bhargava D, Thakkar A, Arora S. Kumar S, et al. Crit Rev Ther Drug Carrier Syst. 2013;30(3):217-56. doi: 10.1615/critrevtherdrugcarriersyst.2013005964. Crit Rev Ther Drug Carrier Syst. 2013. PMID: 23614647 Review.
Poor aqueous solubility impedes a drug's bioavailability and challenges its pharmaceutical development. Pharmaceutical development of drugs with poor water solubility requires the establishment of a suitable formulation layout among vario …
Poor aqueous solubility impedes a drug's bioavailability and challenges its pharmaceutical development. Pharm …
Nanoemulsion: A Novel Drug Delivery Approach for Enhancement of Bioavailability.
Pandey P, Gulati N, Makhija M, Purohit D, Dureja H. Pandey P, et al. Recent Pat Nanotechnol. 2020 Dec 24;14(4):276-293. doi: 10.2174/1872210514666200604145755. Recent Pat Nanotechnol. 2020. PMID: 32496999 Review.
OBJECTIVES: BCS class II and IV which are poorly soluble in water demonstrate various problems in conventional dosage forms. For the improvement of solubility, bioavailability and getting the best therapeutic effect of poorly soluble drugs nanoe …
OBJECTIVES: BCS class II and IV which are poorly soluble in water demonstrate various problems in conventional dosage f …
Development Considerations for Nanocrystal Drug Products.
Chen ML, John M, Lee SL, Tyner KM. Chen ML, et al. AAPS J. 2017 May;19(3):642-651. doi: 10.1208/s12248-017-0064-x. Epub 2017 Mar 9. AAPS J. 2017. PMID: 28281194 Review.
Nanocrystal technology has emerged as a valuable tool for facilitating the delivery of poorly water-soluble active pharmaceutical ingredients (APIs) and enhancing API bioavailability. To date, the US Food and Drug Administration (FDA) has received over 80 app …
Nanocrystal technology has emerged as a valuable tool for facilitating the delivery of poorly water-soluble active pharmaceutical ing …
Bioavailability Enhancement of Poorly Water-Soluble Drugs via Nanocomposites: Formulation-Processing Aspects and Challenges.
Bhakay A, Rahman M, Dave RN, Bilgili E. Bhakay A, et al. Pharmaceutics. 2018 Jul 8;10(3):86. doi: 10.3390/pharmaceutics10030086. Pharmaceutics. 2018. PMID: 29986543 Free PMC article. Review.
Drug nanoparticles embedded in a dispersant matrix as a secondary phase, i.e., drug-laden nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and bioavailability of poorly water-soluble drugs. Drug nanoparticles are prepared …
Drug nanoparticles embedded in a dispersant matrix as a secondary phase, i.e., drug-laden nanocomposites, offer a versatile delivery platfor …
Crystal Engineering for Enhanced Solubility and Bioavailability of Poorly Soluble Drugs.
Varshosaz J, Ghassami E, Ahmadipour S. Varshosaz J, et al. Curr Pharm Des. 2018;24(21):2473-2496. doi: 10.2174/1381612824666180712104447. Curr Pharm Des. 2018. PMID: 29998799 Review.
BACKGROUND: Crystal engineering is dealing with the creation of new structures and new properties in drug molecules through inter-molecular interactions. Researchers of pharmaceutical sciences have used this knowledge to alter the structure of crystalline medications in or …
BACKGROUND: Crystal engineering is dealing with the creation of new structures and new properties in drug molecules through inter-molecular …
Nanosuspension: A Formulation Technology for Tackling the Poor Aqueous Solubility and Bioavailability of Poorly Soluble Drugs.
Elsebay MT, Eissa NG, Balata GF, Kamal MA, Elnahas HM. Elsebay MT, et al. Curr Pharm Des. 2023;29(29):2297-2312. doi: 10.2174/1381612829666230911105922. Curr Pharm Des. 2023. PMID: 37694786 Review.
Biopharmaceutics Classification System (BCS) class II drugs face particular hurdles due to their limited solubility in the aqueous media of the gastrointestinal tract. ...To address these challenges, nanosuspension techniques offer a promising s …
Biopharmaceutics Classification System (BCS) class II drugs face particular hurdles due to their limited solubil …
Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems.
Gupta B, Mishra V, Gharat S, Momin M, Omri A. Gupta B, et al. Pharmaceuticals (Basel). 2021 Nov 22;14(11):1201. doi: 10.3390/ph14111201. Pharmaceuticals (Basel). 2021. PMID: 34832983 Free PMC article. Review.
The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Biopharmaceutical Classification System (BCS) class II drugs with adequate permeability and limited or no aqueous sol …
The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Bioph …
26 results