Tedeschi P - Search Results

1

Enhanced degradation of dihydrofolate reductase through inhibition of NAD kinase by nicotinamide analogs.

Hsieh YC, Tedeschi P, Adebisi Lawal R, Banerjee D, Scotto K, Kerrigan JE, Lee KC, Johnson-Farley N, Bertino JR, Abali EE. Hsieh YC, et al. Among authors: tedeschi p. Mol Pharmacol. 2013 Feb;83(2):339-53. doi: 10.1124/mol.112.080218. Epub 2012 Nov 29. Mol Pharmacol. 2013. PMID: 23197646 Free PMC article.

2

In cancer, all roads lead to NADPH.

Rather GM, Pramono AA, Szekely Z, Bertino JR, Tedeschi PM. Rather GM, et al. Pharmacol Ther. 2021 Oct;226:107864. doi: 10.1016/j.pharmthera.2021.107864. Epub 2021 Apr 22. Pharmacol Ther. 2021. PMID: 33894275 Review.

3

Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy.

Tedeschi PM, Lin H, Gounder M, Kerrigan JE, Abali EE, Scotto K, Bertino JR. Tedeschi PM, et al. Mol Pharmacol. 2015 Oct;88(4):720-7. doi: 10.1124/mol.114.096727. Epub 2015 Jul 28. Mol Pharmacol. 2015. PMID: 26219913 Free PMC article.

4

NAD+ Kinase as a Therapeutic Target in Cancer.

Tedeschi PM, Bansal N, Kerrigan JE, Abali EE, Scotto KW, Bertino JR. Tedeschi PM, et al. Clin Cancer Res. 2016 Nov 1;22(21):5189-5195. doi: 10.1158/1078-0432.CCR-16-1129. Epub 2016 Aug 31. Clin Cancer Res. 2016. PMID: 27582489 Review.

5

Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors.

Vazquez A, Tedeschi PM, Bertino JR. Vazquez A, et al. Cancer Res. 2013 Jan 15;73(2):478-82. doi: 10.1158/0008-5472.CAN-12-3709. Epub 2012 Nov 7. Cancer Res. 2013. PMID: 23135910 Free PMC article.

6

Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts.

Tedeschi PM, Kathari YK, Farooqi IN, Bertino JR. Tedeschi PM, et al. Cancer Chemother Pharmacol. 2014 Nov;74(5):1029-32. doi: 10.1007/s00280-014-2580-z. Epub 2014 Sep 9. Cancer Chemother Pharmacol. 2014. PMID: 25205429 Free PMC article.

7

Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination.

Tedeschi PM, Kathari YK, Johnson-Farley N, Bertino JR. Tedeschi PM, et al. Cancer Chemother Pharmacol. 2015 Jun;75(6):1247-52. doi: 10.1007/s00280-015-2747-2. Epub 2015 Apr 28. Cancer Chemother Pharmacol. 2015. PMID: 25917288 Free PMC article.

8

Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development.

Tedeschi PM, Vazquez A, Kerrigan JE, Bertino JR. Tedeschi PM, et al. Mol Cancer Res. 2015 Oct;13(10):1361-6. doi: 10.1158/1541-7786.MCR-15-0117. Epub 2015 Jun 22. Mol Cancer Res. 2015. PMID: 26101208 Free PMC article.

9

MTHFD2--a new twist?

Tedeschi PM, Scotto KW, Kerrigan J, Bertino JR. Tedeschi PM, et al. Oncotarget. 2016 Feb 16;7(7):7368-9. doi: 10.18632/oncotarget.7147. Oncotarget. 2016. PMID: 26848977 Free PMC article. No abstract available.

10

Functional annotation of rare gene aberration drivers of pancreatic cancer.

Tsang YH, Dogruluk T, Tedeschi PM, Wardwell-Ozgo J, Lu H, Espitia M, Nair N, Minelli R, Chong Z, Chen F, Chang QE, Dennison JB, Dogruluk A, Li M, Ying H, Bertino JR, Gingras MC, Ittmann M, Kerrigan J, Chen K, Creighton CJ, Eterovic K, Mills GB, Scott KL. Tsang YH, et al. Nat Commun. 2016 Jan 25;7:10500. doi: 10.1038/ncomms10500. Nat Commun. 2016. PMID: 26806015 Free PMC article.

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