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Myeloproliferative neoplasms: A decade of discoveries and treatment advances.
Tefferi A. Tefferi A. Am J Hematol. 2016 Jan;91(1):50-8. doi: 10.1002/ajh.24221. Am J Hematol. 2016. PMID: 26492355 Review.
In 2005, William Vainchenker and others described a Janus kinase 2 mutation (JAK2V617F) in MPN and this was followed by a series of additional descriptions of mutations that directly or indirectly activate JAK-STAT: JAK2 exon 12, myeloproliferative leukemia virus on …
In 2005, William Vainchenker and others described a Janus kinase 2 mutation (JAK2V617F) in MPN and this was followed by a seri …
Agnogenic myeloid metaplasia.
Tefferi A, Silverstein MN. Tefferi A, et al. Cancer Invest. 1997;15(2):177-9. doi: 10.3109/07357909709115771. Cancer Invest. 1997. PMID: 9095214 Review. No abstract available.
Cytogenetic findings and their clinical relevance in myelofibrosis with myeloid metaplasia.
Tefferi A, Mesa RA, Schroeder G, Hanson CA, Li CY, Dewald GW. Tefferi A, et al. Br J Haematol. 2001 Jun;113(3):763-71. doi: 10.1046/j.1365-2141.2001.02796.x. Br J Haematol. 2001. PMID: 11380468
The prognostic significance of bone marrow cytogenetic lesions in myelofibrosis with myeloid metaplasia (MMM) was investigated in a retrospective series of 165 patients. ...In a multivariate analysis that incorporated other clinical and laboratory variables, the pre …
The prognostic significance of bone marrow cytogenetic lesions in myelofibrosis with myeloid metaplasia (MMM) was investigated in a r …
Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro.
Mow BM, Chandra J, Svingen PA, Hallgren CG, Weisberg E, Kottke TJ, Narayanan VL, Litzow MR, Griffin JD, Sausville EA, Tefferi A, Kaufmann SH. Mow BM, et al. Among authors: tefferi a. Blood. 2002 Jan 15;99(2):664-71. doi: 10.1182/blood.v99.2.664. Blood. 2002. PMID: 11781252
Collectively, these results identify adaphostin as a mechanistically distinct CML-selective agent that retains activity in STI571-resistant cell lines....
Collectively, these results identify adaphostin as a mechanistically distinct CML-selective agent that retains activity in STI571-res …
Current management of polycythemia vera.
Tefferi A. Tefferi A. Leuk Lymphoma. 2002 Jan;43(1):1-7. doi: 10.1080/10428190210200. Leuk Lymphoma. 2002. PMID: 11908711 Review.
Over a century has elapsed since the first description of polycythemia vera (PV), and current treatment recommendations are primarily based on the results of clinical trials that were performed in the late 1960s and early 1970s. ...Transformation of PV into either myelofib …
Over a century has elapsed since the first description of polycythemia vera (PV), and current treatment recommendations are primarily …
Thalidomide treatment in myelofibrosis with myeloid metaplasia.
Elliott MA, Mesa RA, Li CY, Hook CC, Ansell SM, Levitt RM, Geyer SM, Tefferi A. Elliott MA, et al. Among authors: tefferi a. Br J Haematol. 2002 May;117(2):288-96. doi: 10.1046/j.1365-2141.2002.03443.x. Br J Haematol. 2002. PMID: 11972510 Clinical Trial.
Furthermore, a prognostically detrimental increase in bone marrow angiogenesis has recently been demonstrated. These observations suggest a potential therapeutic role for agents that are inhibitory to angiogenesis as well as cytokines that are pathogenetically impli …
Furthermore, a prognostically detrimental increase in bone marrow angiogenesis has recently been demonstrated. These observations sug …
The prognostic significance of trisomy 8 in patients with acute myeloid leukemia.
Elliott MA, Letendre L, Hanson CA, Tefferi A, Dewald GW. Elliott MA, et al. Among authors: tefferi a. Leuk Lymphoma. 2002 Mar;43(3):583-6. doi: 10.1080/10428190290012074. Leuk Lymphoma. 2002. PMID: 12002762
Complete remission was achieved in 85% with isolated +8, 100% with +8 and chromosomal abnormalities predictive of a favorable outcome, and 47% of patients with +8 and other, mostly complex chromosomal abnormalities. ...
Complete remission was achieved in 85% with isolated +8, 100% with +8 and chromosomal abnormalities predictive of a favorable outcome …
Diagnostic and prognostic value of bone marrow angiogenesis and megakaryocyte c-Mpl expression in essential thrombocythemia.
Mesa RA, Hanson CA, Li CY, Yoon SY, Rajkumar SV, Schroeder G, Tefferi A. Mesa RA, et al. Among authors: tefferi a. Blood. 2002 Jun 1;99(11):4131-7. doi: 10.1182/blood.v99.11.4131. Blood. 2002. PMID: 12010817
Decreased megakaryocyte c-Mpl staining was observed in a heterogeneous pattern in ET compared with healthy controls (P <.0001) and RT (P <.0001). ...
Decreased megakaryocyte c-Mpl staining was observed in a heterogeneous pattern in ET compared with healthy controls (P <.0001) and …
Cytogenetic and molecular genetic aspects of essential thrombocythemia.
Steensma DP, Tefferi A. Steensma DP, et al. Among authors: tefferi a. Acta Haematol. 2002;108(2):55-65. doi: 10.1159/000064754. Acta Haematol. 2002. PMID: 12187022 Review.
Essential thrombocythemia (ET) is a chronic myeloid disorder that is characterized by thrombocytosis, thrombohemorrhagic and vasomotor symptoms, a long median survival, and a low risk of transformation to leukemia. ...Although ET has been assumed to be a
Essential thrombocythemia (ET) is a chronic myeloid disorder that is characterized by thrombocytosis, thrombohemorrhagic and vasomoto …
Polycythemia vera--a case report and discussion on pathogenic mechanisms of increased thrombosis.
Gumina RJ, Foley DA, Tefferi A, Rooke TW, Shields RC. Gumina RJ, et al. Among authors: tefferi a. Angiology. 2002 Sep-Oct;53(5):587-91. doi: 10.1177/000331970205300514. Angiology. 2002. PMID: 12365868
Polycythemia vera is a myeloproliferative disorder characterized by increased red cell mass and frequently complicated by venous and arterial thrombosis. ...Presented in this report are a case of a 77-year-old man diagnosed with polycythemia vera and a
Polycythemia vera is a myeloproliferative disorder characterized by increased red cell mass and frequently complicated by venous and …
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