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Telomerase activation by genomic rearrangements in high-risk neuroblastoma.
Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, Krämer A, Roncaioli JL, Sand F, Heuckmann JM, Ikram F, Schmidt R, Ackermann S, Engesser A, Kahlert Y, Vogel W, Altmüller J, Nürnberg P, Thierry-Mieg J, Thierry-Mieg D, Mariappan A, Heynck S, Mariotti E, Henrich KO, Gloeckner C, Bosco G, Leuschner I, Schweiger MR, Savelyeva L, Watkins SC, Shao C, Bell E, Höfer T, Achter V, Lang U, Theissen J, Volland R, Saadati M, Eggert A, de Wilde B, Berthold F, Peng Z, Zhao C, Shi L, Ortmann M, Büttner R, Perner S, Hero B, Schramm A, Schulte JH, Herrmann C, O'Sullivan RJ, Westermann F, Thomas RK, Fischer M. Peifer M, et al. Nature. 2015 Oct 29;526(7575):700-4. doi: 10.1038/nature14980. Epub 2015 Oct 14. Nature. 2015. PMID: 26466568 Free PMC article.
Here we have performed whole-genome sequencing of 56 neuroblastomas (high-risk, n = 39; low-risk, n = 17) and discovered recurrent genomic rearrangements affecting a chromosomal region at 5p15.33 proximal of the telomerase r …
Here we have performed whole-genome sequencing of 56 neuroblastomas (high-risk, n = 39; low-risk, n = 17) …
Telomere Trimming and DNA Damage as Signatures of High Risk Neuroblastoma.
Yu EY, Cheung IY, Feng Y, Rabie MO, Roboz GJ, Guzman ML, Cheung NV, Lue NF. Yu EY, et al. Neoplasia. 2019 Jul;21(7):689-701. doi: 10.1016/j.neo.2019.04.002. Epub 2019 May 23. Neoplasia. 2019. PMID: 31128432 Free PMC article.
Telomeres play important roles in genome stability and cell proliferation. High risk neuroblastoma (HRNB), an aggressive childhood cancer, is especially reliant on telomere maintenance. ...Moreover, unlike other cancers, neuroblastoma consistent …
Telomeres play important roles in genome stability and cell proliferation. High risk neuroblastoma (HRNB), an ag …
TERT promotor region rearrangements analyzed in high-risk neuroblastomas by FISH method and whole genome sequencing.
Kawashima M, Ueda Y, Kurihara S, Hiyama E. Kawashima M, et al. Int J Clin Oncol. 2020 Sep 7. doi: 10.1007/s10147-020-01773-z. Online ahead of print. Int J Clin Oncol. 2020. PMID: 32894394
BACKGROUND: Unfavorable neuroblastomas (NBLs) achieve telomere stabilization via telomerase activation through MYCN amplification, TERT promoter region (TERT-PR) rearrangements, or alternative telomere lengthening of telomeres. ...CONCLUSIONS: FISH is …
BACKGROUND: Unfavorable neuroblastomas (NBLs) achieve telomere stabilization via telomerase activation through MYCN amp …
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