Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2015 1
2019 2
2020 1
2021 1
2022 1
2023 0
Text availability
Article attribute
Article type
Publication date

Search Results

6 results
Results by year

Citations

1 article found by citation matching

Search results

Filters applied: . Clear all
Page 1
Telomerase activation by genomic rearrangements in high-risk neuroblastoma.
Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, Krämer A, Roncaioli JL, Sand F, Heuckmann JM, Ikram F, Schmidt R, Ackermann S, Engesser A, Kahlert Y, Vogel W, Altmüller J, Nürnberg P, Thierry-Mieg J, Thierry-Mieg D, Mariappan A, Heynck S, Mariotti E, Henrich KO, Gloeckner C, Bosco G, Leuschner I, Schweiger MR, Savelyeva L, Watkins SC, Shao C, Bell E, Höfer T, Achter V, Lang U, Theissen J, Volland R, Saadati M, Eggert A, de Wilde B, Berthold F, Peng Z, Zhao C, Shi L, Ortmann M, Büttner R, Perner S, Hero B, Schramm A, Schulte JH, Herrmann C, O'Sullivan RJ, Westermann F, Thomas RK, Fischer M. Peifer M, et al. Nature. 2015 Oct 29;526(7575):700-4. doi: 10.1038/nature14980. Epub 2015 Oct 14. Nature. 2015. PMID: 26466568 Free PMC article.
Here we have performed whole-genome sequencing of 56 neuroblastomas (high-risk, n = 39; low-risk, n = 17) and discovered recurrent genomic rearrangements affecting a chromosomal region at 5p15.33 proximal of the telomerase r …
Here we have performed whole-genome sequencing of 56 neuroblastomas (high-risk, n = 39; low-risk, n = 17) …
TERT promotor region rearrangements analyzed in high-risk neuroblastomas by FISH method and whole genome sequencing.
Kawashima M, Ueda Y, Kurihara S, Hiyama E. Kawashima M, et al. Int J Clin Oncol. 2020 Dec;25(12):2166-2174. doi: 10.1007/s10147-020-01773-z. Epub 2020 Sep 7. Int J Clin Oncol. 2020. PMID: 32894394
BACKGROUND: Unfavorable neuroblastomas (NBLs) achieve telomere stabilization via telomerase activation through MYCN amplification, TERT promoter region (TERT-PR) rearrangements, or alternative telomere lengthening of telomeres. ...CONCLUSIONS: FISH is …
BACKGROUND: Unfavorable neuroblastomas (NBLs) achieve telomere stabilization via telomerase activation through MYCN amp …
How Do Telomere Abnormalities Regulate the Biology of Neuroblastoma?
Akter J, Kamijo T. Akter J, et al. Biomolecules. 2021 Jul 28;11(8):1112. doi: 10.3390/biom11081112. Biomolecules. 2021. PMID: 34439779 Free PMC article. Review.
Telomere maintenance plays important roles in genome stability and cell proliferation. Tumor cells acquire replicative immortality by activating a telomere-maintenance mechanism (TMM), either telomerase, a reverse transcriptase, or the alternative lengthening …
Telomere maintenance plays important roles in genome stability and cell proliferation. Tumor cells acquire replicative immortality by …
Reliable assessment of telomere maintenance mechanisms in neuroblastoma.
Meeser A, Bartenhagen C, Werr L, Hellmann AM, Kahlert Y, Hemstedt N, Nürnberg P, Altmüller J, Ackermann S, Hero B, Simon T, Peifer M, Fischer M, Rosswog C. Meeser A, et al. Cell Biosci. 2022 Sep 24;12(1):160. doi: 10.1186/s13578-022-00896-2. Cell Biosci. 2022. PMID: 36153564 Free PMC article.
BACKGROUND: Telomere maintenance mechanisms (TMM) are a hallmark of high-risk neuroblastoma, and are conferred by activation of telomerase or alternative lengthening of telomeres (ALT). ...CONCLUSIONS: We here propose a workflow to reliably dete …
BACKGROUND: Telomere maintenance mechanisms (TMM) are a hallmark of high-risk neuroblastoma, and are conferred by ac …
Telomerase Is a Prognostic Marker of Poor Outcome and a Therapeutic Target in Neuroblastoma.
Roderwieser A, Sand F, Walter E, Fischer J, Gecht J, Bartenhagen C, Ackermann S, Otte F, Welte A, Kahlert Y, Lieberz D, Hertwig F, Reinhardt HC, Simon T, Peifer M, Ortmann M, Büttner R, Hero B, O'Sullivan RJ, Berthold F, Fischer M. Roderwieser A, et al. JCO Precis Oncol. 2019 Dec;3:1-20. doi: 10.1200/PO.19.00072. JCO Precis Oncol. 2019. PMID: 35100718
PURPOSE: Telomere maintenance is a hallmark of high-risk neuroblastoma; however, the contribution of telomerase and alternative lengthening of telomeres (ALT) to clinical phenotypes has remained unclear. ...Similarly, tumor growth was strongly impaired …
PURPOSE: Telomere maintenance is a hallmark of high-risk neuroblastoma; however, the contribution of telomerase …
Telomere Trimming and DNA Damage as Signatures of High Risk Neuroblastoma.
Yu EY, Cheung IY, Feng Y, Rabie MO, Roboz GJ, Guzman ML, Cheung NV, Lue NF. Yu EY, et al. Neoplasia. 2019 Jul;21(7):689-701. doi: 10.1016/j.neo.2019.04.002. Epub 2019 May 23. Neoplasia. 2019. PMID: 31128432 Free PMC article.
Telomeres play important roles in genome stability and cell proliferation. High risk neuroblastoma (HRNB), an aggressive childhood cancer, is especially reliant on telomere maintenance. ...Our analysis pointed to substantial and variable degrees of tel …
Telomeres play important roles in genome stability and cell proliferation. High risk neuroblastoma (HRNB), an ag …