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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1991 2
1993 3
1994 1
1995 4
1996 3
1997 9
1998 10
1999 2
2000 5
2001 10
2002 20
2003 9
2004 23
2005 25
2006 22
2007 26
2008 20
2009 15
2010 20
2011 17
2012 13
2013 26
2014 29
2015 25
2016 27
2017 25
2018 28
2019 26
2020 30
2021 35
2022 26
2023 23

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502 results

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Page 1
Germline mutations predisposing to melanoma.
Toussi A, Mans N, Welborn J, Kiuru M. Toussi A, et al. J Cutan Pathol. 2020 Jul;47(7):606-616. doi: 10.1111/cup.13689. Epub 2020 May 11. J Cutan Pathol. 2020. PMID: 32249949 Free PMC article. Review.
CDKN2A mutations are responsible for the majority of hereditary melanoma, but many other susceptibility genes have been discovered in recent years, including CDK4, TERT, ACD, TERF2IP, POT1, MITF, MC1R, and BAP1. Additionally, melanoma risk is increased in mixed cancer syndrome …
CDKN2A mutations are responsible for the majority of hereditary melanoma, but many other susceptibility genes have been discovered in recent …
Mechanisms and treatment of late-life depression.
Alexopoulos GS. Alexopoulos GS. Transl Psychiatry. 2019 Aug 5;9(1):188. doi: 10.1038/s41398-019-0514-6. Transl Psychiatry. 2019. PMID: 31383842 Free PMC article. Review.
Depression predisposes to medical illnesses and advances biological aging indicated by shorter telomere length, accelerated brain aging and advanced epigenetic aging. ...Dopamine D(2/3) agonists are effective in depression of Parkinson's disease and their efficacy n …
Depression predisposes to medical illnesses and advances biological aging indicated by shorter telomere length, accelerated brain agi …
Telomere-mediated lung disease.
Alder JK, Armanios M. Alder JK, et al. Physiol Rev. 2022 Oct 1;102(4):1703-1720. doi: 10.1152/physrev.00046.2021. Epub 2022 May 9. Physiol Rev. 2022. PMID: 35532056 Free PMC article. Review.
The short telomere defect is pervasive in a subset of IPF patients, and human IPF is the phenotype most intimately tied to germline defects in telomere maintenance. ...Beyond explaining genetic susceptibility, short telomere length uncovers clinically relevan …
The short telomere defect is pervasive in a subset of IPF patients, and human IPF is the phenotype most intimately tied to germline d …
Hutchinson-Gilford Progeria Syndrome: A Premature Aging Disease.
Ahmed MS, Ikram S, Bibi N, Mir A. Ahmed MS, et al. Mol Neurobiol. 2018 May;55(5):4417-4427. doi: 10.1007/s12035-017-0610-7. Epub 2017 Jun 28. Mol Neurobiol. 2018. PMID: 28660486 Review.
Progeria is sporadic, very rare, autosomal dominant, deadly childhood disorder. It is one of the progeroid syndromes also known as Hutchinson-Gilford progeria syndrome (HGPS). ...The most important genetic linkage between progeria and aging is shortening of telom …
Progeria is sporadic, very rare, autosomal dominant, deadly childhood disorder. It is one of the progeroid syndromes also known as Hu …
Li-Fraumeni syndrome heterogeneity.
Gargallo P, Yáñez Y, Segura V, Juan A, Torres B, Balaguer J, Oltra S, Castel V, Cañete A. Gargallo P, et al. Clin Transl Oncol. 2020 Jul;22(7):978-988. doi: 10.1007/s12094-019-02236-2. Epub 2019 Nov 5. Clin Transl Oncol. 2020. PMID: 31691207 Review.
Clinical variability is commonly seen in Li-Fraumeni syndrome. Phenotypic heterogeneity is present among different families affected by the same pathogenic variant in TP53 gene and among members of the same family. ...
Clinical variability is commonly seen in Li-Fraumeni syndrome. Phenotypic heterogeneity is present among different families affected …
Genetics of human telomere biology disorders.
Revy P, Kannengiesser C, Bertuch AA. Revy P, et al. Nat Rev Genet. 2023 Feb;24(2):86-108. doi: 10.1038/s41576-022-00527-z. Epub 2022 Sep 23. Nat Rev Genet. 2023. PMID: 36151328 Review.
Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that prevent the activation of DNA damage response and repair pathways. ...In humans, Mendelian defects in several of these factors can result in abnormally short or dysfunctional telom …
Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that prevent the activation of DNA damage respon …
Pathogenesis of aplastic anemia.
Wang L, Liu H. Wang L, et al. Hematology. 2019 Dec;24(1):559-566. doi: 10.1080/16078454.2019.1642548. Hematology. 2019. PMID: 31315542 Review.
The symptoms are similar to myelofibrosis, myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) making diagnosis of AA complicated. ...
The symptoms are similar to myelofibrosis, myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) making diagnosis of AA co …
Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations.
Gonzalo S, Kreienkamp R, Askjaer P. Gonzalo S, et al. Ageing Res Rev. 2017 Jan;33:18-29. doi: 10.1016/j.arr.2016.06.007. Epub 2016 Jun 29. Ageing Res Rev. 2017. PMID: 27374873 Free PMC article. Review.
This review focuses on one of the most severe laminopathies, Hutchinson-Gilford Progeria Syndrome (HGPS), which is caused by aberrant splicing of the LMNA gene and expression of a mutant product called progerin. ...In particular, progerin accumulation elicits nuclear morph …
This review focuses on one of the most severe laminopathies, Hutchinson-Gilford Progeria Syndrome (HGPS), which is caused by aberrant …
Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection.
Blackburn EH, Epel ES, Lin J. Blackburn EH, et al. Science. 2015 Dec 4;350(6265):1193-8. doi: 10.1126/science.aab3389. Science. 2015. PMID: 26785477 Review.
Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes. ...Greater overall telomere attrition predicts mortality and aging-related diseases in inherited telomere syndrome patients, and also in general human cohorts. ...
Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes. ...Greater overall telomere attrition pre …
Association between genetically determined telomere length and health-related outcomes: A systematic review and meta-analysis of Mendelian randomization studies.
Chen B, Yan Y, Wang H, Xu J. Chen B, et al. Aging Cell. 2023 Jul;22(7):e13874. doi: 10.1111/acel.13874. Epub 2023 May 26. Aging Cell. 2023. PMID: 37232505 Free PMC article. Review.
Emerging evidence has shown that leukocyte telomere length (LTL) is associated with various health-related outcomes, while the causality of these associations remains unclear. ...Further research is required to elucidate the underlying mechanisms and to bring insight into …
Emerging evidence has shown that leukocyte telomere length (LTL) is associated with various health-related outcomes, while the causal …
502 results