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Year Number of Results
1985 1
1991 1
1992 4
1993 2
1994 1
1995 1
1996 3
1997 2
1998 4
1999 3
2000 4
2001 3
2002 2
2003 7
2004 9
2005 8
2006 8
2007 11
2008 7
2009 16
2010 11
2011 13
2012 16
2013 16
2014 24
2015 26
2016 26
2017 30
2018 28
2019 39
2020 30
2021 43
2022 33
2023 47
2024 70
2025 85
2026 21

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597 results

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Page 1
Vitamin D(3) and marine omega-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial.
Zhu H, Manson JE, Cook NR, Bekele BB, Chen L, Kane KJ, Huang Y, Li W, Christen W, Lee IM, Dong Y. Zhu H, et al. Am J Clin Nutr. 2025 Jul;122(1):39-47. doi: 10.1016/j.ajcnut.2025.05.003. Epub 2025 May 21. Am J Clin Nutr. 2025. PMID: 40409468 Clinical Trial.
LTL was determined by the Absolute Human Telomere Length Quantification quantitative Polymerase Chain Reaction (PCR) method at baseline, Year 2, and Year 4. ...CONCLUSION: 4-years of supplementation with 2000 IU/day vitamin D(3) reduced telomere attrition by 140 bp, …
LTL was determined by the Absolute Human Telomere Length Quantification quantitative Polymerase Chain Reaction (PCR) method at baseli …
Pan-cancer analysis of whole genomes.
ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Nature. 2020 Feb;578(7793):82-93. doi: 10.1038/s41586-020-1969-6. Epub 2020 Feb 5. Nature. 2020. PMID: 32025007 Free PMC article.
Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simulta …
Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evo …
Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction.
Zhu Y, Liu X, Ding X, Wang F, Geng X. Zhu Y, et al. Biogerontology. 2019 Feb;20(1):1-16. doi: 10.1007/s10522-018-9769-1. Epub 2018 Sep 18. Biogerontology. 2019. PMID: 30229407 Review.
Due to the mechanism of replication, telomeres shorten as cells proliferate, which consequently contributes to cellular senescence and mitochondrial dysfunction. ...In this review, we summarized the main mechanisms of cellular senescence, mitochondrial malfunction and agin …
Due to the mechanism of replication, telomeres shorten as cells proliferate, which consequently contributes to cellular senescence an …
Ovarian aging: mechanisms and intervention strategies.
Zhu Z, Xu W, Liu L. Zhu Z, et al. Med Rev (2021). 2022 Nov 22;2(6):590-610. doi: 10.1515/mr-2022-0031. eCollection 2022 Dec. Med Rev (2021). 2022. PMID: 37724254 Free PMC article. Review.
Poor oocyte quality with increasing age could result from chromosomal cohesion deterioration and misaligned chromosomes, telomere shortening, DNA damage and associated genetic mutations, oxidative stress, mitochondrial dysfunction and epigenetic alteration. ...
Poor oocyte quality with increasing age could result from chromosomal cohesion deterioration and misaligned chromosomes, telomere sho …
A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence.
Cheng Y, Wang S, Zhang H, Lee JS, Ni C, Guo J, Chen E, Wang S, Acharya A, Chang TC, Buszczak M, Zhu H, Mendell JT. Cheng Y, et al. Cell. 2024 Aug 22;187(17):4770-4789.e23. doi: 10.1016/j.cell.2024.06.019. Epub 2024 Jul 8. Cell. 2024. PMID: 38981482 Free PMC article.
Cellular senescence is an irreversible state of cell-cycle arrest induced by various stresses, including aberrant oncogene activation, telomere shortening, and DNA damage. Through a genome-wide screen, we discovered a conserved small nucleolar RNA (snoRNA), SNORA13, that i …
Cellular senescence is an irreversible state of cell-cycle arrest induced by various stresses, including aberrant oncogene activation, te …
The complete sequence of a human Y chromosome.
Rhie A, Nurk S, Cechova M, Hoyt SJ, Taylor DJ, Altemose N, Hook PW, Koren S, Rautiainen M, Alexandrov IA, Allen J, Asri M, Bzikadze AV, Chen NC, Chin CS, Diekhans M, Flicek P, Formenti G, Fungtammasan A, Garcia Giron C, Garrison E, Gershman A, Gerton JL, Grady PGS, Guarracino A, Haggerty L, Halabian R, Hansen NF, Harris R, Hartley GA, Harvey WT, Haukness M, Heinz J, Hourlier T, Hubley RM, Hunt SE, Hwang S, Jain M, Kesharwani RK, Lewis AP, Li H, Logsdon GA, Lucas JK, Makalowski W, Markovic C, Martin FJ, Mc Cartney AM, McCoy RC, McDaniel J, McNulty BM, Medvedev P, Mikheenko A, Munson KM, Murphy TD, Olsen HE, Olson ND, Paulin LF, Porubsky D, Potapova T, Ryabov F, Salzberg SL, Sauria MEG, Sedlazeck FJ, Shafin K, Shepelev VA, Shumate A, Storer JM, Surapaneni L, Taravella Oill AM, Thibaud-Nissen F, Timp W, Tomaszkiewicz M, Vollger MR, Walenz BP, Watwood AC, Weissensteiner MH, Wenger AM, Wilson MA, Zarate S, Zhu Y, Zook JM, Eichler EE, O'Neill RJ, Schatz MC, Miga KH, Makova KD, Phillippy AM. Rhie A, et al. Nature. 2023 Sep;621(7978):344-354. doi: 10.1038/s41586-023-06457-y. Epub 2023 Aug 23. Nature. 2023. PMID: 37612512 Free PMC article.
As a result, more than half of the Y chromosome is missing from the GRCh38 reference sequence and it remains the last human chromosome to be finished(4,5). Here, the Telomere-to-Telomere (T2T) consortium presents the complete 62,460,029-base-pair sequence of a human …
As a result, more than half of the Y chromosome is missing from the GRCh38 reference sequence and it remains the last human chromosome to be …
Complete sequencing of ape genomes.
Yoo D, Rhie A, Hebbar P, Antonacci F, Logsdon GA, Solar SJ, Antipov D, Pickett BD, Safonova Y, Montinaro F, Luo Y, Malukiewicz J, Storer JM, Lin J, Sequeira AN, Mangan RJ, Hickey G, Monfort Anez G, Balachandran P, Bankevich A, Beck CR, Biddanda A, Borchers M, Bouffard GG, Brannan E, Brooks SY, Carbone L, Carrel L, Chan AP, Crawford J, Diekhans M, Engelbrecht E, Feschotte C, Formenti G, Garcia GH, de Gennaro L, Gilbert D, Green RE, Guarracino A, Gupta I, Haddad D, Han J, Harris RS, Hartley GA, Harvey WT, Hiller M, Hoekzema K, Houck ML, Jeong H, Kamali K, Kellis M, Kille B, Lee C, Lee Y, Lees W, Lewis AP, Li Q, Loftus M, Loh YHE, Loucks H, Ma J, Mao Y, Martinez JFI, Masterson P, McCoy RC, McGrath B, McKinney S, Meyer BS, Miga KH, Mohanty SK, Munson KM, Pal K, Pennell M, Pevzner PA, Porubsky D, Potapova T, Ringeling FR, Rocha JL, Ryder OA, Sacco S, Saha S, Sasaki T, Schatz MC, Schork NJ, Shanks C, Smeds L, Son DR, Steiner C, Sweeten AP, Tassia MG, Thibaud-Nissen F, Torres-González E, Trivedi M, Wei W, Wertz J, Yang M, Zhang P, Zhang S, Zhang Y, Zhang Z, Zhao SA, Zhu Y, Jarvis ED, Gerton JL, Rivas-González I, Paten B, Szpiech ZA, Huber CD, Lenz TL, Konkel MK, Yi SV, Canzar S, Watson C… See abstract for full author list ➔ Yoo D, et al. Nature. 2025 May;641(8062):401-418. doi: 10.1038/s41586-025-08816-3. Epub 2025 Apr 9. Nature. 2025. PMID: 40205052 Free PMC article.
We achieve chromosome-level contiguity with substantial sequence accuracy (<1 error in 2.7 megabases) and completely sequence 215 gapless chromosomes telomere-to-telomere. We resolve challenging regions, such as the major histocompatibility complex and immunoglob …
We achieve chromosome-level contiguity with substantial sequence accuracy (<1 error in 2.7 megabases) and completely sequence 215 gapless …
Sex-Specific Association Between Childhood Adversity and Accelerated Biological Aging.
Yu J, Pu F, Yang G, Hao M, Zhang H, Zhang J, Cao X, Zhu L, Wan Y, Wang X, Liu Z. Yu J, et al. Adv Sci (Weinh). 2024 Jul;11(26):e2309346. doi: 10.1002/advs.202309346. Epub 2024 May 5. Adv Sci (Weinh). 2024. PMID: 38704685 Free PMC article.
Childhood adversity is assessed through the online mental health questionnaire (2016), including physical neglect, physical abuse, emotional neglect, emotional abuse, sexual abuse, and a cumulative score. Biological aging is indicated by telomere length (TL) measured from …
Childhood adversity is assessed through the online mental health questionnaire (2016), including physical neglect, physical abuse, emotional …
Complex genetic variation in nearly complete human genomes.
Logsdon GA, Ebert P, Audano PA, Loftus M, Porubsky D, Ebler J, Yilmaz F, Hallast P, Prodanov T, Yoo D, Paisie CA, Harvey WT, Zhao X, Martino GV, Henglin M, Munson KM, Rabbani K, Chin CS, Gu B, Ashraf H, Scholz S, Austine-Orimoloye O, Balachandran P, Bonder MJ, Cheng H, Chong Z, Crabtree J, Gerstein M, Guethlein LA, Hasenfeld P, Hickey G, Hoekzema K, Hunt SE, Jensen M, Jiang Y, Koren S, Kwon Y, Li C, Li H, Li J, Norman PJ, Oshima KK, Paten B, Phillippy AM, Pollock NR, Rausch T, Rautiainen M, Song Y, Söylev A, Sulovari A, Surapaneni L, Tsapalou V, Zhou W, Zhou Y, Zhu Q, Zody MC, Mills RE, Devine SE, Shi X, Talkowski ME, Chaisson MJP, Dilthey AT, Konkel MK, Korbel JO, Lee C, Beck CR, Eichler EE, Marschall T. Logsdon GA, et al. Nature. 2025 Aug;644(8076):430-441. doi: 10.1038/s41586-025-09140-6. Epub 2025 Jul 23. Nature. 2025. PMID: 40702183 Free PMC article.
Here we sequence 65 diverse human genomes and build 130 haplotype-resolved assemblies (median continuity of 130 Mb), closing 92% of all previous assembly gaps(1,2) and reaching telomere-to-telomere status for 39% of the chromosomes. We highlight complete sequence co …
Here we sequence 65 diverse human genomes and build 130 haplotype-resolved assemblies (median continuity of 130 Mb), closing 92% of all prev …
Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery.
Shen CY, Jiang JG, Yang L, Wang DW, Zhu W. Shen CY, et al. Br J Pharmacol. 2017 Jun;174(11):1395-1425. doi: 10.1111/bph.13631. Epub 2016 Oct 29. Br J Pharmacol. 2017. PMID: 27659301 Free PMC article. Review.
The TCMs with anti-ageing function are classified according to their action pathways, including the telomere and telomerase, the sirtuins, the mammalian target of rapamycin, AMP-activated kinase and insulin/insulin-like growth factor-1 signalling pathway, free radicals sca …
The TCMs with anti-ageing function are classified according to their action pathways, including the telomere and telomerase, the sirt …
597 results